Leptin and adiponectin dynamics at patients with rectal neoplasm - Gender differences
Numerous studies associate adipokines with colorectal malignancy, but few data deal with patients suffering exclusively of rectal carcinoma (RC). We evaluated leptin and adiponectin levels in RC patients compared to healthy population and their dynamics after surgery. Serum leptin and adiponectin we...
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| Veröffentlicht in: | PloS one 2019-08, Vol.14 (8), p.e0212471-e0212471 |
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| creator | Florescu, Alexandru Branisteanu, Dumitru Bilha, Stefana Scripcariu, Dragos Florescu, Ioana Scripcariu, Viorel Dimofte, Gabriel Grigoras, Ioana |
| description | Numerous studies associate adipokines with colorectal malignancy, but few data deal with patients suffering exclusively of rectal carcinoma (RC).
We evaluated leptin and adiponectin levels in RC patients compared to healthy population and their dynamics after surgery.
Serum leptin and adiponectin were evaluated before surgery in 59 RC consecutive patients (38 males and 21 females), and in age and weight matched healthy controls. Measurements were repeated at 24, 72 hours and 7 days after surgery.
Adipokine levels were higher in women. Controls had higher leptin (32.±4.34 vs 9.51±1.73 ng/ml in women and 11±2.66 vs 2.54±0.39 ng/ml in men, p = 0.00048 and 0.0032) and lower adiponectin (9±0.64 vs 11.85±1.02 μg/ml in women and 7.39±0.51 vs 8.5±0.62 μg/ml in men, p = 0.017 and 0.019) than RC patients. Surgery caused an increase of leptin from 5.11±0.8 to 18.7±2.42 ng/ml, p = 6.85 x 10¨8, and a decrease of adiponectin from 9.71±0.58 to 7.87±0.47 μg/ml, p = 1.4 x 10¨10 for all RC patients and returned thereafter to the initial range at 7 days. Adipokines were correlated with body weight (BW). The significance of correlation persisted after surgery only in males, but disappeared in females. Adipokines were not modified by tumor position, presurgical chemoradiotherapy or surgical technique. Women with RC experiencing weight loss had higher adiponectin than women without weight modifications (p |
| doi_str_mv | 10.1371/journal.pone.0212471 |
| format | Article |
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We evaluated leptin and adiponectin levels in RC patients compared to healthy population and their dynamics after surgery.
Serum leptin and adiponectin were evaluated before surgery in 59 RC consecutive patients (38 males and 21 females), and in age and weight matched healthy controls. Measurements were repeated at 24, 72 hours and 7 days after surgery.
Adipokine levels were higher in women. Controls had higher leptin (32.±4.34 vs 9.51±1.73 ng/ml in women and 11±2.66 vs 2.54±0.39 ng/ml in men, p = 0.00048 and 0.0032) and lower adiponectin (9±0.64 vs 11.85±1.02 μg/ml in women and 7.39±0.51 vs 8.5±0.62 μg/ml in men, p = 0.017 and 0.019) than RC patients. Surgery caused an increase of leptin from 5.11±0.8 to 18.7±2.42 ng/ml, p = 6.85 x 10¨8, and a decrease of adiponectin from 9.71±0.58 to 7.87±0.47 μg/ml, p = 1.4 x 10¨10 for all RC patients and returned thereafter to the initial range at 7 days. Adipokines were correlated with body weight (BW). The significance of correlation persisted after surgery only in males, but disappeared in females. Adipokines were not modified by tumor position, presurgical chemoradiotherapy or surgical technique. Women with RC experiencing weight loss had higher adiponectin than women without weight modifications (p<0.05 at all time points).
