The combination of ACE I/D and ACE2 G8790A polymorphisms revels susceptibility to hypertension: A genetic association study in Brazilian patients

Systemic arterial hypertension (SAH) is a multifactorial condition that already affects one third of the worldwide population. The identification of candidate genes for hypertension is a challenge for the next years. Nevertheless, the small contribution of each individual genetic factor to the disea...

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Veröffentlicht in:	PloS one 2019-08, Vol.14 (8), p.e0221248-e0221248
Hauptverfasser:	Pinheiro, Denise S, Santos, Rodrigo S, Jardim, Paulo C B Veiga, Silva, Elisangela G, Reis, Angela A S, Pedrino, Gustavo R, Ulhoa, Cirano J
Format:	Artikel
Sprache:	eng
Schlagworte:	ACE protein ACE2 ACE2 gene Adult Age Age composition Age Factors Aged Aged, 80 and over Alcoholic beverages Aldosterone Alleles Angiotensin Angiotensin I Angiotensin-converting enzyme 2 Angiotensins Antihypertensives Biochemistry Biology and Life Sciences Blood pressure Blood Pressure - genetics Body mass Body mass index Body size Brazil - epidemiology Cardiovascular disease Cardiovascular diseases Care and treatment Carriers Case-Control Studies Cholesterol Complications and side effects Diabetes Diabetes mellitus Disease susceptibility Drinking (Alcoholic beverages) Dyslipidemias - epidemiology Dyslipidemias - genetics Enzymes Female Follow-Up Studies Gender Gene deletion Gene Frequency Gene polymorphism Genes Genetic Association Studies Genetic polymorphisms Genetic Predisposition to Disease Genetic research Genotypes Glucocorticoids Homogeneity Humans Hypertension Hypertension - epidemiology Hypertension - genetics INDEL Mutation Insertion Lipids Lipoproteins (very low density) Male Mathematical analysis Medical research Medicine and Health Sciences Metabolic disorders Middle Aged Molecular biology Nucleotides People and places Peptides Peptidyl-Dipeptidase A - genetics Polymorphism Polymorphism, Single Nucleotide Regulators Renin Risk Factors Sex Factors Single nucleotide polymorphisms Single-nucleotide polymorphism Smoking Stroke Studies Triglycerides Vasoactive agents Young Adult
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