When drug treatments bias genetic studies: Mediation and interaction

Increasingly, genetic analyses are conducted using information from subjects with established disease, who often receive concomitant treatment. We determined when treatment may bias genetic associations with a quantitative trait. Graph theory and simulated data were used to explore the impact of dru...

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Veröffentlicht in:	PloS one 2019-08, Vol.14 (8), p.e0221209-e0221209
Hauptverfasser:	Schmidt, Amand F, Heerspink, Hiddo J L, Denig, Petra, Finan, Chris, Groenwold, Rolf H H
Format:	Artikel
Sprache:	eng
Schlagworte:	Accounting Bias Biology and Life Sciences Blood pressure Cardiovascular disease Computer Simulation Confidence intervals Consortia Diabetes Drug interactions Drug Prescriptions Drug therapy Engineering and Technology Estimates Genes Genetic analysis Genetic aspects Genetic Diseases, Inborn - drug therapy Genetic Diseases, Inborn - epidemiology Genetic Diseases, Inborn - genetics Genetic diversity Genetic effects Genetic research Genetic variance Genetics Genome-Wide Association Study Genomes Genotype & phenotype Graph theory Heart Humans Longitude Mediation Medical treatment Medicine and Health Sciences Negotiating Pharmacogenomic Variants - genetics Pharmacy Phenotype Phenotypes Physiological aspects Quantitative trait loci Quantitative Trait Loci - genetics Regression analysis Rejection rate Research and Analysis Methods Root-mean-square errors Studies Trajectory analysis Type 2 diabetes
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