Altered temporal dynamics of brain activity in patients with generalized tonic-clonic seizures
Generalized seizures engage bilateral networks from their onset at a low temporal scale. Previous studies findings have demonstrated focal/local brain activity abnormalities in the patients with generalized tonic-clonic seizures (GTCS). Resting state functional magnetic resonance imaging (fMRI) allo...
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| creator | Liu, Honglei Li, Wenling Zhao, Mingjuan Wu, Jie Wu, Jing Yang, Jiankai Jiao, Baohua |
| description | Generalized seizures engage bilateral networks from their onset at a low temporal scale. Previous studies findings have demonstrated focal/local brain activity abnormalities in the patients with generalized tonic-clonic seizures (GTCS). Resting state functional magnetic resonance imaging (fMRI) allows the detection of aberrant spontaneous brain activity in GTCS. Little is known, however, about alterations of dynamics (temporal variability) of spontaneous brain activity. It also remains unclear whether temporal variability of spontaneous brain activity is associated with disease severity. To address these questions, the current study assessed patients with GTCS (n = 35), and age- and sex-matched healthy controls (HCs, n = 33) who underwent resting state fMRI. We first assessed the dynamics of spontaneous brain activity using dynamic amplitude of low-frequency fluctuation (dALFF). Furthermore, the temporal variability of brain activity was quantified as the variance of dALFF across sliding window. Compared to HCs, patients with GTCS showed hyper-temporal variability of dALFF in parts of the default mode network, whereas they showed hypo-temporal variability in the somatomotor cortex. Furthermore, dynamic ALFF in the subgenual anterior cingulate cortex was positively correlated with duration of disease, indicating that disease severity is associated with excessive variability. These results suggest both an excessive variability and excessive stability in patients with GTCS. Overall, the current findings from brain activity dynamics contribute to our understanding of the pathophysiological mechanisms of generalized seizure. |
| doi_str_mv | 10.1371/journal.pone.0219904 |
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Previous studies findings have demonstrated focal/local brain activity abnormalities in the patients with generalized tonic-clonic seizures (GTCS). Resting state functional magnetic resonance imaging (fMRI) allows the detection of aberrant spontaneous brain activity in GTCS. Little is known, however, about alterations of dynamics (temporal variability) of spontaneous brain activity. It also remains unclear whether temporal variability of spontaneous brain activity is associated with disease severity. To address these questions, the current study assessed patients with GTCS (n = 35), and age- and sex-matched healthy controls (HCs, n = 33) who underwent resting state fMRI. We first assessed the dynamics of spontaneous brain activity using dynamic amplitude of low-frequency fluctuation (dALFF). Furthermore, the temporal variability of brain activity was quantified as the variance of dALFF across sliding window. Compared to HCs, patients with GTCS showed hyper-temporal variability of dALFF in parts of the default mode network, whereas they showed hypo-temporal variability in the somatomotor cortex. Furthermore, dynamic ALFF in the subgenual anterior cingulate cortex was positively correlated with duration of disease, indicating that disease severity is associated with excessive variability. These results suggest both an excessive variability and excessive stability in patients with GTCS. Overall, the current findings from brain activity dynamics contribute to our understanding of the pathophysiological mechanisms of generalized seizure.