Dosage form suitability in vulnerable populations: A focus on paracetamol acceptability from infants to centenarians
Medicine acceptability is a multi-faceted concept driven by both product and user characteristics. Although a key factor for treatment effectiveness, especially in vulnerable populations, knowledge of those medicine features that best promote individual user acceptability remains fragmented. Focusin...
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| creator | Ruiz, Fabrice Vallet, Thibault Dufaÿ Wojcicki, Amélie Belissa, Émilie Fontan, Jean-Eudes de Pontual, Loïc Nathanson, Sylvie Chevallier, Alain Laribe-Caget, Sandra Boudy, Vincent |
| description | Medicine acceptability is a multi-faceted concept driven by both product and user characteristics. Although a key factor for treatment effectiveness, especially in vulnerable populations, knowledge of those medicine features that best promote individual user acceptability remains fragmented. Focusing on paracetamol, this study has explored the appropriateness of pharmaceutical products in different dosage forms to achieve adequate patient acceptability from infants to centenarians.
This observational, multicentre, prospective study was carried out in 10 hospitals, 8 nursing homes and over 150 community dispensaries. Observers reported several behaviours/events evaluating acceptability for 1016 different pharmaceutical product uses in paediatrics ( |
| doi_str_mv | 10.1371/journal.pone.0221261 |
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This observational, multicentre, prospective study was carried out in 10 hospitals, 8 nursing homes and over 150 community dispensaries. Observers reported several behaviours/events evaluating acceptability for 1016 different pharmaceutical product uses in paediatrics (<18y.) and 1288 in the elderly (≥65y.). Using mapping and clustering, a multivariate approach offered an intelligible reference framework for each population, providing comprehensive scores: positively or negatively accepted.
Among all the evaluations supporting the acceptability reference frameworks, there were 502 reports on paracetamol products intake. Herein we focused on the 5 products with ≥30 evaluations. Although oral suspension and powder for oral solution were positively-accepted in the paediatric group, the powder had a higher rate of negative patient reaction (p<0.001). Of those that received this formulation, 72% were ≤8y., and therefore suitable to receive the better accepted oral suspension. In the elderly, patients with swallowing disorders were preferentially treated with such powders (p<0.001), which were less often fully taken than orally disintegrating tablets (p<0.001). Even in those patients ≥90y., capsule formulations appeared to be the best accepted product in patients without swallowing alterations, and thus could be a suitable alternative to the powder in this population.
By better integrating patient characteristics when choosing dosage forms, clinicians and caregivers may improve treatment acceptability and adherence. Moreover, hospitals and healthcare institutions could optimise purchasing to best suit their local population, disseminating information to help staff align specific dosage forms to targeted patients.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0221261</identifier><identifier>PMID: 31430323</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Acceptability ; Acetaminophen ; Acetaminophen - administration & dosage ; Administration, Oral ; Adolescent ; Age Factors ; Aged ; Aged, 80 and over ; Aging ; Analgesics ; Analysis ; Biology and Life Sciences ; Centenarians ; Child ; Child, Preschool ; Clustering ; Data analysis ; Descriptive labeling ; Disintegration ; Dosage ; Dosage and administration ; Dosage Forms ; Dose-response relationship ; Drug dosages ; Female ; Formulations ; Galenic pharmacology ; Geriatrics ; Health aspects ; Hospitals ; Humans ; Infant ; Infant, Newborn ; Infants ; Innovations ; Life Sciences ; Local population ; Mapping ; Medication Adherence ; Medicine ; Medicine and Health Sciences ; Methods ; Nursing homes ; Older people ; Oldest old people ; Paracetamol ; Patients ; Pediatrics ; People and Places ; Pharmaceutical sciences ; Pharmaceuticals ; Pharmacology ; Physical Sciences ; Population ; Populations ; Powder ; Product development ; Prospective Studies ; Swallowing ; Tablets ; Vulnerable Populations</subject><ispartof>PloS one, 2019-08, Vol.14 (8), p.e0221261-e0221261</ispartof><rights>COPYRIGHT 2019 Public Library of Science</rights><rights>2019 Ruiz et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><rights>2019 Ruiz et al 2019 Ruiz et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c726t-4274c3962a45e53dc15366ed53328e11bd0c8a3b49af6797bcad2fe4b1a523613</citedby><cites>FETCH-LOGICAL-c726t-4274c3962a45e53dc15366ed53328e11bd0c8a3b49af6797bcad2fe4b1a523613</cites><orcidid>0000-0001-9167-0189</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6701828/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6701828/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,865,886,2103,2929,23871,27929,27930,53796,53798</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31430323$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://cnrs.hal.science/hal-03290585$$DView record in HAL$$Hfree_for_read</backlink></links><search><contributor>Surbhi, Satya</contributor><creatorcontrib>Ruiz, Fabrice</creatorcontrib><creatorcontrib>Vallet, Thibault</creatorcontrib><creatorcontrib>Dufaÿ Wojcicki, Amélie</creatorcontrib><creatorcontrib>Belissa, Émilie</creatorcontrib><creatorcontrib>Fontan, Jean-Eudes</creatorcontrib><creatorcontrib>de Pontual, Loïc</creatorcontrib><creatorcontrib>Nathanson, Sylvie</creatorcontrib><creatorcontrib>Chevallier, Alain</creatorcontrib><creatorcontrib>Laribe-Caget, Sandra</creatorcontrib><creatorcontrib>Boudy, Vincent</creatorcontrib><title>Dosage form suitability in vulnerable populations: A focus on paracetamol acceptability from infants to centenarians</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Medicine acceptability is a multi-faceted concept driven by both product and user characteristics. Although a key factor for treatment effectiveness, especially in vulnerable populations, knowledge of those medicine features that best promote individual user acceptability remains fragmented. Focusing on paracetamol, this study has explored the appropriateness of pharmaceutical products in different dosage forms to achieve adequate patient acceptability from infants to centenarians.
This observational, multicentre, prospective study was carried out in 10 hospitals, 8 nursing homes and over 150 community dispensaries. Observers reported several behaviours/events evaluating acceptability for 1016 different pharmaceutical product uses in paediatrics (<18y.) and 1288 in the elderly (≥65y.). Using mapping and clustering, a multivariate approach offered an intelligible reference framework for each population, providing comprehensive scores: positively or negatively accepted.
Among all the evaluations supporting the acceptability reference frameworks, there were 502 reports on paracetamol products intake. Herein we focused on the 5 products with ≥30 evaluations. Although oral suspension and powder for oral solution were positively-accepted in the paediatric group, the powder had a higher rate of negative patient reaction (p<0.001). Of those that received this formulation, 72% were ≤8y., and therefore suitable to receive the better accepted oral suspension. In the elderly, patients with swallowing disorders were preferentially treated with such powders (p<0.001), which were less often fully taken than orally disintegrating tablets (p<0.001). Even in those patients ≥90y., capsule formulations appeared to be the best accepted product in patients without swallowing alterations, and thus could be a suitable alternative to the powder in this population.
