The diagnostic performance of PET/CT scans for the detection of para-aortic metastatic lymph nodes in patients with cervical cancer: A meta-analysis
We performed a meta-analysis to evaluate the diagnostic value of positron emission tomography/computed tomography (PET/CT) in the detection of para-aortic lymph node metastasis in cervical cancer. We searched the PubMed, Embase, Web of Science, Cochrane Library, Chinese Biological Medicine (CBM), Ch...
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| Veröffentlicht in: | PloS one 2019-07, Vol.14 (7), p.e0220080-e0220080 |
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| creator | Yu, Weiying Kou, Changgui Bai, Wei Yu, Xiao Duan, Ruixin Zhu, Bo Li, Yuanyuan Hua, Wanqing Ren, Xiaojun Yang, Yanming |
| description | We performed a meta-analysis to evaluate the diagnostic value of positron emission tomography/computed tomography (PET/CT) in the detection of para-aortic lymph node metastasis in cervical cancer.
We searched the PubMed, Embase, Web of Science, Cochrane Library, Chinese Biological Medicine (CBM), Chinese National Knowledge Infrastructure (CNKI), Wanfang and VIP databases in all languages from their inception to September 2018. Stat15.0 software was used to obtain pooled estimates of sensitivity (SEN), specificity (SPE), positive likelihood ratio (PLR), and negative likelihood ratio (NLR) as well as a summary receiver operating characteristic (SROC) curves. Deek's funnel plot was used to assess publication bias. QUADAS-2 was used to evaluate the quality of the studies. The protocol for this meta-analysis is registered in PROSPERO (CRD42019115330).
We obtained 14 studies, and the pooled estimates for sensitivity and specificity of PET/CT were 0.71 (95% confidence interval (CI) = 0.54-0.83) and 0.97 (95% CI = 0.93-0.98), respectively. Pooled PLR and NLR were 21.53 and 0.30, respectively. The diagnostic odds ratio (DOR) was70.59, and the area under the curve (AUC) was 0.95.
PET/CT is an effective and important imaging method for the diagnosis of para-aortic lymph node metastasis in early cervical cancer. |
| doi_str_mv | 10.1371/journal.pone.0220080 |
| format | Article |
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We searched the PubMed, Embase, Web of Science, Cochrane Library, Chinese Biological Medicine (CBM), Chinese National Knowledge Infrastructure (CNKI), Wanfang and VIP databases in all languages from their inception to September 2018. Stat15.0 software was used to obtain pooled estimates of sensitivity (SEN), specificity (SPE), positive likelihood ratio (PLR), and negative likelihood ratio (NLR) as well as a summary receiver operating characteristic (SROC) curves. Deek's funnel plot was used to assess publication bias. QUADAS-2 was used to evaluate the quality of the studies. The protocol for this meta-analysis is registered in PROSPERO (CRD42019115330).
We obtained 14 studies, and the pooled estimates for sensitivity and specificity of PET/CT were 0.71 (95% confidence interval (CI) = 0.54-0.83) and 0.97 (95% CI = 0.93-0.98), respectively. Pooled PLR and NLR were 21.53 and 0.30, respectively. The diagnostic odds ratio (DOR) was70.59, and the area under the curve (AUC) was 0.95.
