Combination of left ventricular reverse remodeling and brain natriuretic peptide level at one year after cardiac resynchronization therapy predicts long-term clinical outcome
The aim of this study was to investigate the predictors of long-term clinical outcome of heart failure (HF) patients who survived first year after initiation of cardiac resynchronization therapy (CRT). This was a single-center observational cohort study of CRT patients implanted because of symptomat...
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| Veröffentlicht in: | PloS one 2019-07, Vol.14 (7), p.e0219966-e0219966 |
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| creator | Roubicek, Tomas Stros, Jan Kucera, Pavel Nedbal, Pavel Cerny, Jan Polasek, Rostislav Wichterle, Dan |
| description | The aim of this study was to investigate the predictors of long-term clinical outcome of heart failure (HF) patients who survived first year after initiation of cardiac resynchronization therapy (CRT).
This was a single-center observational cohort study of CRT patients implanted because of symptomatic HF with reduced ejection fraction between 2005 and 2013. Left ventricle (LV) diameters and ejection fraction, New York Heart Association (NYHA) class, and level of N-terminal fragment of pro-brain natriuretic peptide (NT-proBNP) were assessed at baseline and 12 months after CRT implantation. Their predictive power for long-term HF hospitalization and mortality, and cardiac and all-cause mortality was investigated.
A total of 315 patients with left bundle branch block or intraventricular conduction delay who survived >1 year after CRT implantation were analyzed in the current study. During a follow-up period of 4.8±2.1 years from CRT implantation, 35.2% patients died from cardiac (19.3%) or non-cardiac (15.9%) causes. Post-CRT LV ejection fraction and LV end-systolic diameter (either 12-month value or the change from baseline) were equally predictive for clinical events. For NT-proBNP, however, the 12-month level was a stronger predictor than the change from baseline. Both reverse LV remodeling and 12-month level of NT-proBNP were independent and comparable predictors of CRT-related clinical outcome, while NT-proBNP response had the strongest association with all-cause mortality. When post-CRT relative change of LV end-systolic diameter and 12-month level of NT-proBNP (dichotomized at -12.3% and 1230 ng/L, respectively) were combined, subgroups of very-high and very-low risk patients were identified.
The level of NT-proBNP and reverse LV remodeling at one year after CRT are independent and complementary predictors of future clinical events. Their combination may help to improve the risk stratification of CRT patients. |
| doi_str_mv | 10.1371/journal.pone.0219966 |
| format | Article |
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This was a single-center observational cohort study of CRT patients implanted because of symptomatic HF with reduced ejection fraction between 2005 and 2013. Left ventricle (LV) diameters and ejection fraction, New York Heart Association (NYHA) class, and level of N-terminal fragment of pro-brain natriuretic peptide (NT-proBNP) were assessed at baseline and 12 months after CRT implantation. Their predictive power for long-term HF hospitalization and mortality, and cardiac and all-cause mortality was investigated.
A total of 315 patients with left bundle branch block or intraventricular conduction delay who survived >1 year after CRT implantation were analyzed in the current study. During a follow-up period of 4.8±2.1 years from CRT implantation, 35.2% patients died from cardiac (19.3%) or non-cardiac (15.9%) causes. Post-CRT LV ejection fraction and LV end-systolic diameter (either 12-month value or the change from baseline) were equally predictive for clinical events. For NT-proBNP, however, the 12-month level was a stronger predictor than the change from baseline. Both reverse LV remodeling and 12-month level of NT-proBNP were independent and comparable predictors of CRT-related clinical outcome, while NT-proBNP response had the strongest association with all-cause mortality. When post-CRT relative change of LV end-systolic diameter and 12-month level of NT-proBNP (dichotomized at -12.3% and 1230 ng/L, respectively) were combined, subgroups of very-high and very-low risk patients were identified.
