Factors associated with newborn care knowledge and practices in the upper Himalayas
Globally, neonatal deaths remain a major public health challenge and account for the majority of deaths occurring among children under five years of age. Despite Nepal's significant achievements in meeting the maternal and child health targets of the Millennium Development Goals, an estimated 2...
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description | Globally, neonatal deaths remain a major public health challenge and account for the majority of deaths occurring among children under five years of age. Despite Nepal's significant achievements in meeting the maternal and child health targets of the Millennium Development Goals, an estimated 23,000 Nepalese children under five years die every year, with three out of five babies dying within the first 28 days of life. This study therefore aimed to examine the level of knowledge and practices of newborn care among Nepalese mothers in the upper Himalayas and the factors associated with these.
A community based cross-sectional study was conducted among 302 randomly selected mothers with children under two years of age in Tripurasundari Municipality of Dolpa district, an upper Himalayan region of Nepal. Mothers were interviewed using semi-structured questionnaires. Mean score for knowledge and Bloom's criteria for practice were considered to categorize newborn care knowledge and practices. Multivariate logistic regression was used to identify factors associated with the newborn care knowledge and practices.
In this study, 147 (48.7%) of the mothers were found to have inadequate knowledge of newborn care, while 102 (33.8%) mothers had reported unsatisfactory newborn care practices. Mothers with at least secondary level of formal education were more likely to possess adequate newborn care knowledge compared to mothers who never attended school (AOR 4.93 at 95% CI 1.82-13.33). Mothers whose first pregnancy occurred between the ages of 20-24 years (AOR 3.89 at 95% CI 1.81-8.37) were also more likely to possess adequate newborn care knowledge, compared to mothers with a younger age at first pregnancy. Furthermore, mothers who had completed at least four ANC visits (AOR 2.89 at 95% CI 1.04-7.96), mothers who had completed three PNC visits (AOR 2.79 at 95% CI 1.16-6.72) and mothers who reported that their nearest health facility was less than one hour (30-59 minutes) walking distance (AOR 3.66 at 95% CI 1.43-9.33) had higher odds of having adequate newborn care knowledge. Similarly, mothers whose household monthly income was more than $100 (AOR 4.17 at 95% CI 1.75-9.69), mothers who had completed three PNC visits (AOR 3.27 at 95% CI 1.16-9.20) and mothers with adequate newborn care knowledge (AOR 15.35 at 95% CI 5.82-40.47) were found to be more likely to practice a satisfactory level of newborn care practices in adjusted analysis.
The study revealed high prevalence |
doi_str_mv | 10.1371/journal.pone.0222582 |
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A community based cross-sectional study was conducted among 302 randomly selected mothers with children under two years of age in Tripurasundari Municipality of Dolpa district, an upper Himalayan region of Nepal. Mothers were interviewed using semi-structured questionnaires. Mean score for knowledge and Bloom's criteria for practice were considered to categorize newborn care knowledge and practices. Multivariate logistic regression was used to identify factors associated with the newborn care knowledge and practices.
In this study, 147 (48.7%) of the mothers were found to have inadequate knowledge of newborn care, while 102 (33.8%) mothers had reported unsatisfactory newborn care practices. Mothers with at least secondary level of formal education were more likely to possess adequate newborn care knowledge compared to mothers who never attended school (AOR 4.93 at 95% CI 1.82-13.33). Mothers whose first pregnancy occurred between the ages of 20-24 years (AOR 3.89 at 95% CI 1.81-8.37) were also more likely to possess adequate newborn care knowledge, compared to mothers with a younger age at first pregnancy. Furthermore, mothers who had completed at least four ANC visits (AOR 2.89 at 95% CI 1.04-7.96), mothers who had completed three PNC visits (AOR 2.79 at 95% CI 1.16-6.72) and mothers who reported that their nearest health facility was less than one hour (30-59 minutes) walking distance (AOR 3.66 at 95% CI 1.43-9.33) had higher odds of having adequate newborn care knowledge. Similarly, mothers whose household monthly income was more than $100 (AOR 4.17 at 95% CI 1.75-9.69), mothers who had completed three PNC visits (AOR 3.27 at 95% CI 1.16-9.20) and mothers with adequate newborn care knowledge (AOR 15.35 at 95% CI 5.82-40.47) were found to be more likely to practice a satisfactory level of newborn care practices in adjusted analysis.
