Reconstruction of the spatial and temporal dynamics of hepatitis B virus genotype D in the Americas
Hepatitis B virus (HBV) genotype D (HBV/D) is globally widespread, and ten subgenotypes (D1 to D10) showing distinct geographic distributions have been described to date. The evolutionary history of HBV/D and its subgenotypes, for which few complete genome sequences are available, in the Americas is...
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| creator | Spitz, Natália Mello, Francisco C A Moreira, Aline S Gusatti, Carolina S Martins, Regina M B Gomes, Selma A Bello, Gonzalo Araujo, Natalia M |
| description | Hepatitis B virus (HBV) genotype D (HBV/D) is globally widespread, and ten subgenotypes (D1 to D10) showing distinct geographic distributions have been described to date. The evolutionary history of HBV/D and its subgenotypes, for which few complete genome sequences are available, in the Americas is not well understood. The main objective of the current study was to determine the full-length genomic sequences of HBV/D isolates from Brazil and frequency, origin and spread of HBV/D subgenotypes in the Americas. Complete HBV/D genomes isolated from 39 Brazilian patients infected with subgenotypes D1 (n = 1), D2 (n = 10), D3 (n = 27), and D4 (n = 1) were sequenced and analyzed together with reference sequences using the Bayesian coalescent and phylogeographic framework. A search for HBV/D sequences available in GenBank revealed 209 complete and 926 partial genomes from American countries (Argentina, Brazil, Canada, Chile, Colombia, Cuba, Haiti, Martinique, Mexico, USA and Venezuela), with the major circulating subgenotypes identified as D1 (26%), D2 (17%), D3 (36%), D4 (21%), and D7 (1%) within the continent. The detailed evolutionary history of HBV/D in the Americas was investigated by using different evolutionary time scales. Spatiotemporal reconstruction analyses using short-term substitution rates suggested times of the most recent common ancestor for the American HBV/D subgenotypes coincident with mass migratory movements to Americas during the 19th and 20th centuries. In particular, significant linkages between Argentina and Syria (D1), Brazil and Central/Eastern Europe (D2), USA and India (D2), and Brazil and Southern Europe (D3) were estimated, consistent with historical and epidemiological data. |
| doi_str_mv | 10.1371/journal.pone.0220342 |
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The evolutionary history of HBV/D and its subgenotypes, for which few complete genome sequences are available, in the Americas is not well understood. The main objective of the current study was to determine the full-length genomic sequences of HBV/D isolates from Brazil and frequency, origin and spread of HBV/D subgenotypes in the Americas. Complete HBV/D genomes isolated from 39 Brazilian patients infected with subgenotypes D1 (n = 1), D2 (n = 10), D3 (n = 27), and D4 (n = 1) were sequenced and analyzed together with reference sequences using the Bayesian coalescent and phylogeographic framework. A search for HBV/D sequences available in GenBank revealed 209 complete and 926 partial genomes from American countries (Argentina, Brazil, Canada, Chile, Colombia, Cuba, Haiti, Martinique, Mexico, USA and Venezuela), with the major circulating subgenotypes identified as D1 (26%), D2 (17%), D3 (36%), D4 (21%), and D7 (1%) within the continent. The detailed evolutionary history of HBV/D in the Americas was investigated by using different evolutionary time scales. Spatiotemporal reconstruction analyses using short-term substitution rates suggested times of the most recent common ancestor for the American HBV/D subgenotypes coincident with mass migratory movements to Americas during the 19th and 20th centuries. In particular, significant linkages between Argentina and Syria (D1), Brazil and Central/Eastern Europe (D2), USA and India (D2), and Brazil and Southern Europe (D3) were estimated, consistent with historical and epidemiological data.