The level of NT-proBNP and reverse LV remodeling at one year after CRT are independent and complementary predictors of future clinical events. Their combination may help to improve the risk stratification of CRT patients.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0219966</identifier><identifier>PMID: 31314790</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Aged ; Analysis ; Beta blockers ; Biology and Life Sciences ; Biomarkers ; Brain ; Brain natriuretic peptide ; Cardiac arrhythmia ; Cardiac patients ; Cardiac resynchronization therapy ; Cardiac Resynchronization Therapy - adverse effects ; Cardiac Resynchronization Therapy - methods ; Cardiology ; Care and treatment ; Clinical outcomes ; Congestive heart failure ; Engineering and Technology ; Female ; Heart ; Heart failure ; Heart Failure - metabolism ; Heart Failure - mortality ; Heart Failure - pathology ; Heart Failure - therapy ; Heart Function Tests ; Hospitals ; Humans ; Implantation ; Laboratories ; Male ; Medical research ; Medicine and Health Sciences ; Middle Aged ; Mortality ; Natriuretic Peptide, Brain - metabolism ; Natriuretic peptides ; Peptides ; Postoperative Period ; Prognosis ; ROC Curve ; Studies ; Subgroups ; Therapy ; Time Factors ; Treatment Outcome ; Ventricle ; Ventricular Remodeling</subject><ispartof>PloS one, 2019-07, Vol.14 (7), p.e0219966-e0219966</ispartof><rights>COPYRIGHT 2019 Public Library of Science</rights><rights>2019 Roubicek et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2019 Roubicek et al 2019 Roubicek et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-557c813a0e31334dd9f6d8600b9d5e06c93a31610fbf47071f4058f4da3ea5b83</citedby><cites>FETCH-LOGICAL-c692t-557c813a0e31334dd9f6d8600b9d5e06c93a31610fbf47071f4058f4da3ea5b83</cites><orcidid>0000-0001-8480-5110</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6636764/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6636764/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31314790$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Lionetti, Vincenzo</contributor><creatorcontrib>Roubicek, Tomas</creatorcontrib><creatorcontrib>Stros, Jan</creatorcontrib><creatorcontrib>Kucera, Pavel</creatorcontrib><creatorcontrib>Nedbal, Pavel</creatorcontrib><creatorcontrib>Cerny, Jan</creatorcontrib><creatorcontrib>Polasek, Rostislav</creatorcontrib><creatorcontrib>Wichterle, Dan</creatorcontrib><title>Combination of left ventricular reverse remodeling and brain natriuretic peptide level at one year after cardiac resynchronization therapy predicts long-term clinical outcome</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>The aim of this study was to investigate the predictors of long-term clinical outcome of heart failure (HF) patients who survived first year after initiation of cardiac resynchronization therapy (CRT).
This was a single-center observational cohort study of CRT patients implanted because of symptomatic HF with reduced ejection fraction between 2005 and 2013. Left ventricle (LV) diameters and ejection fraction, New York Heart Association (NYHA) class, and level of N-terminal fragment of pro-brain natriuretic peptide (NT-proBNP) were assessed at baseline and 12 months after CRT implantation. Their predictive power for long-term HF hospitalization and mortality, and cardiac and all-cause mortality was investigated.
A total of 315 patients with left bundle branch block or intraventricular conduction delay who survived >1 year after CRT implantation were analyzed in the current study. During a follow-up period of 4.8±2.1 years from CRT implantation, 35.2% patients died from cardiac (19.3%) or non-cardiac (15.9%) causes. Post-CRT LV ejection fraction and LV end-systolic diameter (either 12-month value or the change from baseline) were equally predictive for clinical events. For NT-proBNP, however, the 12-month level was a stronger predictor than the change from baseline. Both reverse LV remodeling and 12-month level of NT-proBNP were independent and comparable predictors of CRT-related clinical outcome, while NT-proBNP response had the strongest association with all-cause mortality. When post-CRT relative change of LV end-systolic diameter and 12-month level of NT-proBNP (dichotomized at -12.3% and 1230 ng/L, respectively) were combined, subgroups of very-high and very-low risk patients were identified.
