Utility of imaging modalities for predicting carcinogenesis in lobular endocervical glandular hyperplasia
To investigate the use of imaging methods for predicting carcinogenesis in lobular endocervical glandular hyperplasia (LEGH). We retrospectively analyzed preoperative images on transvaginal sonography and magnetic resonance imaging (MRI) in 23 cases with histologically diagnosed LEGH. Shape of cervi...
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| Veröffentlicht in: | PloS one 2019-08, Vol.14 (8), p.e0221088 |
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| creator | Omori, Makiko Kondo, Tetsuo Tagaya, Hikaru Watanabe, Yumika Fukasawa, Hiroko Kawai, Masataka Nakazawa, Kumiko Hashi, Akihiko Hirata, Shuji |
| description | To investigate the use of imaging methods for predicting carcinogenesis in lobular endocervical glandular hyperplasia (LEGH).
We retrospectively analyzed preoperative images on transvaginal sonography and magnetic resonance imaging (MRI) in 23 cases with histologically diagnosed LEGH.
Shape of cervical multicystic lesions on MR images could be divided into two types the flower-type with many small cysts surrounded by larger cysts, and the raspberry-type with many tiny, closely aggregated cysts. Six (46%) of 13 cases had raspberry-type lesions that were not detected on transvaginal sonography but were seen on MRI. Adenocarcinoma in situ (AIS) was identified in 4 postmenopausal women with raspberry-type lesions during the follow-up periods. In these cases, cytologic examination by targeted endocervical sampling using sonography enabled early detection of AIS.
MRI and cytologic examination by targeted endocervical sampling may be very useful for predicting carcinogenesis in LEGH. |
| doi_str_mv | 10.1371/journal.pone.0221088 |
| format | Article |
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We retrospectively analyzed preoperative images on transvaginal sonography and magnetic resonance imaging (MRI) in 23 cases with histologically diagnosed LEGH.
Shape of cervical multicystic lesions on MR images could be divided into two types the flower-type with many small cysts surrounded by larger cysts, and the raspberry-type with many tiny, closely aggregated cysts. Six (46%) of 13 cases had raspberry-type lesions that were not detected on transvaginal sonography but were seen on MRI. Adenocarcinoma in situ (AIS) was identified in 4 postmenopausal women with raspberry-type lesions during the follow-up periods. In these cases, cytologic examination by targeted endocervical sampling using sonography enabled early detection of AIS.
MRI and cytologic examination by targeted endocervical sampling may be very useful for predicting carcinogenesis in LEGH.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0221088</identifier><identifier>PMID: 31415639</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adenocarcinoma ; Adenocarcinoma in Situ - diagnostic imaging ; Adenocarcinoma in Situ - pathology ; Adult ; Aged ; Biology and Life Sciences ; Cancer ; Cancer screening ; Carcinogenesis ; Carcinogens ; Cervical cancer ; Cervix ; Cervix Uteri - diagnostic imaging ; Cervix Uteri - pathology ; Cysts ; Diagnosis ; Diagnostic imaging ; Female ; Forecasts and trends ; Gynecology ; Human papillomavirus ; Humans ; Hyperplasia ; Lesions ; Magnetic resonance ; Magnetic Resonance Imaging ; Medical screening ; Medicine ; Medicine and Health Sciences ; Methods ; Middle Aged ; NMR ; Nuclear magnetic resonance ; Obstetrics ; Pathology ; Personal information ; Post-menopause ; Postmenopausal women ; Research and Analysis Methods ; Sampling ; Tumors ; Ultrasonic imaging ; Ultrasonography ; Ultrasound imaging ; Uterine Cervical Neoplasms - diagnostic imaging ; Uterine Cervical Neoplasms - pathology ; Womens health</subject><ispartof>PloS one, 2019-08, Vol.14 (8), p.e0221088</ispartof><rights>COPYRIGHT 2019 Public Library of Science</rights><rights>2019 Omori et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2019 Omori et al 2019 Omori et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c758t-8b9f1ad9d389f9f21bd1eec0aa45de4d46d7fae868116dc306d5aa7d005d67bb3</citedby><cites>FETCH-LOGICAL-c758t-8b9f1ad9d389f9f21bd1eec0aa45de4d46d7fae868116dc306d5aa7d005d67bb3</cites><orcidid>0000-0003-4430-5490</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6695122/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6695122/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2095,2914,23846,27903,27904,53769,53771,79346,79347</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31415639$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Angeletti, Peter C.</contributor><creatorcontrib>Omori, Makiko</creatorcontrib><creatorcontrib>Kondo, Tetsuo</creatorcontrib><creatorcontrib>Tagaya, Hikaru</creatorcontrib><creatorcontrib>Watanabe, Yumika</creatorcontrib><creatorcontrib>Fukasawa, Hiroko</creatorcontrib><creatorcontrib>Kawai, Masataka</creatorcontrib><creatorcontrib>Nakazawa, Kumiko</creatorcontrib><creatorcontrib>Hashi, Akihiko</creatorcontrib><creatorcontrib>Hirata, Shuji</creatorcontrib><title>Utility of imaging modalities for predicting carcinogenesis in lobular endocervical glandular hyperplasia</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>To investigate the use of imaging methods for predicting carcinogenesis in lobular endocervical glandular hyperplasia (LEGH).