PET/CT is an effective and important imaging method for the diagnosis of para-aortic lymph node metastasis in early cervical cancer.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0220080</identifier><identifier>PMID: 31318962</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Abdominal aorta ; Aorta ; Biology and Life Sciences ; Biopsy ; Cancer ; Cancer patients ; CAT scans ; Cervical cancer ; Computed tomography ; Confidence intervals ; Diagnosis ; Diagnostic systems ; Emission analysis ; Endometrial cancer ; Evaluation ; Female ; Human papillomavirus ; Humans ; Likelihood ratio ; Lymph nodes ; Lymph Nodes - pathology ; Lymphatic Metastasis ; Medical diagnosis ; Medical examination ; Medical imaging ; Medicine and Health Sciences ; Meta-analysis ; Metastases ; NMR ; Nuclear magnetic resonance ; Odds Ratio ; Physical Sciences ; Positron emission ; Positron emission tomography ; Positron Emission Tomography Computed Tomography - methods ; Professional associations ; Publication Bias ; Research and Analysis Methods ; ROC Curve ; Sensitivity ; Systematic review ; Tomography ; Uterine Cervical Neoplasms - diagnostic imaging ; Uterine Cervical Neoplasms - pathology</subject><ispartof>PloS one, 2019-07, Vol.14 (7), p.e0220080-e0220080</ispartof><rights>COPYRIGHT 2019 Public Library of Science</rights><rights>2019 Yu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2019 Yu et al 2019 Yu et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-9f5fcd70368bf6ad824677d51ee5a3554f06755b2fccb2e38e9e0104a88c74a23</citedby><cites>FETCH-LOGICAL-c692t-9f5fcd70368bf6ad824677d51ee5a3554f06755b2fccb2e38e9e0104a88c74a23</cites><orcidid>0000-0003-0614-7882</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6638976/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6638976/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2101,2927,23865,27923,27924,53790,53792,79471,79472</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31318962$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Shields, Anthony F.</contributor><creatorcontrib>Yu, Weiying</creatorcontrib><creatorcontrib>Kou, Changgui</creatorcontrib><creatorcontrib>Bai, Wei</creatorcontrib><creatorcontrib>Yu, Xiao</creatorcontrib><creatorcontrib>Duan, Ruixin</creatorcontrib><creatorcontrib>Zhu, Bo</creatorcontrib><creatorcontrib>Li, Yuanyuan</creatorcontrib><creatorcontrib>Hua, Wanqing</creatorcontrib><creatorcontrib>Ren, Xiaojun</creatorcontrib><creatorcontrib>Yang, Yanming</creatorcontrib><title>The diagnostic performance of PET/CT scans for the detection of para-aortic metastatic lymph nodes in patients with cervical cancer: A meta-analysis</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>We performed a meta-analysis to evaluate the diagnostic value of positron emission tomography/computed tomography (PET/CT) in the detection of para-aortic lymph node metastasis in cervical cancer.
We searched the PubMed, Embase, Web of Science, Cochrane Library, Chinese Biological Medicine (CBM), Chinese National Knowledge Infrastructure (CNKI), Wanfang and VIP databases in all languages from their inception to September 2018. Stat15.0 software was used to obtain pooled estimates of sensitivity (SEN), specificity (SPE), positive likelihood ratio (PLR), and negative likelihood ratio (NLR) as well as a summary receiver operating characteristic (SROC) curves. Deek's funnel plot was used to assess publication bias. QUADAS-2 was used to evaluate the quality of the studies. The protocol for this meta-analysis is registered in PROSPERO (CRD42019115330).
We obtained 14 studies, and the pooled estimates for sensitivity and specificity of PET/CT were 0.71 (95% confidence interval (CI) = 0.54-0.83) and 0.97 (95% CI = 0.93-0.98), respectively. Pooled PLR and NLR were 21.53 and 0.30, respectively. The diagnostic odds ratio (DOR) was70.59, and the area under the curve (AUC) was 0.95.
