Two tales: Worldwide distribution of Central Asian (CAS) versus ancestral East-African Indian (EAI) lineages of Mycobacterium tuberculosis underlines a remarkable cleavage for phylogeographical, epidemiological and demographical characteristics
The East African Indian (EAI) and Central Asian (CAS) lineages of Mycobacterium tuberculosis complex (MTBC) mainly infect tuberculosis (TB) patients in the eastern hemisphere which contains many of the 22 high TB burden countries including China and India. We investigated if phylogeographical, epide...
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| description | The East African Indian (EAI) and Central Asian (CAS) lineages of Mycobacterium tuberculosis complex (MTBC) mainly infect tuberculosis (TB) patients in the eastern hemisphere which contains many of the 22 high TB burden countries including China and India. We investigated if phylogeographical, epidemiological and demographical characteristics for these 2 lineages differed in SITVIT2 database. Genotyping results and associated data (age, sex, HIV serology, drug resistance) on EAI and CAS lineages (n = 10,974 strains) were extracted. Phylogenetic and Bayesian, and other statistical analyses were used to compare isolates. The male/female sex ratio was 907/433 (2.09) for the EAI group vs. 881/544 (1.62) for CAS (p-value |
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We investigated if phylogeographical, epidemiological and demographical characteristics for these 2 lineages differed in SITVIT2 database. Genotyping results and associated data (age, sex, HIV serology, drug resistance) on EAI and CAS lineages (n = 10,974 strains) were extracted. Phylogenetic and Bayesian, and other statistical analyses were used to compare isolates. The male/female sex ratio was 907/433 (2.09) for the EAI group vs. 881/544 (1.62) for CAS (p-value<0.002). The proportion of younger patients aged 0-20 yrs. with CAS lineage was significantly higher than for EAI lineage (18.07% vs. 10.85%, p-value<0.0001). The proportion of multidrug resistant and extensively drug resistant TB among CAS group (30.63% and 1.03%, respectively) was significantly higher than in the EAI group (12.14% and 0.29%, respectively; p-value<0.0001). Lastly, the proportion of HIV+ patients was 20.34% among the EAI group vs. 3.46% in the CAS group (p-value<0.0001). This remarkable split observed between various parameters for these 2 lineages was further corroborated by their geographic distribution profile (EAI being predominantly found in Eastern-Coast of Africa, South-India and Southeast Asia, while CAS was predominantly found in Afghanistan, Pakistan, North India, Nepal, Middle-east, Libya, Sudan, Ethiopia, Kenya and Tanzania). Some geo-specificities were highlighted. This study demonstrated a remarkable cleavage for aforementioned characteristics of EAI and CAS lineages, showing a North-South divide along the tropic of cancer in Eastern hemisphere-mainly in Asia, and partly prolonged along the horn of Africa. Such studies would be helpful to better comprehend prevailing TB epidemic in context of its historical spread and evolutionary features, and provide clues to better treatment and patient-care in countries and regions concerned by these lineages.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0219706</identifier><identifier>PMID: 31299060</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adolescent ; Adult ; Africa, Eastern ; Africa, Eastern - epidemiology ; Aged ; Asia ; Asia - epidemiology ; Bacterial Typing Techniques ; Bacteriology ; Bayes Theorem ; Bayesian analysis ; Biology and Life Sciences ; Child ; Child, Preschool ; Cleavage ; DNA, Bacterial ; Drug resistance ; Drug Resistance, Microbial ; Earth Sciences ; Eastern Hemisphere ; Ecology and Environmental Sciences ; Epidemics ; Epidemiology ; Extensively Drug-Resistant Tuberculosis ; Extensively Drug-Resistant Tuberculosis - epidemiology ; Extensively Drug-Resistant Tuberculosis - microbiology ; Female ; Genetic diversity ; Genetic Variation ; Genotype ; Genotyping ; Geographical distribution ; Geography ; HIV ; Human immunodeficiency virus ; Humans ; India ; India - epidemiology ; Infant ; Infant, Newborn ; Laboratories ; Life Sciences ; Male ; Medicine and Health Sciences ; Microbiology and Parasitology ; Middle Aged ; Multidrug resistance ; Mycobacterium tuberculosis ; Mycobacterium tuberculosis - genetics ; People and Places ; Phylogeny ; Phylogeography ; Research and Analysis Methods ; Serology ; Sex ; Sex Factors ; Sex ratio ; Sexually transmitted diseases ; Statistical analysis ; STD ; Studies ; Supranationalism ; Tuberculosis ; Young Adult</subject><ispartof>PloS one, 2019-07, Vol.14 (7), p.e0219706-e0219706</ispartof><rights>2019 Couvin et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Attribution</rights><rights>2019 Couvin et al 2019 Couvin et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c564t-527557a01def017bd8194d04f75441af5426d44b96e633b783d16d2ea5795c073</citedby><cites>FETCH-LOGICAL-c564t-527557a01def017bd8194d04f75441af5426d44b96e633b783d16d2ea5795c073</cites><orcidid>0000-0002-7897-9023 ; 0000-0002-7199-7747</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6625721/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6625721/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31299060$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://riip.hal.science/pasteur-02950199$$DView record in HAL$$Hfree_for_read</backlink></links><search><contributor>Chaubey, Gyaneshwer</contributor><creatorcontrib>Couvin, David</creatorcontrib><creatorcontrib>Reynaud, Yann</creatorcontrib><creatorcontrib>Rastogi, Nalin</creatorcontrib><title>Two tales: Worldwide distribution of Central Asian (CAS) versus ancestral East-African Indian (EAI) lineages of Mycobacterium tuberculosis underlines a remarkable cleavage for phylogeographical, epidemiological and demographical characteristics</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>The East African Indian (EAI) and Central Asian (CAS) lineages of Mycobacterium tuberculosis complex (MTBC) mainly infect tuberculosis (TB) patients in the eastern hemisphere which contains many of the 22 high TB burden countries including China and India. We investigated if phylogeographical, epidemiological and demographical characteristics for these 2 lineages differed in SITVIT2 database. Genotyping results and associated data (age, sex, HIV serology, drug resistance) on EAI and CAS lineages (n = 10,974 strains) were extracted. Phylogenetic and Bayesian, and other statistical analyses were used to compare isolates. The male/female sex ratio was 907/433 (2.09) for the EAI group vs. 881/544 (1.62) for CAS (p-value<0.002). The proportion of younger patients aged 0-20 yrs. with CAS lineage was significantly higher than for EAI lineage (18.07% vs. 10.85%, p-value<0.0001). The proportion of multidrug resistant and extensively drug resistant TB among CAS group (30.63% and 1.03%, respectively) was significantly higher than in the EAI group (12.14% and 0.29%, respectively; p-value<0.0001). Lastly, the proportion of HIV+ patients was 20.34% among the EAI group vs. 3.46% in the CAS group (p-value<0.0001). This remarkable split observed between various parameters for these 2 lineages was further corroborated by their geographic distribution profile (EAI being predominantly found in Eastern-Coast of Africa, South-India and Southeast Asia, while CAS was predominantly found in Afghanistan, Pakistan, North India, Nepal, Middle-east, Libya, Sudan, Ethiopia, Kenya and Tanzania). Some geo-specificities were highlighted. This study demonstrated a remarkable cleavage for aforementioned characteristics of EAI and CAS lineages, showing a North-South divide along the tropic of cancer in Eastern hemisphere-mainly in Asia, and partly prolonged along the horn of Africa. Such studies would be helpful to better comprehend prevailing TB epidemic in context of its historical spread and evolutionary features, and provide clues to better treatment and patient-care in countries and regions concerned by these lineages.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Africa, Eastern</subject><subject>Africa, Eastern - epidemiology</subject><subject>Aged</subject><subject>Asia</subject><subject>Asia - epidemiology</subject><subject>Bacterial Typing Techniques</subject><subject>Bacteriology</subject><subject>Bayes Theorem</subject><subject>Bayesian analysis</subject><subject>Biology and Life Sciences</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Cleavage</subject><subject>DNA, Bacterial</subject><subject>Drug resistance</subject><subject>Drug Resistance, Microbial</subject><subject>Earth Sciences</subject><subject>Eastern Hemisphere</subject><subject>Ecology and Environmental Sciences</subject><subject>Epidemics</subject><subject>Epidemiology</subject><subject>Extensively Drug-Resistant Tuberculosis</subject><subject>Extensively Drug-Resistant Tuberculosis - epidemiology</subject><subject>Extensively Drug-Resistant Tuberculosis - microbiology</subject><subject>Female</subject><subject>Genetic diversity</subject><subject>Genetic Variation</subject><subject>Genotype</subject><subject>Genotyping</subject><subject>Geographical distribution</subject><subject>Geography</subject><subject>HIV</subject><subject>Human immunodeficiency virus</subject><subject>Humans</subject><subject>India</subject><subject>India - epidemiology</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Laboratories</subject><subject>Life Sciences</subject><subject>Male</subject><subject>Medicine and Health Sciences</subject><subject>Microbiology and Parasitology</subject><subject>Middle Aged</subject><subject>Multidrug resistance</subject><subject>Mycobacterium tuberculosis</subject><subject>Mycobacterium tuberculosis - genetics</subject><subject>People and Places</subject><subject>Phylogeny</subject><subject>Phylogeography</subject><subject>Research and Analysis Methods</subject><subject>Serology</subject><subject>Sex</subject><subject>Sex Factors</subject><subject>Sex ratio</subject><subject>Sexually transmitted diseases</subject><subject>Statistical analysis</subject><subject>STD</subject><subject>Studies</subject><subject>Supranationalism</subject><subject>Tuberculosis</subject><subject>Young 