Renal clearance of heparin-binding protein and elimination during renal replacement therapy: Studies in ICU patients and healthy volunteers

Heparin-binding protein (HBP) is released by neutrophils upon activation, and elevated plasma levels are seen in inflammatory states like sepsis, shock, cardiac arrest, and burns. However, little is known about the elimination of HBP. We wanted to study renal clearance of HBP in healthy individuals...

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Veröffentlicht in:	PloS one 2019-08, Vol.14 (8), p.e0221813-e0221813
Hauptverfasser:	Samuelsson, Line, Tydén, Jonas, Herwald, Heiko, Hultin, Magnus, Walldén, Jakob, Steinvall, Ingrid, Sjöberg, Folke, Johansson, Joakim
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Anestesi och intensivvård Anesthesiology Anesthesiology and Intensive Care Anticoagulants Antimicrobial Cationic Peptides - blood Antimicrobial Cationic Peptides - metabolism Biology and Life Sciences Biomarkers Blood Proteins - metabolism Burn patients Burn treatment Burns Burns - blood CAP37 protein Cardiac arrest Cell activation Circuits Clinical Medicine Cystatin C Earth Sciences Ecology and Environmental Sciences Effluents Fibroblast growth factor receptors Flow velocity Granulocytes Hand surgery Healthy Volunteers Heparin Hospital patients Hospitals Humans Infection Inflammation Intensive care Intensive Care Units Kidney - metabolism Kidneys Klinisk medicin Leukocytes (neutrophilic) Levels Male Measurement methods Medical and Health Sciences Medical research Medicin och hälsovetenskap Medicine Medicine and Health Sciences Middle Aged Neutrophils Permeability Plasma levels Plastic surgery Protein binding Proteins Renal function Renal Replacement Therapy Sepsis Shock Therapy Urinary tract diseases Urinary tract infections Urine Urogenital system
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