CRISPR-Cas9 mediated CD133 knockout inhibits colon cancer invasion through reduced epithelial-mesenchymal transition

We previously reported that CD133, as a putative cancer stem cell marker, plays an important role in cell proliferation and invasion in colon cancer. To understand the role of CD133 expression in colon cancer, we evaluated the inhibitory effect of CD133 in colon cancer cells. In this study, we gener...

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Veröffentlicht in:	PloS one 2019-08, Vol.14 (8), p.e0220860-e0220860
Hauptverfasser:	Li, Wanlu, Cho, Mee-Yon, Lee, Suji, Jang, Mirae, Park, Junsoo, Park, Rackhyun
Format:	Artikel
Sprache:	eng
Schlagworte:	AC133 Antigen - deficiency AC133 Antigen - genetics AC133 Antigen - pharmacology Anticancer properties Biology and Life Sciences Cancer cells Cancer research Care and treatment Cell adhesion & migration Cell differentiation Cell growth Cell migration Cell Proliferation Colon Colon cancer Colonic Neoplasms - genetics Colonic Neoplasms - pathology Colonic Neoplasms - therapy Colonies Colorectal cancer CRISPR CRISPR-Cas Systems - genetics CRISPR-Cas technology Cyclic S-Oxides - pharmacology EDTA Engineering and Technology Epithelial-Mesenchymal Transition - genetics Flow cytometry Gene Knockout Techniques - methods Genes Genetic aspects Genetic modification Genome editing Genomes gRNA Health aspects Humans Medicine Medicine and Health Sciences Mesenchyme Metastasis Methylene blue Neoplasm Invasiveness - prevention & control Neoplastic Stem Cells Pathology Social Sciences Stem cells Testing Tumor Cells, Cultured Vimentin Vimentin - metabolism
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