Evaluation of Burkholderia mallei ΔtonB Δhcp1 (CLH001) as a live attenuated vaccine in murine models of glanders and melioidosis

Glanders caused by Burkholderia mallei is a re-emerging zoonotic disease affecting solipeds and humans. Furthermore, B. mallei is genetically related to B. pseudomallei, which is the causative agent of melioidosis. Both facultative intracellular bacteria are classified as tier 1 select biothreat age...

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Veröffentlicht in:	PLoS neglected tropical diseases 2019-07, Vol.13 (7), p.e0007578-e0007578
Hauptverfasser:	Khakhum, Nittaya, Bharaj, Preeti, Myers, Julia N, Tapia, Daniel, Walker, David H, Endsley, Janice J, Torres, Alfredo G
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Antibodies Antibodies, Bacterial - immunology Antigens Attenuation Bacteria Bacterial infections Bacterial Proteins - genetics Bacterial Proteins - immunology Bacterial Vaccines - immunology Biology and Life Sciences Body organs Burkholderia mallei Burkholderia mallei - genetics Burkholderia mallei - immunology CD4 antigen CD8 antigen CD8-Positive T-Lymphocytes - immunology Cross-protection Disease Disease control Disease Models, Animal Female Glanders Glanders - immunology Glanders - microbiology Glanders - prevention & control Humans Humoral immunity Immune response (cell-mediated) Immunity Immunity, Humoral Immunization Immunoglobulin G Immunology Infections Laboratory animals Low level Lymphocytes Lymphocytes T Medicine and Health Sciences Melioidosis Melioidosis - immunology Melioidosis - microbiology Melioidosis - prevention & control Membrane Proteins - genetics Membrane Proteins - immunology Mice Mice, Inbred BALB C Mice, Inbred C57BL Microbiological strains Organs Pathology Physical Sciences Protection Research and Analysis Methods Strains Survival Tropical diseases Vaccination Vaccines Vaccines, Attenuated - immunology Virulence Factors - genetics Virulence Factors - immunology Zoonoses γ-Interferon
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