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0220342</identifier><identifier>PMID: 31344111</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Americas - epidemiology ; Analysis ; Antiviral agents ; Bayes Theorem ; Bayesian analysis ; Biology and Life Sciences ; Care and treatment ; Computer and Information Sciences ; Demography ; Deoxyribonucleic acid ; DNA ; DNA, Viral - analysis ; DNA, Viral - genetics ; Earth Sciences ; Ecology and Environmental Sciences ; Epidemiology ; Ethics ; Evolution ; Evolutionary genetics ; Gene sequencing ; Genetic diversity ; Genetics, Population ; Genomes ; Genomics ; Genotype ; Genotype & phenotype ; Genotypes ; Geographical distribution ; Hepatitis ; Hepatitis B ; Hepatitis B - epidemiology ; Hepatitis B - virology ; Hepatitis B virus ; Hepatitis B virus - classification ; Hepatitis B virus - genetics ; Humans ; Immigration ; Laboratories ; Medicine and health sciences ; Mutation ; Noncitizens ; People and places ; Phylogenetics ; Phylogeny ; Phylogeography ; Public health ; Reconstruction ; Research and Analysis Methods ; Retrospective Studies ; Sequence Analysis, DNA ; Virology ; Viruses</subject><ispartof>PloS one, 2019-07, Vol.14 (7), p.e0220342-e0220342</ispartof><rights>COPYRIGHT 2019 Public Library of Science</rights><rights>2019 Spitz et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2019 Spitz et al 2019 Spitz et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-33863885b3cfaa98641ba755be887011b9054966c70fe6c0cffa3a9f393f6aec3</citedby><cites>FETCH-LOGICAL-c692t-33863885b3cfaa98641ba755be887011b9054966c70fe6c0cffa3a9f393f6aec3</cites><orcidid>0000-0001-9037-1304 ; 0000-0002-7979-6376</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6657902/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6657902/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79343,79344</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31344111$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Spitz, Natália</creatorcontrib><creatorcontrib>Mello, Francisco C A</creatorcontrib><creatorcontrib>Moreira, Aline S</creatorcontrib><creatorcontrib>Gusatti, Carolina S</creatorcontrib><creatorcontrib>Martins, Regina M B</creatorcontrib><creatorcontrib>Gomes, Selma A</creatorcontrib><creatorcontrib>Bello, Gonzalo</creatorcontrib><creatorcontrib>Araujo, Natalia M</creatorcontrib><title>Reconstruction of the spatial and temporal dynamics of hepatitis B virus genotype D in the Americas</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Hepatitis B virus (HBV) genotype D (HBV/D) is globally widespread, and ten subgenotypes (D1 to D10) showing distinct geographic distributions have been described to date. The evolutionary history of HBV/D and its subgenotypes, for which few complete genome sequences are available, in the Americas is not well understood. The main objective of the current study was to determine the full-length genomic sequences of HBV/D isolates from Brazil and frequency, origin and spread of HBV/D subgenotypes in the Americas. Complete HBV/D genomes isolated from 39 Brazilian patients infected with subgenotypes D1 (n = 1), D2 (n = 10), D3 (n = 27), and D4 (n = 1) were sequenced and analyzed together with reference sequences using the Bayesian coalescent and phylogeographic framework. A search for HBV/D sequences available in GenBank revealed 209 complete and 926 partial genomes from American countries (Argentina, Brazil, Canada, Chile, Colombia, Cuba, Haiti, Martinique, Mexico, USA and Venezuela), with the major circulating subgenotypes identified as D1 (26%), D2 (17%), D3 (36%), D4 (21%), and D7 (1%) within the continent. The detailed evolutionary history of HBV/D in the Americas was investigated by using different evolutionary time scales. Spatiotemporal reconstruction analyses using short-term substitution rates suggested times of the most recent common ancestor for the American HBV/D subgenotypes coincident with mass migratory movements to Americas during the 19th and 20th centuries. In particular, significant linkages between Argentina and Syria (D1), Brazil and Central/Eastern Europe (D2), USA and India (D2), and Brazil and Southern Europe (D3) were estimated, consistent with historical and epidemiological data.