By better integrating patient characteristics when choosing dosage forms, clinicians and caregivers may improve treatment acceptability and adherence. Moreover, hospitals and healthcare institutions could optimise purchasing to best suit their local population, disseminating information to help staff align specific dosage forms to targeted patients.</description><subject>Acceptability</subject><subject>Acetaminophen</subject><subject>Acetaminophen - administration & dosage</subject><subject>Administration, Oral</subject><subject>Adolescent</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Aging</subject><subject>Analgesics</subject><subject>Analysis</subject><subject>Biology and Life Sciences</subject><subject>Centenarians</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Clustering</subject><subject>Data analysis</subject><subject>Descriptive labeling</subject><subject>Disintegration</subject><subject>Dosage</subject><subject>Dosage and administration</subject><subject>Dosage Forms</subject><subject>Dose-response relationship</subject><subject>Drug dosages</subject><subject>Female</subject><subject>Formulations</subject><subject>Galenic pharmacology</subject><subject>Geriatrics</subject><subject>Health aspects</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Infants</subject><subject>Innovations</subject><subject>Life Sciences</subject><subject>Local population</subject><subject>Mapping</subject><subject>Medication Adherence</subject><subject>Medicine</subject><subject>Medicine and Health Sciences</subject><subject>Methods</subject><subject>Nursing homes</subject><subject>Older people</subject><subject>Oldest old people</subject><subject>Paracetamol</subject><subject>Patients</subject><subject>Pediatrics</subject><subject>People and Places</subject><subject>Pharmaceutical sciences</subject><subject>Pharmaceuticals</subject><subject>Pharmacology</subject><subject>Physical Sciences</subject><subject>Population</subject><subject>Populations</subject><subject>Powder</subject><subject>Product development</subject><subject>Prospective Studies</subject><subject>Swallowing</subject><subject>Tablets</subject><subject>Vulnerable 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form suitability in vulnerable populations: A focus on paracetamol acceptability from infants to centenarians</title><author>Ruiz, Fabrice ; Vallet, Thibault ; Dufaÿ Wojcicki, Amélie ; Belissa, Émilie ; Fontan, Jean-Eudes ; de Pontual, Loïc ; Nathanson, Sylvie ; Chevallier, Alain ; Laribe-Caget, Sandra ; Boudy, Vincent</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c726t-4274c3962a45e53dc15366ed53328e11bd0c8a3b49af6797bcad2fe4b1a523613</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Acceptability</topic><topic>Acetaminophen</topic><topic>Acetaminophen - administration & dosage</topic><topic>Administration, Oral</topic><topic>Adolescent</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Aging</topic><topic>Analgesics</topic><topic>Analysis</topic><topic>Biology and Life Sciences</topic><topic>Centenarians</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Clustering</topic><topic>Data analysis</topic><topic>Descriptive labeling</topic><topic>Disintegration</topic><topic>Dosage</topic><topic>Dosage and administration</topic><topic>Dosage Forms</topic><topic>Dose-response relationship</topic><topic>Drug dosages</topic><topic>Female</topic><topic>Formulations</topic><topic>Galenic pharmacology</topic><topic>Geriatrics</topic><topic>Health aspects</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Infants</topic><topic>Innovations</topic><topic>Life Sciences</topic><topic>Local population</topic><topic>Mapping</topic><topic>Medication Adherence</topic><topic>Medicine</topic><topic>Medicine and Health Sciences</topic><topic>Methods</topic><topic>Nursing homes</topic><topic>Older people</topic><topic>Oldest old people</topic><topic>Paracetamol</topic><topic>Patients</topic><topic>Pediatrics</topic><topic>People and Places</topic><topic>Pharmaceutical sciences</topic><topic>Pharmaceuticals</topic><topic>Pharmacology</topic><topic>Physical Sciences</topic><topic>Population</topic><topic>Populations</topic><topic>Powder</topic><topic>Product development</topic><topic>Prospective Studies</topic><topic>Swallowing</topic><topic>Tablets</topic><topic>Vulnerable Populations</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ruiz, Fabrice</creatorcontrib><creatorcontrib>Vallet, Thibault</creatorcontrib><creatorcontrib>Dufaÿ Wojcicki, Amélie</creatorcontrib><creatorcontrib>Belissa, Émilie</creatorcontrib><creatorcontrib>Fontan, Jean-Eudes</creatorcontrib><creatorcontrib>de Pontual, Loïc</creatorcontrib><creatorcontrib>Nathanson, Sylvie</creatorcontrib><creatorcontrib>Chevallier, Alain</creatorcontrib><creatorcontrib>Laribe-Caget, 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Jean-Eudes</au><au>de Pontual, Loïc</au><au>Nathanson, Sylvie</au><au>Chevallier, Alain</au><au>Laribe-Caget, Sandra</au><au>Boudy, Vincent</au><au>Surbhi, Satya</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dosage form suitability in vulnerable populations: A focus on paracetamol acceptability from infants to centenarians</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2019-08-20</date><risdate>2019</risdate><volume>14</volume><issue>8</issue><spage>e0221261</spage><epage>e0221261</epage><pages>e0221261-e0221261</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Medicine acceptability is a multi-faceted concept driven by both product and user characteristics. Although a key factor for treatment effectiveness, especially in vulnerable populations, knowledge of those medicine features that best promote individual user acceptability remains fragmented. Focusing on paracetamol, this study has explored the appropriateness of pharmaceutical products in different dosage forms to achieve adequate patient acceptability from infants to centenarians.
