Malaria vaccine candidates displayed on novel virus-like particles are immunogenic and induce transmission-blocking activity

The development of effective malaria vaccines remains a global health priority. Currently, the most advanced vaccine, known as RTS,S, has only shown modest efficacy in clinical trials. Thus, the development of more efficacious vaccines by improving the formulation of RTS,S for increased efficacy or...

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Veröffentlicht in:	PloS one 2019-09, Vol.14 (9), p.e0221733-e0221733
Hauptverfasser:	Chan, Jo-Anne, Wetzel, David, Reiling, Linda, Miura, Kazutoyo, Drew, Damien R, Gilson, Paul R, Anderson, David A, Richards, Jack S, Long, Carole A, Suckow, Manfred, Jenzelewski, Volker, Tsuboi, Takafumi, Boyle, Michelle J, Piontek, Michael, Beeson, James G
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animals Anopheles - parasitology Antibodies Antibody Affinity Antigen presentation Antigens Aquatic birds Biology and Life Sciences Biotechnology Clinical trials Cyclic GMP Disease transmission Drug resistance Effectiveness Erythrocytes Gametocytes Global health HEK293 Cells Hepatitis Hepatitis B Hepatitis B virus Hepatitis B virus - genetics Humans Immunity Immunogenicity Immunoglobulins Immunology Infectious diseases Laboratories Life sciences Malaria Malaria vaccines Malaria Vaccines - genetics Malaria Vaccines - immunology Medicine and Health Sciences Mosquito Vectors - parasitology Mosquitoes Parasites Pichia - genetics Pichia - metabolism Plasmodium falciparum Plasmodium falciparum - genetics Plasmodium falciparum - immunology Plasmodium falciparum - pathogenicity Prevention Proteins Protozoan Proteins - genetics Protozoan Proteins - immunology Rabbits Recombinant Proteins - genetics Recombinant Proteins - immunology Research and Analysis Methods Risk factors Treatment outcome Vaccine development Vaccine efficacy Vaccines Vaccines, Virus-Like Particle - genetics Vaccines, Virus-Like Particle - immunology Vector-borne diseases Viral Proteins - genetics Viral Proteins - metabolism Virus-like particles Viruses World health
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