PET/CT is an effective and important imaging method for the diagnosis of para-aortic lymph node metastasis in early cervical cancer.</description><subject>Abdominal aorta</subject><subject>Aorta</subject><subject>Biology and Life Sciences</subject><subject>Biopsy</subject><subject>Cancer</subject><subject>Cancer patients</subject><subject>CAT scans</subject><subject>Cervical cancer</subject><subject>Computed tomography</subject><subject>Confidence intervals</subject><subject>Diagnosis</subject><subject>Diagnostic systems</subject><subject>Emission analysis</subject><subject>Endometrial cancer</subject><subject>Evaluation</subject><subject>Female</subject><subject>Human papillomavirus</subject><subject>Humans</subject><subject>Likelihood ratio</subject><subject>Lymph nodes</subject><subject>Lymph Nodes - pathology</subject><subject>Lymphatic Metastasis</subject><subject>Medical diagnosis</subject><subject>Medical examination</subject><subject>Medical imaging</subject><subject>Medicine and Health Sciences</subject><subject>Meta-analysis</subject><subject>Metastases</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Odds Ratio</subject><subject>Physical Sciences</subject><subject>Positron emission</subject><subject>Positron emission tomography</subject><subject>Positron Emission Tomography Computed Tomography - methods</subject><subject>Professional associations</subject><subject>Publication Bias</subject><subject>Research and Analysis Methods</subject><subject>ROC Curve</subject><subject>Sensitivity</subject><subject>Systematic review</subject><subject>Tomography</subject><subject>Uterine Cervical Neoplasms - diagnostic imaging</subject><subject>Uterine Cervical Neoplasms - pathology</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNk9Fu0zAUhiMEYmPwBggsISG4aOfYseNwgTRVAyZNGoLCrXXqnLSekjiz3UHfgwfG2bqpRbtAvrBlf_9_fI59suxlTqc5L_PjS7f2PbTTwfU4pYxRquij7DCvOJtIRvnjnfVB9iyES0oFV1I-zQ54znNVSXaY_ZmvkNQWlr0L0RoyoG-c76A3SFxDvp7Oj2dzEgz0gaQDEkccI5poXT8SA3iYgPOjuMMIIcK4bDfdsCK9qzEQ2ycqWuxjIL9sXBGD_toaaIkZ4_gP5ORGOoGUzybY8Dx70kAb8MV2Psp-fDqdz75Mzi8-n81OzidGVixOqkY0pi4pl2rRSKgVK2RZ1iJHFMCFKBoqSyEWrDFmwZArrJDmtAClTFkA40fZ61vfoXVBbwsaNGOSMqGEGImzW6J2cKkHbzvwG-3A6psN55caxtRb1FLWpqRFpcoaCygAaljUhRFclAsolUpeH7fR1osOa5Pq4aHdM90_6e1KL911cuaqKmUyeLc18O5qjSHqzgaDbQs9uvXNvXMmK06rhL75B304uy21hJSA7RuX4prRVJ-IipdCyWoMO32ASqPGzpr0-xqb9vcE7_cEiYn4Oy5hHYI--_7t_9mLn_vs2x12hdDGVXDtevyKYR8sbkHjXQgem_si51SPzXNXDT02j942T5K92n2ge9Fdt_C_cKsWOA</recordid><startdate>20190718</startdate><enddate>20190718</enddate><creator>Yu, Weiying</creator><creator>Kou, Changgui</creator><creator>Bai, Wei</creator><creator>Yu, Xiao</creator><creator>Duan, Ruixin</creator><creator>Zhu, Bo</creator><creator>Li, Yuanyuan</creator><creator>Hua, Wanqing</creator><creator>Ren, Xiaojun</creator><creator>Yang, Yanming</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0003-0614-7882</orcidid></search><sort><creationdate>20190718</creationdate><title>The diagnostic performance of PET/CT scans for the detection of para-aortic metastatic lymph nodes in patients with cervical cancer: A meta-analysis</title><author>Yu, Weiying ; Kou, Changgui ; Bai, Wei ; Yu, Xiao ; Duan, Ruixin ; Zhu, Bo ; Li, Yuanyuan ; Hua, Wanqing ; Ren, Xiaojun ; Yang, Yanming</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-9f5fcd70368bf6ad824677d51ee5a3554f06755b2fccb2e38e9e0104a88c74a23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Abdominal aorta</topic><topic>Aorta</topic><topic>Biology and Life Sciences</topic><topic>Biopsy</topic><topic>Cancer</topic><topic>Cancer patients</topic><topic>CAT scans</topic><topic>Cervical cancer</topic><topic>Computed tomography</topic><topic>Confidence intervals</topic><topic>Diagnosis</topic><topic>Diagnostic systems</topic><topic>Emission analysis</topic><topic>Endometrial cancer</topic><topic>Evaluation</topic><topic>Female</topic><topic>Human papillomavirus</topic><topic>Humans</topic><topic>Likelihood ratio</topic><topic>Lymph nodes</topic><topic>Lymph Nodes - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yu, Weiying</au><au>Kou, Changgui</au><au>Bai, Wei</au><au>Yu, Xiao</au><au>Duan, Ruixin</au><au>Zhu, Bo</au><au>Li, Yuanyuan</au><au>Hua, Wanqing</au><au>Ren, Xiaojun</au><au>Yang, Yanming</au><au>Shields, Anthony F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The diagnostic performance of PET/CT scans for the detection of para-aortic metastatic lymph nodes in patients with cervical cancer: A meta-analysis</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2019-07-18</date><risdate>2019</risdate><volume>14</volume><issue>7</issue><spage>e0220080</spage><epage>e0220080</epage><pages>e0220080-e0220080</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>We performed a meta-analysis to evaluate the diagnostic value of positron emission tomography/computed tomography (PET/CT) in the detection of para-aortic lymph node metastasis in cervical cancer.