Adipokine levels of patients with RC differ from the healthy population, possibly reflecting an adaptation to disease. Adipokine modifications after surgery may be related to acute surgical stress. Whether leptin and adiponectin directly interact is not clear. Women have higher adipokine levels, more so after significant weight loss, but the strength of their correlation with BW decreases after surgery. These data suggest gender differences in the adipokine profile of RC patients which may find clinical applications.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0212471</identifier><identifier>PMID: 31425509</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adiponectin ; Adiponectin - blood ; Adipose tissue ; Aged ; Angiogenesis ; Biology and Life Sciences ; Biomarkers, Tumor - blood ; Body Weight ; Body weight loss ; Carcinoma ; Care and treatment ; Case-Control Studies ; Chemoradiotherapy ; Colorectal cancer ; Composition ; Correlation ; Diabetes ; Endocrinology ; Female ; Females ; Gender aspects ; Gender differences ; Health aspects ; Humans ; Insulin resistance ; Intensive care ; Leptin ; Leptin - blood ; Male ; Males ; Malignancy ; Measurement ; Medicine ; Medicine and Health Sciences ; Men ; Middle Aged ; Patient outcomes ; Patients ; Pharmacy ; Protein hormones ; Rectal Neoplasms - blood ; Rectal Neoplasms - pathology ; Rectal Neoplasms - surgery ; Rectum ; Sex differences ; Sex Factors ; Stress, Physiological ; Surgery ; Systematic review ; Therapeutic applications ; Tumors ; Weight control ; Weight Loss ; Women</subject><ispartof>PloS one, 2019-08, Vol.14 (8), p.e0212471-e0212471</ispartof><rights>COPYRIGHT 2019 Public Library of Science</rights><rights>2019 Florescu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2019 Florescu et al 2019 Florescu et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-a8892bc8c3ec99a84fe93bfec2cb612f9cbb0232cea3865480a683112cef88a43</citedby><cites>FETCH-LOGICAL-c692t-a8892bc8c3ec99a84fe93bfec2cb612f9cbb0232cea3865480a683112cef88a43</cites><orcidid>0000-0001-8610-1416</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6699797/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6699797/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23847,27903,27904,53769,53771,79346,79347</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31425509$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Vodickova, Ludmila</contributor><creatorcontrib>Florescu, Alexandru</creatorcontrib><creatorcontrib>Branisteanu, Dumitru</creatorcontrib><creatorcontrib>Bilha, Stefana</creatorcontrib><creatorcontrib>Scripcariu, Dragos</creatorcontrib><creatorcontrib>Florescu, Ioana</creatorcontrib><creatorcontrib>Scripcariu, Viorel</creatorcontrib><creatorcontrib>Dimofte, Gabriel</creatorcontrib><creatorcontrib>Grigoras, Ioana</creatorcontrib><title>Leptin and adiponectin dynamics at patients with rectal neoplasm - Gender differences</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Numerous studies associate adipokines with colorectal malignancy, but few data deal with patients suffering exclusively of rectal carcinoma (RC).
We evaluated leptin and adiponectin levels in RC patients compared to healthy population and their dynamics after surgery.
Serum leptin and adiponectin were evaluated before surgery in 59 RC consecutive patients (38 males and 21 females), and in age and weight matched healthy controls. Measurements were repeated at 24, 72 hours and 7 days after surgery.
Adipokine levels were higher in women. Controls had higher leptin (32.±4.34 vs 9.51±1.73 ng/ml in women and 11±2.66 vs 2.54±0.39 ng/ml in men, p = 0.00048 and 0.0032) and lower adiponectin (9±0.64 vs 11.85±1.02 μg/ml in women and 7.39±0.51 vs 8.5±0.62 μg/ml in men, p = 0.017 and 0.019) than RC patients. Surgery caused an increase of leptin from 5.11±0.8 to 18.7±2.42 ng/ml, p = 6.85 x 10¨8, and a decrease of adiponectin from 9.71±0.58 to 7.87±0.47 μg/ml, p = 1.4 x 10¨10 for all RC patients and returned thereafter to the initial range at 7 days. Adipokines were correlated with body weight (BW). The significance of correlation persisted after surgery only in males, but disappeared in females. Adipokines were not modified by tumor position, presurgical chemoradiotherapy or surgical technique. Women with RC experiencing weight loss had higher adiponectin than women without weight modifications (p<0.05 at all time points).