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0219904</identifier><identifier>PMID: 31314786</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Abnormalities ; Adult ; Anticonvulsants - pharmacology ; Anticonvulsants - therapeutic use ; Biology and Life Sciences ; Brain ; Brain - diagnostic imaging ; Brain - physiopathology ; Brain Mapping ; Brain research ; Brain waves ; Computer and Information Sciences ; Connectivity ; Consciousness ; Convulsions & seizures ; Cortex (cingulate) ; Cortex (temporal) ; Diagnosis ; Diagnostic imaging ; Dynamic tests ; Dynamics ; Electroencephalography ; Epilepsy ; Female ; Functional magnetic resonance imaging ; Hospitals ; Humans ; Lamotrigine ; Magnetic resonance ; Magnetic resonance imaging ; Magnetic Resonance Imaging - methods ; Male ; Measurement ; Medical research ; Medicine and Health Sciences ; Middle Aged ; Neuroimaging ; Neurosurgery ; NMR ; Nuclear magnetic resonance ; Physiological aspects ; Research and Analysis Methods ; Seizures ; Seizures (Medicine) ; Seizures - diagnostic imaging ; Seizures - drug therapy ; Seizures - physiopathology ; Somatotropin ; Temporal lobe epilepsy ; Temporal variability ; Tonic-clonic epilepsy ; Treatment Outcome ; Variability ; Young Adult</subject><ispartof>PloS one, 2019-07, Vol.14 (7), p.e0219904-e0219904</ispartof><rights>COPYRIGHT 2019 Public Library of Science</rights><rights>2019 Liu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2019 Liu et al 2019 Liu et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-7a151ce2aad673fcdcec210d680346e9c6e67b0c98b48f958f0f4e1146ce68b03</citedby><cites>FETCH-LOGICAL-c692t-7a151ce2aad673fcdcec210d680346e9c6e67b0c98b48f958f0f4e1146ce68b03</cites><orcidid>0000-0002-8563-1623</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6636756/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6636756/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,861,882,2096,2915,23847,27905,27906,53772,53774,79349,79350</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31314786$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Charpier, Stéphane</contributor><creatorcontrib>Liu, Honglei</creatorcontrib><creatorcontrib>Li, Wenling</creatorcontrib><creatorcontrib>Zhao, Mingjuan</creatorcontrib><creatorcontrib>Wu, Jie</creatorcontrib><creatorcontrib>Wu, Jing</creatorcontrib><creatorcontrib>Yang, Jiankai</creatorcontrib><creatorcontrib>Jiao, Baohua</creatorcontrib><title>Altered temporal dynamics of brain activity in patients with generalized tonic-clonic seizures</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Generalized seizures engage bilateral networks from their onset at a low temporal scale. Previous studies findings have demonstrated focal/local brain activity abnormalities in the patients with generalized tonic-clonic seizures (GTCS). Resting state functional magnetic resonance imaging (fMRI) allows the detection of aberrant spontaneous brain activity in GTCS. Little is known, however, about alterations of dynamics (temporal variability) of spontaneous brain activity. It also remains unclear whether temporal variability of spontaneous brain activity is associated with disease severity. To address these questions, the current study assessed patients with GTCS (n = 35), and age- and sex-matched healthy controls (HCs, n = 33) who underwent resting state fMRI. We first assessed the dynamics of spontaneous brain activity using dynamic amplitude of low-frequency fluctuation (dALFF). Furthermore, the temporal variability of brain activity was quantified as the variance of dALFF across sliding window. Compared to HCs, patients with GTCS showed hyper-temporal variability of dALFF in parts of the default mode network, whereas they showed hypo-temporal variability in the somatomotor cortex. Furthermore, dynamic ALFF in the subgenual anterior cingulate cortex was positively correlated with duration of disease, indicating that disease severity is associated with excessive variability. These results suggest both an excessive variability and excessive stability in patients with GTCS. Overall, the current findings from brain activity dynamics contribute to our understanding of the pathophysiological mechanisms of generalized seizure.