This observational, multicentre, prospective study was carried out in 10 hospitals, 8 nursing homes and over 150 community dispensaries. Observers reported several behaviours/events evaluating acceptability for 1016 different pharmaceutical product uses in paediatrics (<18y.) and 1288 in the elderly (≥65y.). Using mapping and clustering, a multivariate approach offered an intelligible reference framework for each population, providing comprehensive scores: positively or negatively accepted.
Among all the evaluations supporting the acceptability reference frameworks, there were 502 reports on paracetamol products intake. Herein we focused on the 5 products with ≥30 evaluations. Although oral suspension and powder for oral solution were positively-accepted in the paediatric group, the powder had a higher rate of negative patient reaction (p<0.001). Of those that received this formulation, 72% were ≤8y., and therefore suitable to receive the better accepted oral suspension. In the elderly, patients with swallowing disorders were preferentially treated with such powders (p<0.001), which were less often fully taken than orally disintegrating tablets (p<0.001). Even in those patients ≥90y., capsule formulations appeared to be the best accepted product in patients without swallowing alterations, and thus could be a suitable alternative to the powder in this population.
By better integrating patient characteristics when choosing dosage forms, clinicians and caregivers may improve treatment acceptability and adherence. Moreover, hospitals and healthcare institutions could optimise purchasing to best suit their local population, disseminating information to help staff align specific dosage forms to targeted patients.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>31430323</pmid><doi>10.1371/journal.pone.0221261</doi><tpages>e0221261</tpages><orcidid>https://orcid.org/0000-0001-9167-0189</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2019-08, Vol.14 (8), p.e0221261-e0221261 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_2276833084 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Acceptability Acetaminophen Acetaminophen - administration & dosage Administration, Oral Adolescent Age Factors Aged Aged, 80 and over Aging Analgesics Analysis Biology and Life Sciences Centenarians Child Child, Preschool Clustering Data analysis Descriptive labeling Disintegration Dosage Dosage and administration Dosage Forms Dose-response relationship Drug dosages Female Formulations Galenic pharmacology Geriatrics Health aspects Hospitals Humans Infant Infant, Newborn Infants Innovations Life Sciences Local population Mapping Medication Adherence Medicine Medicine and Health Sciences Methods Nursing homes Older people Oldest old people Paracetamol Patients Pediatrics People and Places Pharmaceutical sciences Pharmaceuticals Pharmacology Physical Sciences Population Populations Powder Product development Prospective Studies Swallowing Tablets Vulnerable Populations |
| title | Dosage form suitability in vulnerable populations: A focus on paracetamol acceptability from infants to centenarians |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-11T09%3A33%3A52IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Dosage%20form%20suitability%20in%20vulnerable%20populations:%20A%20focus%20on%20paracetamol%20acceptability%20from%20infants%20to%20centenarians&rft.jtitle=PloS%20one&rft.au=Ruiz,%20Fabrice&rft.date=2019-08-20&rft.volume=14&rft.issue=8&rft.spage=e0221261&rft.epage=e0221261&rft.pages=e0221261-e0221261&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0221261&rft_dat=%3Cgale_plos_%3EA596936958%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2276833084&rft_id=info:pmid/31430323&rft_galeid=A596936958&rft_doaj_id=oai_doaj_org_article_4ed9baf806ca493fb23d16f00e05e019&rfr_iscdi=true |