A20 in dendritic cells restrains intestinal anti-bacterial peptide expression and preserves commensal homeostasis

Microbial dysbiosis commonly occurs in patients with inflammatory bowel diseases (IBD). Exogenous causes of dysbiosis such as antibiotics and diet are well described, but host derived causes are understudied. A20 is a potent regulator of signals triggered by microbial pattern molecules, and A20 regu...

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Veröffentlicht in:	PloS one 2019-07, Vol.14 (7), p.e0218999
Hauptverfasser:	Talpin, Alice, Kattah, Michael G, Advincula, Rommel, Fadrosh, Douglas, Lynch, Kole, LaMere, Brandon, Fujimura, Kei E, Nagalingam, Nabeetha A, Malynn, Barbara A, Lynch, Susan V, Ma, Averil
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Bacterial Agents - pharmacology Antibacterial agents Antibiotics Antiinfectives and antibacterials Asthma Biology and Life Sciences CD11c antigen Colitis Dendritic cells Dendritic Cells - microbiology Development and progression Disease susceptibility Dysbacteriosis Dysbiosis Dysbiosis - drug therapy Dysbiosis - genetics Dysbiosis - microbiology Enzymes Epithelial cells Feces Gastrointestinal Microbiome - drug effects Gene expression Gene Expression Regulation - drug effects Genes Genetic aspects Health aspects Homeostasis Host-bacteria relationships Humans Inflammation Inflammation - drug therapy Inflammation - genetics Inflammation - microbiology Inflammatory bowel disease Inflammatory bowel diseases Inflammatory Bowel Diseases - drug therapy Inflammatory Bowel Diseases - genetics Inflammatory Bowel Diseases - microbiology Intestinal microflora Intestine Intestines Intestines - microbiology Lymphocytes Medicine Medicine and Health Sciences Mice Mice, Knockout Microbiota Microbiota (Symbiotic organisms) Microorganisms Pancreatitis-Associated Proteins - genetics Peptides Peptides - pharmacology Perturbation Phylogenetics Physiological aspects Ribonuclease, Pancreatic - genetics Risk factors Symbiosis - drug effects Tumor necrosis factor Tumor Necrosis Factor alpha-Induced Protein 3 - genetics Weaning
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