</description><subject>Abnormalities</subject><subject>Adult</subject><subject>Anticonvulsants - pharmacology</subject><subject>Anticonvulsants - therapeutic use</subject><subject>Biology and Life Sciences</subject><subject>Brain</subject><subject>Brain - diagnostic imaging</subject><subject>Brain - physiopathology</subject><subject>Brain Mapping</subject><subject>Brain research</subject><subject>Brain waves</subject><subject>Computer and Information Sciences</subject><subject>Connectivity</subject><subject>Consciousness</subject><subject>Convulsions & seizures</subject><subject>Cortex (cingulate)</subject><subject>Cortex (temporal)</subject><subject>Diagnosis</subject><subject>Diagnostic imaging</subject><subject>Dynamic tests</subject><subject>Dynamics</subject><subject>Electroencephalography</subject><subject>Epilepsy</subject><subject>Female</subject><subject>Functional magnetic resonance imaging</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Lamotrigine</subject><subject>Magnetic resonance</subject><subject>Magnetic resonance imaging</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Male</subject><subject>Measurement</subject><subject>Medical research</subject><subject>Medicine and Health Sciences</subject><subject>Middle Aged</subject><subject>Neuroimaging</subject><subject>Neurosurgery</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Physiological aspects</subject><subject>Research and Analysis Methods</subject><subject>Seizures</subject><subject>Seizures (Medicine)</subject><subject>Seizures - diagnostic imaging</subject><subject>Seizures - drug therapy</subject><subject>Seizures - physiopathology</subject><subject>Somatotropin</subject><subject>Temporal lobe epilepsy</subject><subject>Temporal variability</subject><subject>Tonic-clonic epilepsy</subject><subject>Treatment Outcome</subject><subject>Variability</subject><subject>Young Adult</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNk12L1DAUhoso7jr6D0QLgujFjPlo0-ZGGBY_BhYW_Lo0pOnpTJZMMpukq7O_3tTpLlPZC8lFQvK8b845ycmy5xgtMK3wu0vXeyvNYucsLBDBnKPiQXaKOSVzRhB9eLQ-yZ6EcIlQSWvGHmcnFFNcVDU7zX4uTQQPbR5hu3NemrzdW7nVKuSuyxsvtc2livpax32e1jsZNdgY8l86bvI1WEgafTMYOKvVXJlhygPom95DeJo96qQJ8GycZ9n3jx--nX2en198Wp0tz-eKcRLnlcQlVkCkbFlFO9UqUASjltWIFgy4YsCqBileN0Xd8bLuUFcAxgVTwOoG0Vn28uC7My6IsTRBEFJyWrIymc6y1YFonbwUO6-30u-Fk1r83XB-LaSPWhkQiHUNIU0LUOKCA3BeVkUFsiC0YxRI8no_3tY3W0jB2piqMDGdnli9EWt3LRijrCpZMngzGnh31UOIYquDAmOkBdcf4uaYIFYm9NU_6P3ZjdRapgS07Vy6Vw2mYpkgRkmFB6_FPVQaLaQXT_-o02l_Ing7ESQmwu-4ln0IYvX1y_-zFz-m7OsjdgPSxE1wpo_a2TAFiwOovAvBQ3dXZIzE0Aa31RBDG4ixDZLsxfED3Ylu_z39A_C7A4o</recordid><startdate>20190717</startdate><enddate>20190717</enddate><creator>Liu, Honglei</creator><creator>Li, Wenling</creator><creator>Zhao, Mingjuan</creator><creator>Wu, Jie</creator><creator>Wu, Jing</creator><creator>Yang, Jiankai</creator><creator>Jiao, Baohua</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-8563-1623</orcidid></search><sort><creationdate>20190717</creationdate><title>Altered temporal dynamics of brain activity in patients with generalized tonic-clonic seizures</title><author>Liu, Honglei ; Li, Wenling ; Zhao, Mingjuan ; Wu, Jie ; Wu, Jing ; Yang, Jiankai ; Jiao, Baohua</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-7a151ce2aad673fcdcec210d680346e9c6e67b0c98b48f958f0f4e1146ce68b03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Abnormalities</topic><topic>Adult</topic><topic>Anticonvulsants - pharmacology</topic><topic>Anticonvulsants - therapeutic use</topic><topic>Biology and Life Sciences</topic><topic>Brain</topic><topic>Brain - diagnostic imaging</topic><topic>Brain - physiopathology</topic><topic>Brain Mapping</topic><topic>Brain research</topic><topic>Brain waves</topic><topic>Computer and Information Sciences</topic><topic>Connectivity</topic><topic>Consciousness</topic><topic>Convulsions & seizures</topic><topic>Cortex (cingulate)</topic><topic>Cortex (temporal)</topic><topic>Diagnosis</topic><topic>Diagnostic imaging</topic><topic>Dynamic tests</topic><topic>Dynamics</topic><topic>Electroencephalography</topic><topic>Epilepsy</topic><topic>Female</topic><topic>Functional magnetic resonance imaging</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Lamotrigine</topic><topic>Magnetic resonance</topic><topic>Magnetic resonance imaging</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Male</topic><topic>Measurement</topic><topic>Medical research</topic><topic>Medicine and Health Sciences</topic><topic>Middle Aged</topic><topic>Neuroimaging</topic><topic>Neurosurgery</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Physiological aspects</topic><topic>Research and Analysis Methods</topic><topic>Seizures</topic><topic>Seizures (Medicine)</topic><topic>Seizures - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Honglei</au><au>Li, Wenling</au><au>Zhao, Mingjuan</au><au>Wu, Jie</au><au>Wu, Jing</au><au>Yang, Jiankai</au><au>Jiao, Baohua</au><au>Charpier, Stéphane</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Altered temporal dynamics of brain activity in patients with generalized tonic-clonic seizures</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2019-07-17</date><risdate>2019</risdate><volume>14</volume><issue>7</issue><spage>e0219904</spage><epage>e0219904</epage><pages>e0219904-e0219904</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Generalized seizures engage bilateral networks from their onset at a low temporal scale. Previous studies findings have demonstrated focal/local brain activity abnormalities in the patients with generalized tonic-clonic seizures (GTCS). Resting state functional magnetic resonance imaging (fMRI) allows the detection of aberrant spontaneous brain activity in GTCS. Little is known, however, about alterations of dynamics (temporal variability) of spontaneous brain activity. It also remains unclear whether temporal variability of spontaneous brain activity is associated with disease severity. To address these questions, the current study assessed patients with GTCS (n = 35), and age- and sex-matched healthy controls (HCs, n = 33) who underwent resting state fMRI. We first assessed the dynamics of spontaneous brain activity using dynamic amplitude of low-frequency fluctuation (dALFF). Furthermore, the temporal variability of brain activity was quantified as the variance of dALFF across sliding window. Compared to HCs, patients with GTCS showed hyper-temporal variability of dALFF in parts of the default mode network, whereas they showed hypo-temporal variability in the somatomotor cortex. Furthermore, dynamic ALFF in the subgenual anterior cingulate cortex was positively correlated with duration of disease, indicating that disease severity is associated with excessive variability. These results suggest both an excessive variability and excessive stability in patients with GTCS. Overall, the current findings from brain activity dynamics contribute to our understanding of the pathophysiological mechanisms of generalized seizure.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>31314786</pmid><doi>10.1371/journal.pone.0219904</doi><tpages>e0219904</tpages><orcidid>https://orcid.org/0000-0002-8563-1623</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Public Library of Science (PLoS); PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Abnormalities Adult Anticonvulsants - pharmacology Anticonvulsants - therapeutic use Biology and Life Sciences Brain Brain - diagnostic imaging Brain - physiopathology Brain Mapping Brain research Brain waves Computer and Information Sciences Connectivity Consciousness Convulsions & seizures Cortex (cingulate) Cortex (temporal) Diagnosis Diagnostic imaging Dynamic tests Dynamics Electroencephalography Epilepsy Female Functional magnetic resonance imaging Hospitals Humans Lamotrigine Magnetic resonance Magnetic resonance imaging Magnetic Resonance Imaging - methods Male Measurement Medical research Medicine and Health Sciences Middle Aged Neuroimaging Neurosurgery NMR Nuclear magnetic resonance Physiological aspects Research and Analysis Methods Seizures Seizures (Medicine) Seizures - diagnostic imaging Seizures - drug therapy Seizures - physiopathology Somatotropin Temporal lobe epilepsy Temporal variability Tonic-clonic epilepsy Treatment Outcome Variability Young Adult |
| title | Altered temporal dynamics of brain activity in patients with generalized tonic-clonic seizures |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-20T20%3A03%3A21IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Altered%20temporal%20dynamics%20of%20brain%20activity%20in%20patients%20with%20generalized%20tonic-clonic%20seizures&rft.jtitle=PloS%20one&rft.au=Liu,%20Honglei&rft.date=2019-07-17&rft.volume=14&rft.issue=7&rft.spage=e0219904&rft.epage=e0219904&rft.pages=e0219904-e0219904&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0219904&rft_dat=%3Cgale_plos_%3EA593632715%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2259356567&rft_id=info:pmid/31314786&rft_galeid=A593632715&rft_doaj_id=oai_doaj_org_article_06fb22bdee5149ee995747ea423f63e2&rfr_iscdi=true |