We searched the PubMed, Embase, Web of Science, Cochrane Library, Chinese Biological Medicine (CBM), Chinese National Knowledge Infrastructure (CNKI), Wanfang and VIP databases in all languages from their inception to September 2018. Stat15.0 software was used to obtain pooled estimates of sensitivity (SEN), specificity (SPE), positive likelihood ratio (PLR), and negative likelihood ratio (NLR) as well as a summary receiver operating characteristic (SROC) curves. Deek's funnel plot was used to assess publication bias. QUADAS-2 was used to evaluate the quality of the studies. The protocol for this meta-analysis is registered in PROSPERO (CRD42019115330).
We obtained 14 studies, and the pooled estimates for sensitivity and specificity of PET/CT were 0.71 (95% confidence interval (CI) = 0.54-0.83) and 0.97 (95% CI = 0.93-0.98), respectively. Pooled PLR and NLR were 21.53 and 0.30, respectively. The diagnostic odds ratio (DOR) was70.59, and the area under the curve (AUC) was 0.95.
PET/CT is an effective and important imaging method for the diagnosis of para-aortic lymph node metastasis in early cervical cancer.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>31318962</pmid><doi>10.1371/journal.pone.0220080</doi><orcidid>https://orcid.org/0000-0003-0614-7882</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2019-07, Vol.14 (7), p.e0220080-e0220080 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_2260258552 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS); EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Abdominal aorta Aorta Biology and Life Sciences Biopsy Cancer Cancer patients CAT scans Cervical cancer Computed tomography Confidence intervals Diagnosis Diagnostic systems Emission analysis Endometrial cancer Evaluation Female Human papillomavirus Humans Likelihood ratio Lymph nodes Lymph Nodes - pathology Lymphatic Metastasis Medical diagnosis Medical examination Medical imaging Medicine and Health Sciences Meta-analysis Metastases NMR Nuclear magnetic resonance Odds Ratio Physical Sciences Positron emission Positron emission tomography Positron Emission Tomography Computed Tomography - methods Professional associations Publication Bias Research and Analysis Methods ROC Curve Sensitivity Systematic review Tomography Uterine Cervical Neoplasms - diagnostic imaging Uterine Cervical Neoplasms - pathology |
| title | The diagnostic performance of PET/CT scans for the detection of para-aortic metastatic lymph nodes in patients with cervical cancer: A meta-analysis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-09T03%3A29%3A57IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20diagnostic%20performance%20of%20PET/CT%20scans%20for%20the%20detection%20of%20para-aortic%20metastatic%20lymph%20nodes%20in%20patients%20with%20cervical%20cancer:%20A%20meta-analysis&rft.jtitle=PloS%20one&rft.au=Yu,%20Weiying&rft.date=2019-07-18&rft.volume=14&rft.issue=7&rft.spage=e0220080&rft.epage=e0220080&rft.pages=e0220080-e0220080&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0220080&rft_dat=%3Cgale_plos_%3EA593758696%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2260258552&rft_id=info:pmid/31318962&rft_galeid=A593758696&rft_doaj_id=oai_doaj_org_article_66dc704987de4a4aadabd4c5357ba788&rfr_iscdi=true |