We retrospectively analyzed preoperative images on transvaginal sonography and magnetic resonance imaging (MRI) in 23 cases with histologically diagnosed LEGH.
Shape of cervical multicystic lesions on MR images could be divided into two types the flower-type with many small cysts surrounded by larger cysts, and the raspberry-type with many tiny, closely aggregated cysts. Six (46%) of 13 cases had raspberry-type lesions that were not detected on transvaginal sonography but were seen on MRI. Adenocarcinoma in situ (AIS) was identified in 4 postmenopausal women with raspberry-type lesions during the follow-up periods. In these cases, cytologic examination by targeted endocervical sampling using sonography enabled early detection of AIS.
MRI and cytologic examination by targeted endocervical sampling may be very useful for predicting carcinogenesis in LEGH.</description><subject>Adenocarcinoma</subject><subject>Adenocarcinoma in Situ - diagnostic imaging</subject><subject>Adenocarcinoma in Situ - pathology</subject><subject>Adult</subject><subject>Aged</subject><subject>Biology and Life Sciences</subject><subject>Cancer</subject><subject>Cancer screening</subject><subject>Carcinogenesis</subject><subject>Carcinogens</subject><subject>Cervical cancer</subject><subject>Cervix</subject><subject>Cervix Uteri - diagnostic imaging</subject><subject>Cervix Uteri - pathology</subject><subject>Cysts</subject><subject>Diagnosis</subject><subject>Diagnostic imaging</subject><subject>Female</subject><subject>Forecasts and trends</subject><subject>Gynecology</subject><subject>Human papillomavirus</subject><subject>Humans</subject><subject>Hyperplasia</subject><subject>Lesions</subject><subject>Magnetic resonance</subject><subject>Magnetic Resonance Imaging</subject><subject>Medical screening</subject><subject>Medicine</subject><subject>Medicine and Health Sciences</subject><subject>Methods</subject><subject>Middle Aged</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Obstetrics</subject><subject>Pathology</subject><subject>Personal information</subject><subject>Post-menopause</subject><subject>Postmenopausal women</subject><subject>Research and Analysis Methods</subject><subject>Sampling</subject><subject>Tumors</subject><subject>Ultrasonic imaging</subject><subject>Ultrasonography</subject><subject>Ultrasound imaging</subject><subject>Uterine Cervical Neoplasms - diagnostic imaging</subject><subject>Uterine Cervical Neoplasms - pathology</subject><subject>Womens health</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNkttq3DAQhk1paQ7tG5TWUAj0YreWbUn2TSCEHhYCgbbprRhLY68WreRKdui-fbVZJ6yhhaILSaNvfs0Mf5K8IdmSFJx83LjRWzDL3llcZnlOsqp6lpySusgXLM-K50fnk-QshE2W0aJi7GVyUpCSUFbUp4m-G7TRwy51baq30GnbpVunIMY0hrR1Pu09Ki2H_YsEL7V1HVoMOqTapsY1owGfolVOor_XEkzaGbDqIbze9eh7A0HDq-RFCybg62k_T-4-f_px_XVxc_tldX11s5CcVsOiauqWgKpVUdVt3eakUQRRZgAlVViqkineAlasIoQpWWRMUQCuYnOK8aYpzpN3B93euCCmKQWR57zgJed1HYnVgVAONqL3sW-_Ew60eAg43wnwg5YGBSioGloikw2WmEmQmWp4zSFeVClp1LqcfhubLSqJdvBgZqLzF6vXonP3grGakjyPAu8nAe9-jRiGf5Q8UR3EqrRtXRSTWx2kuKI1oznlFY_U8i9UXAq3WkaftDrGZwkfZgmRGfD30MEYglh9__b_7O3POXtxxK4RzLAOzoyDdjbMwfIASu9C8Ng-TY5kYm_zx2mIvc3FZPOY9vZ46