Acylcarnitine profiling by low-resolution LC-MS

Acylcarnitines are fatty acyl esters of L-carnitine and facilitate the entry of long-chain fatty acids into mitochondria via the carnitine shuttle, where they are metabolized via ß-oxidation. Alterations of acylcarnitine species can be diagnostic for fatty acid oxidation disorders and organic acidur...

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Veröffentlicht in:	PloS one 2019-08, Vol.14 (8), p.e0221342-e0221342
1. Verfasser:	Meierhofer, David
Format:	Artikel
Sprache:	eng
Schlagworte:	Aciduria Animals Biology and Life Sciences Carbon Carnitine Carnitine - analogs & derivatives Carnitine - analysis Carnitine - chemistry Carnitine - metabolism Chromatography Chromatography, Liquid Composition Criminal investigation Diabetes Diagnostic systems Elution Engineering and Technology Esters Fatty acids Health aspects L-Carnitine Levocarnitine Lipids Liquid chromatography Mass Spectrometry Mass spectroscopy Medicine and Health Sciences Metabolism Metabolites Methods Mice Mitochondria Mutation Neonates Newborn infants Organic chemistry Oxidation Oxidation-reduction reactions Physical Sciences Research and Analysis Methods Scientific imaging Species Spectroscopy Testing
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