Delayed death in the malaria parasite Plasmodium falciparum is caused by disruption of prenylation-dependent intracellular trafficking

Apicomplexan parasites possess a plastid organelle called the apicoplast. Inhibitors that selectively target apicoplast housekeeping functions, including DNA replication and protein translation, are lethal for the parasite, and several (doxycycline, clindamycin, and azithromycin) are in clinical use...

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Veröffentlicht in:	PLoS biology 2019-07, Vol.17 (7), p.e3000376-e3000376
Hauptverfasser:	Kennedy, Kit, Cobbold, Simon A, Hanssen, Eric, Birnbaum, Jakob, Spillman, Natalie J, McHugh, Emma, Brown, Hannah, Tilley, Leann, Spielmann, Tobias, McConville, Malcolm J, Ralph, Stuart A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibiotics Antimalarials - pharmacology Apicoplasts Apicoplasts - metabolism Azithromycin Biochemistry Biology and Life Sciences Biotechnology Blood Causes of Cell Death - drug effects Cell organelles Clindamycin Control Death Defects Deoxyribonucleic acid Depletion Disruption DNA DNA biosynthesis Doxycycline Drug development Drugs Electron microscopy Erythrocytes Genomes Hemiterpenes - metabolism Hemiterpenes - pharmacology Humans Immunology Intracellular Space - drug effects Intracellular Space - metabolism Intracellular Space - parasitology Invaginations Malaria Malaria, Falciparum - parasitology Medicine and Health Sciences Membrane trafficking Metabolomics Metabolomics - methods Microscopy Molecular biology Mortality Organophosphorus Compounds - metabolism Organophosphorus Compounds - pharmacology Parasites Phenotypes Physical Sciences Physiological aspects Plasmodium falciparum Plasmodium falciparum - drug effects Plasmodium falciparum - metabolism Plasmodium falciparum - physiology Plastids Precursors Protein Prenylation - drug effects Protein Transport - drug effects Proteins Protozoan Proteins - metabolism Supervision Terpenes Terpenoids Vacuoles - drug effects Vacuoles - metabolism Vacuoles - parasitology Vector-borne diseases
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