The level of NT-proBNP and reverse LV remodeling at one year after CRT are independent and complementary predictors of future clinical events. Their combination may help to improve the risk stratification of CRT patients.</description><subject>Aged</subject><subject>Analysis</subject><subject>Beta blockers</subject><subject>Biology and Life Sciences</subject><subject>Biomarkers</subject><subject>Brain</subject><subject>Brain natriuretic peptide</subject><subject>Cardiac arrhythmia</subject><subject>Cardiac patients</subject><subject>Cardiac resynchronization therapy</subject><subject>Cardiac Resynchronization Therapy - adverse effects</subject><subject>Cardiac Resynchronization Therapy - methods</subject><subject>Cardiology</subject><subject>Care and treatment</subject><subject>Clinical outcomes</subject><subject>Congestive heart failure</subject><subject>Engineering and Technology</subject><subject>Female</subject><subject>Heart</subject><subject>Heart failure</subject><subject>Heart Failure - metabolism</subject><subject>Heart Failure - mortality</subject><subject>Heart Failure - pathology</subject><subject>Heart Failure - therapy</subject><subject>Heart Function Tests</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Implantation</subject><subject>Laboratories</subject><subject>Male</subject><subject>Medical research</subject><subject>Medicine and Health Sciences</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Natriuretic Peptide, Brain - metabolism</subject><subject>Natriuretic peptides</subject><subject>Peptides</subject><subject>Postoperative Period</subject><subject>Prognosis</subject><subject>ROC Curve</subject><subject>Studies</subject><subject>Subgroups</subject><subject>Therapy</subject><subject>Time Factors</subject><subject>Treatment Outcome</subject><subject>Ventricle</subject><subject>Ventricular Remodeling</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNk12L1DAUhoso7rr6D0QDgujFjEnTps2NsCx-DCws-HUb0uR0JkOadJN0cPxR_kYzzuyyI3shvUhJn_c9OW96iuI5wXNCG_Ju7afgpJ2P3sEcl4Rzxh4Up4TTcsZKTB_eeT8pnsS4xrimLWOPixNKKKkajk-L3xd-6IyTyXiHfI8s9AltwKVg1GRlQAE2ECLkdfAarHFLJJ1GXZDGoawLZgqQjEIjjMloyA4bsEgmlM-FtpAtZJ8gICWDNlJlo7h1ahW8M7_2ZdMKghy3aAygjUoRWe-Ws6wZkMoFjZIW-SkpP8DT4lEvbYRnh_Ws-P7xw7eLz7PLq0-Li_PLmWK8TLO6blRLqMSQO6WV1rxnumUYd1zXgJniVFLCCO67vmpwQ_oK121faUlB1l1Lz4qXe9_R-igOUUdRljWnvG1omYnFntBersUYzCDDVnhpxN8NH5ZChpyLBQEVyKbsurohVUVIybXqWknqnnfQceiy1_tDtakbQKtd_NIemR5_cWYlln4jGKOsYVU2eHMwCP56gpjEYKICa6UDP-3PzTFnZZ3RV_-g93d3oJYyN2Bc73NdtTMV5xlitGwwydT8Hio_Ggaj8v33Ju8fCd4eCTKT4GdayilGsfj65f_Zqx_H7Os77AqkTavo7bT7veIxWO1BFXyMAfrbkAkWu7G6SUPsxkocxirLXty9oFvRzRzRPy2EIfk</recordid><startdate>20190717</startdate><enddate>20190717</enddate><creator>Roubicek, Tomas</creator><creator>Stros, Jan</creator><creator>Kucera, Pavel</creator><creator>Nedbal, Pavel</creator><creator>Cerny, Jan</creator><creator>Polasek, Rostislav</creator><creator>Wichterle, Dan</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0001-8480-5110</orcidid></search><sort><creationdate>20190717</creationdate><title>Combination of left ventricular reverse remodeling and brain natriuretic peptide level at one year after cardiac resynchronization therapy predicts long-term clinical outcome</title><author>Roubicek, Tomas ; Stros, Jan ; Kucera, Pavel ; Nedbal, Pavel ; Cerny, Jan ; Polasek, Rostislav ; Wichterle, Dan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-557c813a0e31334dd9f6d8600b9d5e06c93a31610fbf47071f4058f4da3ea5b83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Aged</topic><topic>Analysis</topic><topic>Beta blockers</topic><topic>Biology and Life Sciences</topic><topic>Biomarkers</topic><topic>Brain</topic><topic>Brain natriuretic peptide</topic><topic>Cardiac arrhythmia</topic><topic>Cardiac patients</topic><topic>Cardiac resynchronization therapy</topic><topic>Cardiac Resynchronization Therapy - adverse effects</topic><topic>Cardiac Resynchronization Therapy - methods</topic><topic>Cardiology</topic><topic>Care and treatment</topic><topic>Clinical outcomes</topic><topic>Congestive heart failure</topic><topic>Engineering and Technology</topic><topic>Female</topic><topic>Heart</topic><topic>Heart failure</topic><topic>Heart Failure - metabolism</topic><topic>Heart Failure - mortality</topic><topic>Heart Failure - pathology</topic><topic>Heart Failure - therapy</topic><topic>Heart Function Tests</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Implantation</topic><topic>Laboratories</topic><topic>Male</topic><topic>Medical research</topic><topic>Medicine and Health Sciences</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Natriuretic Peptide, Brain - metabolism</topic><topic>Natriuretic peptides</topic><topic>Peptides</topic><topic>Postoperative Period</topic><topic>Prognosis</topic><topic>ROC Curve</topic><topic>Studies</topic><topic>Subgroups</topic><topic>Therapy</topic><topic>Time Factors</topic><topic>Treatment Outcome</topic><topic>Ventricle</topic><topic>Ventricular Remodeling</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Roubicek, Tomas</creatorcontrib><creatorcontrib>Stros, Jan</creatorcontrib><creatorcontrib>Kucera, Pavel</creatorcontrib><creatorcontrib>Nedbal, Pavel</creatorcontrib><creatorcontrib>Cerny, Jan</creatorcontrib><creatorcontrib>Polasek, Rostislav</creatorcontrib><creatorcontrib>Wichterle, Dan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Roubicek, Tomas</au><au>Stros, Jan</au><au>Kucera, Pavel</au><au>Nedbal, Pavel</au><au>Cerny, Jan</au><au>Polasek, Rostislav</au><au>Wichterle, Dan</au><au>Lionetti, Vincenzo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Combination of left ventricular reverse remodeling and brain natriuretic peptide level at one year after cardiac resynchronization therapy predicts long-term clinical outcome</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2019-07-17</date><risdate>2019</risdate><volume>14</volume><issue>7</issue><spage>e0219966</spage><epage>e0219966</epage><pages>e0219966-e0219966</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>The aim of this study was to investigate the predictors of long-term clinical outcome of heart failure (HF) patients who survived first year after initiation of cardiac resynchronization therapy (CRT).
