A systems biology approach towards the identification of candidate therapeutic genes and potential biomarkers for Parkinson's disease

Parkinson's disease (PD) is an irreversible and incurable multigenic neurodegenerative disorder. It involves progressive loss of mid brain dopaminergic neurons in the substantia nigra pars compacta (SN). We compared brain gene expression profiles with those from the peripheral blood cells of a...

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Veröffentlicht in:	PloS one 2019-09, Vol.14 (9), p.e0220995-e0220995
Hauptverfasser:	Sakharkar, Meena Kishore, Kashmir Singh, Sarinder Kaur, Rajamanickam, Karthic, Mohamed Essa, Musthafa, Yang, Jian, Chidambaram, Saravana Babu
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Alleles Binding sites Biochemistry Biological activity Biological markers Biology and Life Sciences Biomarkers Biopsy Blood Blood cells Brain Brain - drug effects Brain - metabolism Brain - physiopathology Brain research Care and treatment Computational Biology - methods Criminal investigation Datasets Diagnosis Dopamine Dopamine receptors Drug Discovery Gene expression Gene Expression Profiling Genes Genetic Association Studies - methods Genetic Predisposition to Disease Handwriting Humans Identification Insects Medicine and Health Sciences Molecular Sequence Annotation Molecular Targeted Therapy Movement disorders Neurodegeneration Neurodegenerative diseases Neurological diseases Neurons Nutrition Parkinson disease Parkinson Disease - etiology Parkinson's disease Patients Peripheral blood Pharmacy R&D Research & development Substantia nigra Systems Biology - methods Target detection
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