The potential of VKORC1 polymorphisms in Mustelidae for evolving anticoagulant resistance through selection along the food chain

In response to strong selection, new mutations can arise quickly and sweep through populations, particularly, if survival and reproduction depend on certain allele copies for adaptation to rapidly changing environments, like resistance against deadly diseases or strong toxins. Since the 1950s, resis...

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Veröffentlicht in:	PloS one 2019-08, Vol.14 (8), p.e0221706
Hauptverfasser:	Stöck, Matthias, Reisch, Florian, Elmeros, Morten, Gabriel, Doreen, Kloas, Werner, Kreuz, Eva, Lassen, Pia, Esther, Alexandra
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptation Amino acids Amino Acids - genetics Animals Anticoagulants Anticoagulants - pharmacology Aquaculture Binding sites Biology and Life Sciences Changing environments Denmark Deoxyribonucleic acid DNA DNA sequencing Ecology and Environmental Sciences Environmental changes Exons - genetics Exposure Fisheries Fluorescence Food Chain Food chains Food selection Freshwater ecology Gene sequencing Genes Genetic aspects Genetic diversity Genetic polymorphisms Genetic research Genotypes Geography High performance liquid chromatography Insecticide resistance Introns - genetics Liquid chromatography Martes martes Mass spectrometry Mass spectroscopy Mustelidae Mustelidae - genetics Mutation Nucleotides Physical sciences Poisons Polymorphism, Genetic Population genetics Populations Predators Prey Primers Proteins Reductase Reductases Research and Analysis Methods Rodenticides Rodents Soil sciences Spectroscopy Statistical models Systematic review Toxins Vertebrates Vitamin K Epoxide Reductases - genetics Vitamins
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