Iron deficiency, elevated erythropoietin, fibroblast growth factor 23, and mortality in the general population of the Netherlands: A cohort study

Emerging data in chronic kidney disease (CKD) patients suggest that iron deficiency and higher circulating levels of erythropoietin (EPO) stimulate the expression and concomitant cleavage of the osteocyte-derived, phosphate-regulating hormone fibroblast growth factor 23 (FGF23), a risk factor for pr...

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Veröffentlicht in:	PLoS medicine 2019-06, Vol.16 (6), p.e1002818-e1002818
Hauptverfasser:	Eisenga, Michele F, De Jong, Maarten A, Van der Meer, Peter, Leaf, David E, Huls, Gerwin, Nolte, Ilja M, Gaillard, Carlo A J M, Bakker, Stephan J L, De Borst, Martin H
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Anemia, Iron-Deficiency - blood Anemia, Iron-Deficiency - diagnosis Anemia, Iron-Deficiency - mortality Biology and Life Sciences Biomarkers - blood Chronic kidney failure Cohort analysis Cohort Studies Death End-stage renal disease Epidemiology Erythropoietin Erythropoietin - blood Female Ferritin Fibroblast growth factor 23 Fibroblast growth factors Fibroblast Growth Factors - blood Fibroblasts Glycoproteins Growth factors Health aspects Hepcidin Hormones Humans Hypotheses Hypoxia Immunoassay Internal medicine Iron Iron deficiency Iron deficiency anemia Iron deficiency diseases Kidney diseases Male Males Mediation Medical research Medicine Medicine and Health Sciences Metabolism Middle Aged Mortality Mortality - trends Nephrology Netherlands Nutrient deficiency Patient outcomes Phosphates Population Population studies Population Surveillance - methods Premature mortality Prostate cancer Regression analysis Risk factors Supervision Transferrin Transferrins
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