Two tales: Worldwide distribution of Central Asian (CAS) versus ancestral East-African Indian (EAI) lineages of Mycobacterium tuberculosis underlines a remarkable cleavage for phylogeographical, epidemiological and demographical characteristics

The East African Indian (EAI) and Central Asian (CAS) lineages of Mycobacterium tuberculosis complex (MTBC) mainly infect tuberculosis (TB) patients in the eastern hemisphere which contains many of the 22 high TB burden countries including China and India. We investigated if phylogeographical, epide...

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Veröffentlicht in:	PloS one 2019-07, Vol.14 (7), p.e0219706-e0219706
Hauptverfasser:	Couvin, David, Reynaud, Yann, Rastogi, Nalin
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Africa, Eastern Africa, Eastern - epidemiology Aged Asia Asia - epidemiology Bacterial Typing Techniques Bacteriology Bayes Theorem Bayesian analysis Biology and Life Sciences Child Child, Preschool Cleavage DNA, Bacterial Drug resistance Drug Resistance, Microbial Earth Sciences Eastern Hemisphere Ecology and Environmental Sciences Epidemics Epidemiology Extensively Drug-Resistant Tuberculosis Extensively Drug-Resistant Tuberculosis - epidemiology Extensively Drug-Resistant Tuberculosis - microbiology Female Genetic diversity Genetic Variation Genotype Genotyping Geographical distribution Geography HIV Human immunodeficiency virus Humans India India - epidemiology Infant Infant, Newborn Laboratories Life Sciences Male Medicine and Health Sciences Microbiology and Parasitology Middle Aged Multidrug resistance Mycobacterium tuberculosis Mycobacterium tuberculosis - genetics People and Places Phylogeny Phylogeography Research and Analysis Methods Serology Sex Sex Factors Sex ratio Sexually transmitted diseases Statistical analysis STD Studies Supranationalism Tuberculosis Young Adult
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Zusammenfassung:	The East African Indian (EAI) and Central Asian (CAS) lineages of Mycobacterium tuberculosis complex (MTBC) mainly infect tuberculosis (TB) patients in the eastern hemisphere which contains many of the 22 high TB burden countries including China and India. We investigated if phylogeographical, epidemiological and demographical characteristics for these 2 lineages differed in SITVIT2 database. Genotyping results and associated data (age, sex, HIV serology, drug resistance) on EAI and CAS lineages (n = 10,974 strains) were extracted. Phylogenetic and Bayesian, and other statistical analyses were used to compare isolates. The male/female sex ratio was 907/433 (2.09) for the EAI group vs. 881/544 (1.62) for CAS (p-value
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0219706