The study revealed high prevalence of inadequate newborn care and knowledge amongst mothers in upper Himalayan dwellings. Approximately one third of all interviewed mothers practiced suboptimal newborn care. The results indicate an urgent need to increase awareness of neonatal services available to mothers and to prioritize investments by local governments in neonatal health services, in order to improve accessibility and quality of care for mothers and newborns.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0222582</identifier><identifier>PMID: 31525242</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject><![CDATA[Age ; Babies ; Beliefs, opinions and attitudes ; Biology and Life Sciences ; Child health ; Childbirth & labor ; Children ; Childrens health ; Cross-Sectional Studies ; Demography ; Dwellings ; Education ; Evidence-based medicine ; Fatalities ; Female ; Forecasts and trends ; Health care facilities ; Health care reform ; Health Facilities - statistics & numerical data ; Health Knowledge, Attitudes, Practice ; Health risk assessment ; Health services ; Humans ; Infant care ; Infant mortality ; Infant, Newborn ; Infants ; Knowledge ; Local government ; Maternal & child health ; Medical care quality ; Medicine and Health Sciences ; Mortality ; Mothers ; Neonates ; Nepal ; Newborn babies ; Newborn infants ; People and Places ; Postnatal Care - statistics & numerical data ; Postpartum period ; Pregnancy ; Prenatal Care - statistics & numerical data ; Public health ; Public opinion ; Regression analysis ; Risk factors ; Rural Population - statistics & numerical data ; Social Sciences ; Socioeconomic Factors ; Studies ; Sustainable development ; Tetanus ; Young Adult]]></subject><ispartof>PloS one, 2019-09, Vol.14 (9), p.e0222582-e0222582</ispartof><rights>COPYRIGHT 2019 Public Library of Science</rights><rights>2019 Singh et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2019 Singh et al 2019 Singh et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-abe95cab88fe22c307b066ffc7fddda7bd716c21959f57312071605081b0e213</citedby><cites>FETCH-LOGICAL-c692t-abe95cab88fe22c307b066ffc7fddda7bd716c21959f57312071605081b0e213</cites><orcidid>0000-0001-5481-4550 ; 0000-0003-1450-9476</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6746396/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6746396/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79342,79343</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31525242$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Singh, Devendra Raj</creatorcontrib><creatorcontrib>Harvey, Chloe M</creatorcontrib><creatorcontrib>Bohara, Pushpalata</creatorcontrib><creatorcontrib>Nath, Dhirendra</creatorcontrib><creatorcontrib>Singh, Sunita</creatorcontrib><creatorcontrib>Szabo, Sylvia</creatorcontrib><creatorcontrib>Karki, Kshitij</creatorcontrib><title>Factors associated with newborn care knowledge and practices in the upper Himalayas</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Globally, neonatal deaths remain a major public health challenge and account for the majority of deaths occurring among children under five years of age. Despite Nepal's significant achievements in meeting the maternal and child health targets of the Millennium Development Goals, an estimated 23,000 Nepalese children under five years die every year, with three out of five babies dying within the first 28 days of life. This study therefore aimed to examine the level of knowledge and practices of newborn care among Nepalese mothers in the upper Himalayas and the factors associated with these.
A community based cross-sectional study was conducted among 302 randomly selected mothers with children under two years of age in Tripurasundari Municipality of Dolpa district, an upper Himalayan region of Nepal. Mothers were interviewed using semi-structured questionnaires. Mean score for knowledge and Bloom's criteria for practice were considered to categorize newborn care knowledge and practices. Multivariate logistic regression was used to identify factors associated with the newborn care knowledge and practices.
