17-β estradiol exerts anti-inflammatory effects through activation of Nrf2 in mouse embryonic fibroblasts

Several reports indicate crosstalk between the transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) and estrogen, which has a protective effect in colorectal cancer (CRC). The aim of this study was to investigate the role of Nrf2 signaling in the anti-inflammatory effect of estrog...

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Veröffentlicht in:	PloS one 2019-08, Vol.14 (8), p.e0221650-e0221650
Hauptverfasser:	Song, Chin-Hee, Kim, Nayoung, Kim, Do-Hee, Lee, Ha-Na, Surh, Young-Joon
Format:	Artikel
Sprache:	eng
Schlagworte:	17β-Estradiol Animals Anti-Inflammatory Agents - pharmacology Antioxidants Biology and Life Sciences Colorectal cancer Colorectal carcinoma Crosstalk Cytokines Embryo fibroblasts Embryo, Mammalian - cytology Embryos Enzymes Estradiol - pharmacology Estrogen receptors Estrogens Female Fibroblasts Fibroblasts - cytology Fibroblasts - drug effects Fibroblasts - metabolism Genes Growth rate Inflammation Inflammatory bowel disease Inflammatory diseases Internal medicine Male Medicine Medicine and Health Sciences Mice, Inbred C57BL Mice, Knockout Models, Biological NF-E2-Related Factor 2 - metabolism NF-kappa B - metabolism NF-κB protein Nitric oxide Nitric Oxide Synthase Type II - metabolism Nitric-oxide synthase Nuclear transport Oxidative stress Pharmacy Phenols Proteins Receptors Receptors, Estrogen - metabolism Regulatory sequences Research and Analysis Methods Sex hormones Stem cells Transcription factors Translocation Tumor Necrosis Factor-alpha - metabolism Tumor necrosis factor-TNF Tumor necrosis factor-α
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