Knockout of Babesia bovis rad51 ortholog and its complementation by expression from the BbACc3 artificial chromosome platform

Babesia bovis establishes persistent infections of long duration in cattle, despite the development of effective anti-disease immunity. One mechanism used by the parasite to achieve persistence is rapid antigenic variation of the VESA1 cytoadhesion ligand through segmental gene conversion (SGC), a p...

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Veröffentlicht in:	PloS one 2019-08, Vol.14 (8), p.e0215882
Hauptverfasser:	Mack, Erin A, Xiao, Yu-Ping, Allred, David R
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Antigens Artificial chromosomes Babesia Babesia bovis Babesia bovis - enzymology Babesia bovis - genetics Babesiosis Beef cattle Biology and Life Sciences Biotechnology Cattle Causes of Centromere - genetics Chromatin Chromosome 1 Chromosome 3 Chromosomes Chromosomes, Artificial - genetics Complementation Crossovers Deoxyribonucleic acid Dihydrofolate reductase DNA Enzymes Gene conversion Gene Expression Gene Knockout Techniques Genes Genetic aspects Genetic engineering Genomes Genomics Homologous recombination Homology Hypersensitivity Immunity Immunology Infection Infections Infectious diseases Laboratories Ligands Medicine and Health Sciences MMS (Multimedia messaging service) Models, Molecular Nucleosomes Parasites Parasitic diseases Phenotype Phenotypes Protein Conformation Pyrimethamine Rad51 Recombinase - chemistry Rad51 Recombinase - deficiency Rad51 Recombinase - genetics Reductases Research and Analysis Methods Sequence Homology, Nucleic Acid Telomeres Tetrahydrofolate dehydrogenase Varieties Veterinary colleges Veterinary medicine
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