CRL4Mahj E3 ubiquitin ligase promotes neural stem cell reactivation

The ability of neural stem cells (NSCs) to transit between quiescence and proliferation is crucial for brain development and homeostasis. Drosophila Hippo pathway maintains NSC quiescence, but its regulation during brain development remains unknown. Here, we show that CRL4Mahj, an evolutionarily con...

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Veröffentlicht in:	PLoS biology 2019-06, Vol.17 (6), p.e3000276-e3000276
Hauptverfasser:	Ly, Phuong Thao, Tan, Ye Sing, Koe, Chwee Tat, Zhang, Yingjie, Xie, Gengqiang, Endow, Sharyn, Deng, Wu-Min, Yu, Fengwei, Wang, Hongyan
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Animals Animals, Genetically Modified - metabolism Biology and Life Sciences Brain Carrier Proteins - metabolism Carrier Proteins - physiology Cell cycle Cell proliferation Cullin Proteins - metabolism Deoxyribonucleic acid DNA DNA-binding protein DNA-Binding Proteins - metabolism DNA-Binding Proteins - physiology Drosophila melanogaster - metabolism Drosophila Proteins - metabolism Drosophila Proteins - physiology Fruit flies Genetic analysis Genetic engineering HIV Homeostasis Human immunodeficiency virus Humans Inhibition (psychology) Insects Kinases Medical schools Mutation Neural stem cells Neural Stem Cells - metabolism Neurosciences Protein Binding - physiology Proteins Regulation Regulatory mechanisms (biology) Research and Analysis Methods Signal transduction Signal Transduction - physiology Stem cells Substrates Supervision Transcription factors Tumor suppressor genes Tumorigenesis Ubiquitin Ubiquitin-protein ligase Ubiquitin-Protein Ligase Complexes - metabolism Ubiquitin-Protein Ligases - metabolism Ubiquitin-Protein Ligases - physiology Ubiquitination Warts
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