In this study, 147 (48.7%) of the mothers were found to have inadequate knowledge of newborn care, while 102 (33.8%) mothers had reported unsatisfactory newborn care practices. Mothers with at least secondary level of formal education were more likely to possess adequate newborn care knowledge compared to mothers who never attended school (AOR 4.93 at 95% CI 1.82-13.33). Mothers whose first pregnancy occurred between the ages of 20-24 years (AOR 3.89 at 95% CI 1.81-8.37) were also more likely to possess adequate newborn care knowledge, compared to mothers with a younger age at first pregnancy. Furthermore, mothers who had completed at least four ANC visits (AOR 2.89 at 95% CI 1.04-7.96), mothers who had completed three PNC visits (AOR 2.79 at 95% CI 1.16-6.72) and mothers who reported that their nearest health facility was less than one hour (30-59 minutes) walking distance (AOR 3.66 at 95% CI 1.43-9.33) had higher odds of having adequate newborn care knowledge. Similarly, mothers whose household monthly income was more than $100 (AOR 4.17 at 95% CI 1.75-9.69), mothers who had completed three PNC visits (AOR 3.27 at 95% CI 1.16-9.20) and mothers with adequate newborn care knowledge (AOR 15.35 at 95% CI 5.82-40.47) were found to be more likely to practice a satisfactory level of newborn care practices in adjusted analysis.
The study revealed high prevalence of inadequate newborn care and knowledge amongst mothers in upper Himalayan dwellings. Approximately one third of all interviewed mothers practiced suboptimal newborn care. The results indicate an urgent need to increase awareness of neonatal services available to mothers and to prioritize investments by local governments in neonatal health services, in order to improve accessibility and quality of care for mothers and newborns.</description><subject>Age</subject><subject>Babies</subject><subject>Beliefs, opinions and attitudes</subject><subject>Biology and Life Sciences</subject><subject>Child health</subject><subject>Childbirth & labor</subject><subject>Children</subject><subject>Childrens health</subject><subject>Cross-Sectional Studies</subject><subject>Demography</subject><subject>Dwellings</subject><subject>Education</subject><subject>Evidence-based medicine</subject><subject>Fatalities</subject><subject>Female</subject><subject>Forecasts and trends</subject><subject>Health care facilities</subject><subject>Health care reform</subject><subject>Health Facilities - statistics & numerical data</subject><subject>Health Knowledge, Attitudes, Practice</subject><subject>Health risk assessment</subject><subject>Health services</subject><subject>Humans</subject><subject>Infant care</subject><subject>Infant mortality</subject><subject>Infant, Newborn</subject><subject>Infants</subject><subject>Knowledge</subject><subject>Local government</subject><subject>Maternal & child health</subject><subject>Medical care quality</subject><subject>Medicine and Health Sciences</subject><subject>Mortality</subject><subject>Mothers</subject><subject>Neonates</subject><subject>Nepal</subject><subject>Newborn babies</subject><subject>Newborn infants</subject><subject>People and Places</subject><subject>Postnatal Care - statistics & numerical data</subject><subject>Postpartum period</subject><subject>Pregnancy</subject><subject>Prenatal Care - statistics & numerical data</subject><subject>Public health</subject><subject>Public opinion</subject><subject>Regression analysis</subject><subject>Risk factors</subject><subject>Rural Population - statistics & numerical data</subject><subject>Social Sciences</subject><subject>Socioeconomic Factors</subject><subject>Studies</subject><subject>Sustainable development</subject><subject>Tetanus</subject><subject>Young