Adipokine levels of patients with RC differ from the healthy population, possibly reflecting an adaptation to disease. Adipokine modifications after surgery may be related to acute surgical stress. Whether leptin and adiponectin directly interact is not clear. Women have higher adipokine levels, more so after significant weight loss, but the strength of their correlation with BW decreases after surgery. These data suggest gender differences in the adipokine profile of RC patients which may find clinical applications.</description><subject>Adiponectin</subject><subject>Adiponectin - blood</subject><subject>Adipose tissue</subject><subject>Aged</subject><subject>Angiogenesis</subject><subject>Biology and Life Sciences</subject><subject>Biomarkers, Tumor - blood</subject><subject>Body Weight</subject><subject>Body weight loss</subject><subject>Carcinoma</subject><subject>Care and treatment</subject><subject>Case-Control Studies</subject><subject>Chemoradiotherapy</subject><subject>Colorectal cancer</subject><subject>Composition</subject><subject>Correlation</subject><subject>Diabetes</subject><subject>Endocrinology</subject><subject>Female</subject><subject>Females</subject><subject>Gender aspects</subject><subject>Gender differences</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Insulin resistance</subject><subject>Intensive care</subject><subject>Leptin</subject><subject>Leptin - blood</subject><subject>Male</subject><subject>Males</subject><subject>Malignancy</subject><subject>Measurement</subject><subject>Medicine</subject><subject>Medicine and Health Sciences</subject><subject>Men</subject><subject>Middle Aged</subject><subject>Patient outcomes</subject><subject>Patients</subject><subject>Pharmacy</subject><subject>Protein hormones</subject><subject>Rectal Neoplasms - blood</subject><subject>Rectal Neoplasms - pathology</subject><subject>Rectal Neoplasms - surgery</subject><subject>Rectum</subject><subject>Sex differences</subject><subject>Sex Factors</subject><subject>Stress, Physiological</subject><subject>Surgery</subject><subject>Systematic review</subject><subject>Therapeutic applications</subject><subject>Tumors</subject><subject>Weight control</subject><subject>Weight Loss</subject><subject>Women</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNkk1v1DAQhiMEoqXwDxBEQkJw2MXfsS9IVQVlpZUqAeVqTRxn16usncYJ0H-Pw6bVBvWAcnA8fuYd-53JspcYLTEt8IddGDoPzbIN3i4RwYQV-FF2ihUlC0EQfXz0f5I9i3GHEKdSiKfZCcWMcI7UaXa9tm3vfA6-yqFyo5gZ99Wth70zMYc-b6F31vcx_-X6bd4lAJrc29A2EPf5Ir-0vrJdXrm6tp31xsbn2ZMammhfTOtZdv350_eLL4v11eXq4ny9MEKRfgFSKlIaaag1SoFktVW0rK0hphSY1MqUJSKUGAvp4pxJBEJSjFOglhIYPcteH3TbJkQ9ORI1IQVXFNGCJGJ1IKoAO912bg_drQ7g9N9A6DYaut6ZxmopADHGxqqISVMBRzUvmWAEuGKFSFofp2pDubeVSZ500MxE5yfebfUm_NRCKFWoIgm8mwS6cDPY2Ou9i8Y2DSQ3h3RvSoWSWCie0Df_oA-_bqI2kB7gfB1SXTOK6nOuhBSU87Hs8gEqfZVNLU4dr12KzxLezxIS09vf_QaGGPXq29f_Z69-zNm3R-zWQtNvY2iG3gUf5yA7gKYLMXa2vjcZIz1O_50behxYPU1_Snt13KD7pLtxp38A3b3_Nw</recordid><startdate>20190819</startdate><enddate>20190819</enddate><creator>Florescu, Alexandru</creator><creator>Branisteanu, Dumitru</creator><creator>Bilha, Stefana</creator><creator>Scripcariu, Dragos</creator><creator>Florescu, Ioana</creator><creator>Scripcariu, Viorel</creator><creator>Dimofte, Gabriel</creator><creator>Grigoras, Ioana</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0001-8610-1416</orcidid></search><sort><creationdate>20190819</creationdate><title>Leptin and adiponectin dynamics at patients with rectal neoplasm - Gender differences</title><author>Florescu, Alexandru ; Branisteanu, Dumitru ; Bilha, Stefana ; Scripcariu, Dragos ; Florescu, Ioana ; Scripcariu, Viorel ; Dimofte, Gabriel ; Grigoras, Ioana</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-a8892bc8c3ec99a84fe93bfec2cb612f9cbb0232cea3865480a683112cef88a43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adiponectin</topic><topic>Adiponectin - blood</topic><topic>Adipose tissue</topic><topic>Aged</topic><topic>Angiogenesis</topic><topic>Biology and Life Sciences</topic><topic>Biomarkers, Tumor - blood</topic><topic>Body Weight</topic><topic>Body weight loss</topic><topic>Carcinoma</topic><topic>Care and treatment</topic><topic>Case-Control Studies</topic><topic>Chemoradiotherapy</topic><topic>Colorectal cancer</topic><topic>Composition</topic><topic>Correlation</topic><topic>Diabetes</topic><topic>Endocrinology</topic><topic>Female</topic><topic>Females</topic><topic>Gender aspects</topic><topic>Gender differences</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Insulin resistance</topic><topic>Intensive care</topic><topic>Leptin</topic><topic>Leptin - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Florescu, Alexandru</au><au>Branisteanu, Dumitru</au><au>Bilha, Stefana</au><au>Scripcariu, Dragos</au><au>Florescu, Ioana</au><au>Scripcariu, Viorel</au><au>Dimofte, Gabriel</au><au>Grigoras, Ioana</au><au>Vodickova, Ludmila</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Leptin and adiponectin dynamics at patients with rectal neoplasm - Gender differences</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2019-08-19</date><risdate>2019</risdate><volume>14</volume><issue>8</issue><spage>e0212471</spage><epage>e0212471</epage><pages>e0212471-e0212471</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Numerous studies associate adipokines with colorectal malignancy, but few data deal with patients suffering exclusively of rectal carcinoma (RC).