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characteristics</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2019-07-12</date><risdate>2019</risdate><volume>14</volume><issue>7</issue><spage>e0219706</spage><epage>e0219706</epage><pages>e0219706-e0219706</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>The East African Indian (EAI) and Central Asian (CAS) lineages of Mycobacterium tuberculosis complex (MTBC) mainly infect tuberculosis (TB) patients in the eastern hemisphere which contains many of the 22 high TB burden countries including China and India. We investigated if phylogeographical, epidemiological and demographical characteristics for these 2 lineages differed in SITVIT2 database. Genotyping results and associated data (age, sex, HIV serology, drug resistance) on EAI and CAS lineages (n = 10,974 strains) were extracted. Phylogenetic and Bayesian, and other statistical analyses were used to compare isolates. The male/female sex ratio was 907/433 (2.09) for the EAI group vs. 881/544 (1.62) for CAS (p-value<0.002). The proportion of younger patients aged 0-20 yrs. with CAS lineage was significantly higher than for EAI lineage (18.07% vs. 10.85%, p-value<0.0001). The proportion of multidrug resistant and extensively drug resistant TB among CAS group (30.63% and 1.03%, respectively) was significantly higher than in the EAI group (12.14% and 0.29%, respectively; p-value<0.0001). Lastly, the proportion of HIV+ patients was 20.34% among the EAI group vs. 3.46% in the CAS group (p-value<0.0001). This remarkable split observed between various parameters for these 2 lineages was further corroborated by their geographic distribution profile (EAI being predominantly found in Eastern-Coast of Africa, South-India and Southeast Asia, while CAS was predominantly found in Afghanistan, Pakistan, North India, Nepal, Middle-east, Libya, Sudan, Ethiopia, Kenya and Tanzania). Some geo-specificities were highlighted. This study demonstrated a remarkable cleavage for aforementioned characteristics of EAI and CAS lineages, showing a North-South divide along the tropic of cancer in Eastern hemisphere-mainly in Asia, and partly prolonged along the horn of Africa. Such studies would be helpful to better comprehend prevailing TB epidemic in context of its historical spread and evolutionary features, and provide clues to better treatment and patient-care in countries and regions concerned by these lineages.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>31299060</pmid><doi>10.1371/journal.pone.0219706</doi><orcidid>https://orcid.org/0000-0002-7897-9023</orcidid><orcidid>https://orcid.org/0000-0002-7199-7747</orcidid><oa>free_for_read</oa></addata></record> |
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| recordid | cdi_plos_journals_2256603155 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Adolescent Adult Africa, Eastern Africa, Eastern - epidemiology Aged Asia Asia - epidemiology Bacterial Typing Techniques Bacteriology Bayes Theorem Bayesian analysis Biology and Life Sciences Child Child, Preschool Cleavage DNA, Bacterial Drug resistance Drug Resistance, Microbial Earth Sciences Eastern Hemisphere Ecology and Environmental Sciences Epidemics Epidemiology Extensively Drug-Resistant Tuberculosis Extensively Drug-Resistant Tuberculosis - epidemiology Extensively Drug-Resistant Tuberculosis - microbiology Female Genetic diversity Genetic Variation Genotype Genotyping Geographical distribution Geography HIV Human immunodeficiency virus Humans India India - epidemiology Infant Infant, Newborn Laboratories Life Sciences Male Medicine and Health Sciences Microbiology and Parasitology Middle Aged Multidrug resistance Mycobacterium tuberculosis Mycobacterium tuberculosis - genetics People and Places Phylogeny Phylogeography Research and Analysis Methods Serology Sex Sex Factors Sex ratio Sexually transmitted diseases Statistical analysis STD Studies Supranationalism Tuberculosis Young Adult |
| title | Two tales: Worldwide distribution of Central Asian (CAS) versus ancestral East-African Indian (EAI) lineages of Mycobacterium tuberculosis underlines a remarkable cleavage for phylogeographical, epidemiological and demographical characteristics |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-23T08%3A19%3A35IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Two%20tales:%20Worldwide%20distribution%20of%20Central%20Asian%20(CAS)%20versus%20ancestral%20East-African%20Indian%20(EAI)%20lineages%20of%20Mycobacterium%20tuberculosis%20underlines%20a%20remarkable%20cleavage%20for%20phylogeographical,%20epidemiological%20and%20demographical%20characteristics&rft.jtitle=PloS%20one&rft.au=Couvin,%20David&rft.date=2019-07-12&rft.volume=14&rft.issue=7&rft.spage=e0219706&rft.epage=e0219706&rft.pages=e0219706-e0219706&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0219706&rft_dat=%3Cproquest_plos_%3E2257718821%3C/proquest_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2256603155&rft_id=info:pmid/31299060&rft_doaj_id=oai_doaj_org_article_89481bf9a2564d56bf88a92ccfd4ccf2&rfr_iscdi=true |