Adult</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNkl1r1EAUhoMotlb_gWhAEL3YdT6SSeZGKMXahULBFm-Hk8nJ7tTsTDqTuPbfO7ublo30QnKRZPK87_nImyRvKZlTXtAvt27wFtp55yzOCWMsL9mz5JhKzmaCEf784PkoeRXCLSE5L4V4mRxxmrOcZew4uT4H3TsfUgjBaQM91unG9KvU4qZy3qYaPKa_rNu0WC8xBVunnY8aozGkxqb9CtOh69CnF2YNLdxDeJ28aKAN-Ga8nyQ3599uzi5ml1ffF2enlzMtJOtnUKHMNVRl2SBjmpOiIkI0jS6auq6hqOqCCs2ozGWTF5wyEt9JTkpaEWSUnyTv97Zd64Ia1xEUY5LyPBOSRGKxJ2oHt6rzsUF_rxwYtTtwfqnAx0laVBWvgRRElo2mmZYAFUUkkjU6Y5kWWfT6OlYbqjXWGm3voZ2YTr9Ys1JL91uJIhNcimjwaTTw7m7A0Ku1CRrbFiy6Ydc3iwUpzSP64R_06elGaglxAGMbF-vqrak6zaUsWEZ3fc-foOJV49romJ3GxPOJ4PNEEJke__RLGEJQi-sf_89e_ZyyHw_YFULbr4Jrh944G6Zgtge1dyF4bB6XTInaRv9hG2obfTVGP8reHf6gR9FD1vlfA6P-RA</recordid><startdate>20190916</startdate><enddate>20190916</enddate><creator>Singh, Devendra Raj</creator><creator>Harvey, Chloe M</creator><creator>Bohara, Pushpalata</creator><creator>Nath, Dhirendra</creator><creator>Singh, Sunita</creator><creator>Szabo, Sylvia</creator><creator>Karki, Kshitij</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0001-5481-4550</orcidid><orcidid>https://orcid.org/0000-0003-1450-9476</orcidid></search><sort><creationdate>20190916</creationdate><title>Factors associated with newborn care knowledge and practices in the upper Himalayas</title><author>Singh, Devendra Raj ; Harvey, Chloe M ; Bohara, Pushpalata ; Nath, Dhirendra ; Singh, Sunita ; Szabo, Sylvia ; Karki, Kshitij</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-abe95cab88fe22c307b066ffc7fddda7bd716c21959f57312071605081b0e213</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Age</topic><topic>Babies</topic><topic>Beliefs, opinions and attitudes</topic><topic>Biology and Life Sciences</topic><topic>Child health</topic><topic>Childbirth & labor</topic><topic>Children</topic><topic>Childrens health</topic><topic>Cross-Sectional Studies</topic><topic>Demography</topic><topic>Dwellings</topic><topic>Education</topic><topic>Evidence-based medicine</topic><topic>Fatalities</topic><topic>Female</topic><topic>Forecasts and trends</topic><topic>Health care facilities</topic><topic>Health care reform</topic><topic>Health Facilities - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Singh, Devendra Raj</au><au>Harvey, Chloe M</au><au>Bohara, Pushpalata</au><au>Nath, Dhirendra</au><au>Singh, Sunita</au><au>Szabo, Sylvia</au><au>Karki, Kshitij</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Factors associated with newborn care knowledge and practices in the upper Himalayas</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2019-09-16</date><risdate>2019</risdate><volume>14</volume><issue>9</issue><spage>e0222582</spage><epage>e0222582</epage><pages>e0222582-e0222582</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Globally, neonatal deaths remain a major public health challenge and account for the majority of deaths occurring among children under five years of age. Despite Nepal's significant achievements in meeting the maternal and child health targets of the Millennium Development Goals, an estimated 23,000 Nepalese children under five years die every year, with three out of five babies dying within the first 28 days of life. This study therefore aimed to examine the level of knowledge and practices of newborn care among Nepalese mothers in the upper Himalayas and the factors associated with these.
A community based cross-sectional study was conducted among 302 randomly selected mothers with children under two years of age in Tripurasundari Municipality of Dolpa district, an upper Himalayan region of Nepal. Mothers were interviewed using semi-structured questionnaires. Mean score for knowledge and Bloom's criteria for practice were considered to categorize newborn care knowledge and practices. Multivariate logistic regression was used to identify factors associated with the newborn care knowledge and practices.