We evaluated leptin and adiponectin levels in RC patients compared to healthy population and their dynamics after surgery.
Serum leptin and adiponectin were evaluated before surgery in 59 RC consecutive patients (38 males and 21 females), and in age and weight matched healthy controls. Measurements were repeated at 24, 72 hours and 7 days after surgery.
Adipokine levels were higher in women. Controls had higher leptin (32.±4.34 vs 9.51±1.73 ng/ml in women and 11±2.66 vs 2.54±0.39 ng/ml in men, p = 0.00048 and 0.0032) and lower adiponectin (9±0.64 vs 11.85±1.02 μg/ml in women and 7.39±0.51 vs 8.5±0.62 μg/ml in men, p = 0.017 and 0.019) than RC patients. Surgery caused an increase of leptin from 5.11±0.8 to 18.7±2.42 ng/ml, p = 6.85 x 10¨8, and a decrease of adiponectin from 9.71±0.58 to 7.87±0.47 μg/ml, p = 1.4 x 10¨10 for all RC patients and returned thereafter to the initial range at 7 days. Adipokines were correlated with body weight (BW). The significance of correlation persisted after surgery only in males, but disappeared in females. Adipokines were not modified by tumor position, presurgical chemoradiotherapy or surgical technique. Women with RC experiencing weight loss had higher adiponectin than women without weight modifications (p<0.05 at all time points).
Adipokine levels of patients with RC differ from the healthy population, possibly reflecting an adaptation to disease. Adipokine modifications after surgery may be related to acute surgical stress. Whether leptin and adiponectin directly interact is not clear. Women have higher adipokine levels, more so after significant weight loss, but the strength of their correlation with BW decreases after surgery. These data suggest gender differences in the adipokine profile of RC patients which may find clinical applications.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>31425509</pmid><doi>10.1371/journal.pone.0212471</doi><tpages>e0212471</tpages><orcidid>https://orcid.org/0000-0001-8610-1416</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | PloS one, 2019-08, Vol.14 (8), p.e0212471-e0212471 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_2275930372 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry; Public Library of Science (PLoS) |
| subjects | Adiponectin Adiponectin - blood Adipose tissue Aged Angiogenesis Biology and Life Sciences Biomarkers, Tumor - blood Body Weight Body weight loss Carcinoma Care and treatment Case-Control Studies Chemoradiotherapy Colorectal cancer Composition Correlation Diabetes Endocrinology Female Females Gender aspects Gender differences Health aspects Humans Insulin resistance Intensive care Leptin Leptin - blood Male Males Malignancy Measurement Medicine Medicine and Health Sciences Men Middle Aged Patient outcomes Patients Pharmacy Protein hormones Rectal Neoplasms - blood Rectal Neoplasms - pathology Rectal Neoplasms - surgery Rectum Sex differences Sex Factors Stress, Physiological Surgery Systematic review Therapeutic applications Tumors Weight control Weight Loss Women |
| title | Leptin and adiponectin dynamics at patients with rectal neoplasm - Gender differences |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-27T15%3A37%3A35IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Leptin%20and%20adiponectin%20dynamics%20at%20patients%20with%20rectal%20neoplasm%20-%20Gender%20differences&rft.jtitle=PloS%20one&rft.au=Florescu,%20Alexandru&rft.date=2019-08-19&rft.volume=14&rft.issue=8&rft.spage=e0212471&rft.epage=e0212471&rft.pages=e0212471-e0212471&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0212471&rft_dat=%3Cgale_plos_%3EA596863557%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2275930372&rft_id=info:pmid/31425509&rft_galeid=A596863557&rft_doaj_id=oai_doaj_org_article_86a0444f9cb048cda50f5b4642a59476&rfr_iscdi=true |