</description><subject>Americas - epidemiology</subject><subject>Analysis</subject><subject>Antiviral agents</subject><subject>Bayes Theorem</subject><subject>Bayesian analysis</subject><subject>Biology and Life Sciences</subject><subject>Care and treatment</subject><subject>Computer and Information Sciences</subject><subject>Demography</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>DNA, Viral - analysis</subject><subject>DNA, Viral - genetics</subject><subject>Earth Sciences</subject><subject>Ecology and Environmental Sciences</subject><subject>Epidemiology</subject><subject>Ethics</subject><subject>Evolution</subject><subject>Evolutionary genetics</subject><subject>Gene sequencing</subject><subject>Genetic diversity</subject><subject>Genetics, Population</subject><subject>Genomes</subject><subject>Genomics</subject><subject>Genotype</subject><subject>Genotype & phenotype</subject><subject>Genotypes</subject><subject>Geographical distribution</subject><subject>Hepatitis</subject><subject>Hepatitis B</subject><subject>Hepatitis B - epidemiology</subject><subject>Hepatitis B - virology</subject><subject>Hepatitis B virus</subject><subject>Hepatitis B virus - classification</subject><subject>Hepatitis B virus - genetics</subject><subject>Humans</subject><subject>Immigration</subject><subject>Laboratories</subject><subject>Medicine and health sciences</subject><subject>Mutation</subject><subject>Noncitizens</subject><subject>People and places</subject><subject>Phylogenetics</subject><subject>Phylogeny</subject><subject>Phylogeography</subject><subject>Public health</subject><subject>Reconstruction</subject><subject>Research and Analysis Methods</subject><subject>Retrospective Studies</subject><subject>Sequence Analysis, DNA</subject><subject>Virology</subject><subject>Viruses</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNk8tu1DAUhiMEoqXwBggiISFYzGDHiRNvkIZyq1SpUrlsrRPHnvEosVPbqZi3x5lJqwnqAnnh23d-27_PSZKXGC0xKfGHrR2cgXbZWyOXKMsQybNHySlmJFvQOHt8ND5Jnnm_RaggFaVPkxOCSZ5jjE8TcS2FNT64QQRtTWpVGjYy9T0EDW0KpkmD7Hrr4qTZGei08CO0kSMRtE8_pbfaDT5dS2PDrpfp51Sbvciqk04L8M-TJwpaL19M_Vny6-uXn-ffF5dX3y7OV5cLQVkWFiRejlRVUROhAFhFc1xDWRS1rKoSYVwzVOSMUlEiJalAQikgwBRhRFGQgpwlrw-6fWs9n_zxPMtonhOaVXkkLg5EY2HLe6c7cDtuQfP9gnVrDi5o0UpeySZvAMpG1WWOs6ZWTNFomwSBAEgWtT5Opw11JxshTYgmzUTnO0Zv-NreckqLkqFR4N0k4OzNIH3gnfZCti0YaYf9vYsywoxF9M0_6MOvm6g1xAdoo2w8V4yifFWwvECM4SpSyweo2BoZPzcmk9JxfRbwfhYQmSD_hDUM3vOLH9f_z179nrNvj9iNhDZsvG2HMQ_9HMwPoHDWeyfVvckY8bEW7tzgYy3wqRZi2KvjD7oPukt-8heGvATX</recordid><startdate>20190725</startdate><enddate>20190725</enddate><creator>Spitz, Natália</creator><creator>Mello, Francisco C A</creator><creator>Moreira, Aline S</creator><creator>Gusatti, Carolina S</creator><creator>Martins, Regina M B</creator><creator>Gomes, Selma A</creator><creator>Bello, Gonzalo</creator><creator>Araujo, Natalia M</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0001-9037-1304</orcidid><orcidid>https://orcid.org/0000-0002-7979-6376</orcidid></search><sort><creationdate>20190725</creationdate><title>Reconstruction of the spatial and temporal dynamics of hepatitis B virus genotype D in the Americas</title><author>Spitz, Natália ; Mello, Francisco C A ; Moreira, Aline S ; Gusatti, Carolina S ; Martins, Regina M B ; Gomes, Selma A ; Bello, Gonzalo ; Araujo, Natalia M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-33863885b3cfaa98641ba755be887011b9054966c70fe6c0cffa3a9f393f6aec3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Americas - 