A preliminary study on the application of PspA as a carrier for group A meningococcal polysaccharide

This study aimed to explore the feasibility of pneumococcal surface protein A (PspA) as a carrier protein. Three recombinant pneumococcal surface proteins from three different clades were expressed by the prokaryotic expression system and conjugated to group A meningococcal polysaccharide (GAMP) to...

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Veröffentlicht in:	PloS one 2019-07, Vol.14 (7), p.e0218427-e0218427
Hauptverfasser:	Wang, Lichan, Tan, Yajun, Wei, Chen, Zhang, Huajie, Luo, Peng, Zhang, Shumin, Ma, Xiao
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Bacterial - immunology Antigens Bacterial proteins Bacterial Proteins - immunology Bacterial Proteins - pharmacology Bactericidal activity Biology and Life Sciences Conjugates Conjugation Diphtheria Diphtheria toxoid Enzyme-linked immunosorbent assay Enzymes Epidemics Feasibility studies Female Flow cytometry Food Genetic aspects Immunity (Disease) Immunization Immunoglobulin G Immunoglobulin G - immunology Immunoglobulins Laboratories Lymphocytes T Medical immunity Medicine and Health Sciences Meningitis Meningococcal Infections - immunology Meningococcal Infections - prevention & control Meningococcal Vaccines - immunology Meningococcal Vaccines - pharmacology Mice Mice, Inbred BALB C Neisseria meningitidis - immunology Physiological aspects Polysaccharides Polysaccharides, Bacterial - immunology Polysaccharides, Bacterial - pharmacology Preliminary Data Prevention Properties Protein A Proteins PspA protein Quality Research and Analysis Methods Salmonella Serum bactericidal activity Streptococcus infections Surface protein A T cells Tetanus Tetanus toxoid Toxins Transport proteins Typhoid Vaccines Vaccines, Conjugate - immunology Vaccines, Conjugate - pharmacology
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