Refinement strategy for antivenom preparation of high yield and quality

Antivenoms from hyperimmune animal plasma are the only specific pharmaceuticals against snakebites. The improvement of downstream processing strategies is of great interest, not only in terms of purity profile, but also from yield-to-cost perspective and rational use of plasma of animal origin. We r...

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Veröffentlicht in:	PLoS neglected tropical diseases 2019-06, Vol.13 (6), p.e0007431-e0007431
Hauptverfasser:	Kurtović, Tihana, Lang Balija, Maja, Brgles, Marija, Sviben, Dora, Tunjić, Monika, Cajner, Hrvoje, Marchetti-Deschmann, Martina, Allmaier, Günter, Halassy, Beata
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Adsorption Anatomical structures Animals Antivenins Antivenins - immunology Antivenins - isolation & purification Antivenom Biological products Biology and Life Sciences Biotechnology Bites (Injuries) Chromatography Conformation Cost benefit analysis Fatty acids Fractionation High performance liquid chromatography Horses HPLC Immunoglobulin Fab Fragments - immunology Immunoglobulin Fab Fragments - isolation & purification Immunoglobulin G Immunoglobulins Immunologic Factors - immunology Immunologic Factors - isolation & purification Incubation period Innovations Knowledge Liquid chromatography Medicine and Health Sciences Methods Octanoic acid Pepsin Pharmaceutical chemistry Pharmaceutical research Physical Sciences Production management Proteins Purification Purity Research and Analysis Methods Saturated fatty acids Snake bites Stability Stationary phase Strategy Substrates Technology, Pharmaceutical - methods Testing Tropical diseases Venom Water purification Yield Yields
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