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The evolutionary history of HBV/D and its subgenotypes, for which few complete genome sequences are available, in the Americas is not well understood. The main objective of the current study was to determine the full-length genomic sequences of HBV/D isolates from Brazil and frequency, origin and spread of HBV/D subgenotypes in the Americas. Complete HBV/D genomes isolated from 39 Brazilian patients infected with subgenotypes D1 (n = 1), D2 (n = 10), D3 (n = 27), and D4 (n = 1) were sequenced and analyzed together with reference sequences using the Bayesian coalescent and phylogeographic framework. A search for HBV/D sequences available in GenBank revealed 209 complete and 926 partial genomes from American countries (Argentina, Brazil, Canada, Chile, Colombia, Cuba, Haiti, Martinique, Mexico, USA and Venezuela), with the major circulating subgenotypes identified as D1 (26%), D2 (17%), D3 (36%), D4 (21%), and D7 (1%) within the continent. The detailed evolutionary history of HBV/D in the Americas was investigated by using different evolutionary time scales. Spatiotemporal reconstruction analyses using short-term substitution rates suggested times of the most recent common ancestor for the American HBV/D subgenotypes coincident with mass migratory movements to Americas during the 19th and 20th centuries. In particular, significant linkages between Argentina and Syria (D1), Brazil and Central/Eastern Europe (D2), USA and India (D2), and Brazil and Southern Europe (D3) were estimated, consistent with historical and epidemiological data.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>31344111</pmid><doi>10.1371/journal.pone.0220342</doi><tpages>e0220342</tpages><orcidid>https://orcid.org/0000-0001-9037-1304</orcidid><orcidid>https://orcid.org/0000-0002-7979-6376</orcidid><oa>free_for_read</oa></addata></record> |
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| recordid | cdi_plos_journals_2264436284 |
| source | Directory of Open Access Journals (DOAJ); Public Library of Science (PLoS) Journals Open Access; MEDLINE; PubMed Central; Free Full-Text Journals in Chemistry; EZB Electronic Journals Library |
| subjects | Americas - epidemiology Analysis Antiviral agents Bayes Theorem Bayesian analysis Biology and Life Sciences Care and treatment Computer and Information Sciences Demography Deoxyribonucleic acid DNA DNA, Viral - analysis DNA, Viral - genetics Earth Sciences Ecology and Environmental Sciences Epidemiology Ethics Evolution Evolutionary genetics Gene sequencing Genetic diversity Genetics, Population Genomes Genomics Genotype Genotype & phenotype Genotypes Geographical distribution Hepatitis Hepatitis B Hepatitis B - epidemiology Hepatitis B - virology Hepatitis B virus Hepatitis B virus - classification Hepatitis B virus - genetics Humans Immigration Laboratories Medicine and health sciences Mutation Noncitizens People and places Phylogenetics Phylogeny Phylogeography Public health Reconstruction Research and Analysis Methods Retrospective Studies Sequence Analysis, DNA Virology Viruses |
| title | Reconstruction of the spatial and temporal dynamics of hepatitis B virus genotype D in the Americas |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-01T10%3A50%3A01IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Reconstruction%20of%20the%20spatial%20and%20temporal%20dynamics%20of%20hepatitis%20B%20virus%20genotype%20D%20in%20the%20Americas&rft.jtitle=PloS%20one&rft.au=Spitz,%20Nat%C3%A1lia&rft.date=2019-07-25&rft.volume=14&rft.issue=7&rft.spage=e0220342&rft.epage=e0220342&rft.pages=e0220342-e0220342&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0220342&rft_dat=%3Cgale_plos_%3EA594509918%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2264436284&rft_id=info:pmid/31344111&rft_galeid=A594509918&rft_doaj_id=oai_doaj_org_article_8ed4daa7dfb7412dbf9f6134eac0aa32&rfr_iscdi=true |