k9Jj74u_gA1hvxj</recordid><startdate>20190815</startdate><enddate>20190815</enddate><creator>Omori, Makiko</creator><creator>Kondo, Tetsuo</creator><creator>Tagaya, Hikaru</creator><creator>Watanabe, Yumika</creator><creator>Fukasawa, Hiroko</creator><creator>Kawai, Masataka</creator><creator>Nakazawa, Kumiko</creator><creator>Hashi, Akihiko</creator><creator>Hirata, Shuji</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0003-4430-5490</orcidid></search><sort><creationdate>20190815</creationdate><title>Utility of imaging modalities for predicting carcinogenesis in lobular endocervical glandular hyperplasia</title><author>Omori, Makiko ; Kondo, Tetsuo ; Tagaya, Hikaru ; Watanabe, Yumika ; Fukasawa, Hiroko ; Kawai, Masataka ; Nakazawa, Kumiko ; Hashi, Akihiko ; Hirata, Shuji</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c758t-8b9f1ad9d389f9f21bd1eec0aa45de4d46d7fae868116dc306d5aa7d005d67bb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adenocarcinoma</topic><topic>Adenocarcinoma in Situ - 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We retrospectively analyzed preoperative images on transvaginal sonography and magnetic resonance imaging (MRI) in 23 cases with histologically diagnosed LEGH.
Shape of cervical multicystic lesions on MR images could be divided into two types the flower-type with many small cysts surrounded by larger cysts, and the raspberry-type with many tiny, closely aggregated cysts. Six (46%) of 13 cases had raspberry-type lesions that were not detected on transvaginal sonography but were seen on MRI. Adenocarcinoma in situ (AIS) was identified in 4 postmenopausal women with raspberry-type lesions during the follow-up periods. In these cases, cytologic examination by targeted endocervical sampling using sonography enabled early detection of AIS.
MRI and cytologic examination by targeted endocervical sampling may be very useful for predicting carcinogenesis in LEGH.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>31415639</pmid><doi>10.1371/journal.pone.0221088</doi><tpages>e0221088</tpages><orcidid>https://orcid.org/0000-0003-4430-5490</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adenocarcinoma Adenocarcinoma in Situ - diagnostic imaging Adenocarcinoma in Situ - pathology Adult Aged Biology and Life Sciences Cancer Cancer screening Carcinogenesis Carcinogens Cervical cancer Cervix Cervix Uteri - diagnostic imaging Cervix Uteri - pathology Cysts Diagnosis Diagnostic imaging Female Forecasts and trends Gynecology Human papillomavirus Humans Hyperplasia Lesions Magnetic resonance Magnetic Resonance Imaging Medical screening Medicine Medicine and Health Sciences Methods Middle Aged NMR Nuclear magnetic resonance Obstetrics Pathology Personal information Post-menopause Postmenopausal women Research and Analysis Methods Sampling Tumors Ultrasonic imaging Ultrasonography Ultrasound imaging Uterine Cervical Neoplasms - diagnostic imaging Uterine Cervical Neoplasms - pathology Womens health |
| title | Utility of imaging modalities for predicting carcinogenesis in lobular endocervical glandular hyperplasia |
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