The demethylase NMAD-1 regulates DNA replication and repair in the Caenorhabditis elegans germline

The biological roles of nucleic acid methylation, other than at the C5-position of cytosines in CpG dinucleotides, are still not well understood. Here, we report genetic evidence for a critical role for the putative DNA demethylase NMAD-1 in regulating meiosis in C. elegans. nmad-1 mutants have redu...

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Veröffentlicht in:	PLoS genetics 2019-07, Vol.15 (7), p.e1008252-e1008252
Hauptverfasser:	Wang, Simon Yuan, Mao, Hui, Shibuya, Hiroki, Uzawa, Satoru, O'Brown, Zach Klapholz, Wesenberg, Sage, Shin, Nara, Saito, Takamune T, Gao, Jinmin, Meyer, Barbara J, Colaiácovo, Monica P, Greer, Eric Lieberman
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Biological Sciences Biologiska vetenskaper Biology and life sciences Caenorhabditis elegans Caenorhabditis elegans Proteins - genetics Caenorhabditis elegans Proteins - metabolism Cell cycle Chromatin Chromosome Segregation Chromosomes Cohesin CpG islands Deoxyribonucleic acid Developmental biology Dioxygenases - genetics Dioxygenases - metabolism DNA DNA biosynthesis DNA damage DNA demethylase DNA methylation DNA Repair DNA Replication DNA sequencing Families & family life Fertility Funding Genetic aspects Genetics Genetik Immunoprecipitation Infertility Male Mass spectroscopy Medical schools Medicine Medicine and Health Sciences Meiosis Methylation Mitochondrial DNA Mutation Nematodes Observations Oocytes Oxidoreductases, N-Demethylating - genetics Oxidoreductases, N-Demethylating - metabolism Pediatrics Physiological aspects Prophase Replication Research and Analysis Methods Ribonucleic acid RNA Sequence Analysis, RNA Supervision Worms Zygotene
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