Characterization of human FcεRIα chain expression and gene copy number in humanized rat basophilic leukaemia (RBL) reporter cell lines

Several laboratories have created rat basophil leukemia (RBL) cell lines stably transfected with the human high affinity IgE receptor (FcεRIH). More recently, humanized RBL cell lines saw the introduction of reporter genes such as luciferase (RS-ATL8) and DsRed (RBL NFAT-DsRed). These reporters are...

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Veröffentlicht in:	PloS one 2019-08, Vol.14 (8), p.e0221034-e0221034
Hauptverfasser:	Ali, Eman Ali, Kalli, Marina, Wan, Daniel, Nakamura, Ryosuke, Onion, David, Alanine, Daniel G W, Alcocer, Marcos J C, Falcone, Franco H
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergies Animals Biology and Life Sciences Biotechnology Calibration Cell Line, Tumor Cell surface Chains Copy number Diagnostic software Diagnostic systems Endoplasmic reticulum Flow cytometry Gene Dosage Gene expression Gene Expression Profiling Genes Genes, Immunoglobulin Heavy Chain - genetics Genes, Reporter - genetics Immunoglobulin E Immunoglobulin gamma-Chains - genetics Immunoglobulin gamma-Chains - metabolism Immunoglobulins Leukemia Leukemia, Basophilic, Acute - genetics Leukemia, Basophilic, Acute - pathology Microspheres Monoclonal antibodies mRNA NF-AT protein Parameter sensitivity Pharmacy Rats Receptors Receptors, IgE - genetics Receptors, IgE - metabolism Research and Analysis Methods Sensitivity Transfection Tumor cell lines
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