Resistance of Neisseria gonorrhoeae isolates to beta-lactam antibiotics (benzylpenicillin and ceftriaxone) in Russia, 2015-2017

The goal of this work was to study the phenotypic susceptibility and resistance determinants of N. gonorrhoeae isolates to beta-lactam antimicrobials (benzylpenicillin and ceftriaxone). A total of 522 clinical isolates collected in Russia in 2015-2017 were analysed for susceptibility using the agar...

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Veröffentlicht in:	PloS one 2019-07, Vol.14 (7), p.e0220339-e0220339
Hauptverfasser:	Shaskolskiy, Boris, Dementieva, Ekaterina, Kandinov, Ilya, Filippova, Marina, Petrova, Natalia, Plakhova, Xenia, Chestkov, Alexander, Kubanov, Alexey, Deryabin, Dmitry, Gryadunov, Dmitry
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Amides Amino Acid Substitution - genetics Amino acids Anti-Bacterial Agents - pharmacology Anti-Bacterial Agents - therapeutic use Antibiotics Antiinfectives and antibacterials Antimicrobial agents Antimicrobial resistance Benzylpenicillin Beta lactam antibiotics Beta lactamases beta-Lactam Resistance - drug effects beta-Lactam Resistance - genetics beta-Lactamases - genetics Biology and Life Sciences Ceftriaxone Ceftriaxone - pharmacology Ceftriaxone - therapeutic use Cephalosporins Clinical isolates Cosmetology Deoxyribonucleic acid Dilution Distribution DNA DNA chips DNA microarrays DNA Mutational Analysis DNA sequencing Dosage and administration Drug resistance Drug Resistance, Bacterial - drug effects Drug Resistance, Bacterial - genetics Drug therapy Efflux Female Gene mutation Gene sequencing Genes Gonorrhea Gonorrhea - drug therapy Gonorrhea - epidemiology Gonorrhea - microbiology Humans Laboratories Lactams Male Medicine and Health Sciences Microbial drug resistance Microbial Sensitivity Tests Mitochondrial DNA Molecular biology Mutation Neisseria gonorrhoeae - drug effects Neisseria gonorrhoeae - genetics Neisseria gonorrhoeae - isolation & purification Neisseria infections Penicillin Penicillin G Penicillin G - pharmacology Penicillin G - therapeutic use Penicillins People and Places Plasmids Polymorphism, Genetic Prevention Proteins Russia - epidemiology Surveillance Tetracyclines β Lactamase β-Lactam antibiotics
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