This was a single-center observational cohort study of CRT patients implanted because of symptomatic HF with reduced ejection fraction between 2005 and 2013. Left ventricle (LV) diameters and ejection fraction, New York Heart Association (NYHA) class, and level of N-terminal fragment of pro-brain natriuretic peptide (NT-proBNP) were assessed at baseline and 12 months after CRT implantation. Their predictive power for long-term HF hospitalization and mortality, and cardiac and all-cause mortality was investigated.
A total of 315 patients with left bundle branch block or intraventricular conduction delay who survived >1 year after CRT implantation were analyzed in the current study. During a follow-up period of 4.8±2.1 years from CRT implantation, 35.2% patients died from cardiac (19.3%) or non-cardiac (15.9%) causes. Post-CRT LV ejection fraction and LV end-systolic diameter (either 12-month value or the change from baseline) were equally predictive for clinical events. For NT-proBNP, however, the 12-month level was a stronger predictor than the change from baseline. Both reverse LV remodeling and 12-month level of NT-proBNP were independent and comparable predictors of CRT-related clinical outcome, while NT-proBNP response had the strongest association with all-cause mortality. When post-CRT relative change of LV end-systolic diameter and 12-month level of NT-proBNP (dichotomized at -12.3% and 1230 ng/L, respectively) were combined, subgroups of very-high and very-low risk patients were identified.
The level of NT-proBNP and reverse LV remodeling at one year after CRT are independent and complementary predictors of future clinical events. Their combination may help to improve the risk stratification of CRT patients.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>31314790</pmid><doi>10.1371/journal.pone.0219966</doi><tpages>e0219966</tpages><orcidid>https://orcid.org/0000-0001-8480-5110</orcidid><oa>free_for_read</oa></addata></record> |
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| language | eng |
| recordid | cdi_plos_journals_2259398732 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Aged Analysis Beta blockers Biology and Life Sciences Biomarkers Brain Brain natriuretic peptide Cardiac arrhythmia Cardiac patients Cardiac resynchronization therapy Cardiac Resynchronization Therapy - adverse effects Cardiac Resynchronization Therapy - methods Cardiology Care and treatment Clinical outcomes Congestive heart failure Engineering and Technology Female Heart Heart failure Heart Failure - metabolism Heart Failure - mortality Heart Failure - pathology Heart Failure - therapy Heart Function Tests Hospitals Humans Implantation Laboratories Male Medical research Medicine and Health Sciences Middle Aged Mortality Natriuretic Peptide, Brain - metabolism Natriuretic peptides Peptides Postoperative Period Prognosis ROC Curve Studies Subgroups Therapy Time Factors Treatment Outcome Ventricle Ventricular Remodeling |
| title | Combination of left ventricular reverse remodeling and brain natriuretic peptide level at one year after cardiac resynchronization therapy predicts long-term clinical outcome |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-23T01%3A21%3A08IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Combination%20of%20left%20ventricular%20reverse%20remodeling%20and%20brain%20natriuretic%20peptide%20level%20at%20one%20year%20after%20cardiac%20resynchronization%20therapy%20predicts%20long-term%20clinical%20outcome&rft.jtitle=PloS%20one&rft.au=Roubicek,%20Tomas&rft.date=2019-07-17&rft.volume=14&rft.issue=7&rft.spage=e0219966&rft.epage=e0219966&rft.pages=e0219966-e0219966&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0219966&rft_dat=%3Cgale_plos_%3EA593632701%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2259398732&rft_id=info:pmid/31314790&rft_galeid=A593632701&rft_doaj_id=oai_doaj_org_article_e4ea72bb571441129dcb8a15f9beb9eb&rfr_iscdi=true |