In this study, 147 (48.7%) of the mothers were found to have inadequate knowledge of newborn care, while 102 (33.8%) mothers had reported unsatisfactory newborn care practices. Mothers with at least secondary level of formal education were more likely to possess adequate newborn care knowledge compared to mothers who never attended school (AOR 4.93 at 95% CI 1.82-13.33). Mothers whose first pregnancy occurred between the ages of 20-24 years (AOR 3.89 at 95% CI 1.81-8.37) were also more likely to possess adequate newborn care knowledge, compared to mothers with a younger age at first pregnancy. Furthermore, mothers who had completed at least four ANC visits (AOR 2.89 at 95% CI 1.04-7.96), mothers who had completed three PNC visits (AOR 2.79 at 95% CI 1.16-6.72) and mothers who reported that their nearest health facility was less than one hour (30-59 minutes) walking distance (AOR 3.66 at 95% CI 1.43-9.33) had higher odds of having adequate newborn care knowledge. Similarly, mothers whose household monthly income was more than $100 (AOR 4.17 at 95% CI 1.75-9.69), mothers who had completed three PNC visits (AOR 3.27 at 95% CI 1.16-9.20) and mothers with adequate newborn care knowledge (AOR 15.35 at 95% CI 5.82-40.47) were found to be more likely to practice a satisfactory level of newborn care practices in adjusted analysis.
The study revealed high prevalence of inadequate newborn care and knowledge amongst mothers in upper Himalayan dwellings. Approximately one third of all interviewed mothers practiced suboptimal newborn care. The results indicate an urgent need to increase awareness of neonatal services available to mothers and to prioritize investments by local governments in neonatal health services, in order to improve accessibility and quality of care for mothers and newborns.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>31525242</pmid><doi>10.1371/journal.pone.0222582</doi><tpages>e0222582</tpages><orcidid>https://orcid.org/0000-0001-5481-4550</orcidid><orcidid>https://orcid.org/0000-0003-1450-9476</orcidid><oa>free_for_read</oa></addata></record> |
fulltext | fulltext |
identifier | ISSN: 1932-6203 |
ispartof | PloS one, 2019-09, Vol.14 (9), p.e0222582-e0222582 |
issn | 1932-6203 1932-6203 |
language | eng |
recordid | cdi_plos_journals_2291354690 |
source | PLoS; MEDLINE; EZB Free E-Journals; DOAJ Directory of Open Access Journals; PubMed Central; Free Full-Text Journals in Chemistry |
subjects | Age Babies Beliefs, opinions and attitudes Biology and Life Sciences Child health Childbirth & labor Children Childrens health Cross-Sectional Studies Demography Dwellings Education Evidence-based medicine Fatalities Female Forecasts and trends Health care facilities Health care reform Health Facilities - statistics & numerical data Health Knowledge, Attitudes, Practice Health risk assessment Health services Humans Infant care Infant mortality Infant, Newborn Infants Knowledge Local government Maternal & child health Medical care quality Medicine and Health Sciences Mortality Mothers Neonates Nepal Newborn babies Newborn infants People and Places Postnatal Care - statistics & numerical data Postpartum period Pregnancy Prenatal Care - statistics & numerical data Public health Public opinion Regression analysis Risk factors Rural Population - statistics & numerical data Social Sciences Socioeconomic Factors Studies Sustainable development Tetanus Young Adult |
title | Factors associated with newborn care knowledge and practices in the upper Himalayas |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-04T18%3A24%3A43IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Factors%20associated%20with%20newborn%20care%20knowledge%20and%20practices%20in%20the%20upper%20Himalayas&rft.jtitle=PloS%20one&rft.au=Singh,%20Devendra%20Raj&rft.date=2019-09-16&rft.volume=14&rft.issue=9&rft.spage=e0222582&rft.epage=e0222582&rft.pages=e0222582-e0222582&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0222582&rft_dat=%3Cgale_plos_%3EA599724164%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2291354690&rft_id=info:pmid/31525242&rft_galeid=A599724164&rft_doaj_id=oai_doaj_org_article_b3da07098fc14c9aab1ee092fc424c64&rfr_iscdi=true |