Twice upon a time: The progression of canine visceral leishmaniasis in an Argentinean city
Canine Visceral Leishmaniasis (CVL) prevalence, spatial distribution and associated factors were assessed in four locations in Iguazú department in 2014 and in Puerto Iguazú city again in 2018. The city areas were divided into a grid of 400x400m cells. All cells were sampled in 2014 and a random sub...
Gespeichert in:
| Veröffentlicht in: | PloS one 2019-07, Vol.14 (7), p.e0219395-e0219395 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | e0219395 |
|---|---|
| container_issue | 7 |
| container_start_page | e0219395 |
| container_title | PloS one |
| container_volume | 14 |
| creator | Lamattina, Daniela Berrozpe, Pablo Eduardo Casas, Natalia Moya, Sofía Lorian Giuliani, Magalí Gabriela Costa, Sebastián Andrés Arrabal, Juan Pablo Martínez, Mariela Florencia Rivero, María Romina Salas, Martín Humeres, Cristian Alejandro Liotta, Domingo Javier Meichtry, María Belén Salomón, Oscar Daniel |
| description | Canine Visceral Leishmaniasis (CVL) prevalence, spatial distribution and associated factors were assessed in four locations in Iguazú department in 2014 and in Puerto Iguazú city again in 2018. The city areas were divided into a grid of 400x400m cells. All cells were sampled in 2014 and a random subsampling was developed in 2018. In each cell, five dogs clustered in a 'critical scenario' (prone to have vectors) were sampled. A rapid immunochromatographic dipstick was used to detect antibodies against Leishmania infantum, confirming by lymph node smears observation and PCR. For Puerto Iguazú, Generalized Linear Models (GLMs) were constructed considering environmental, dog and clinical variables. Pearson's Chi square and Fisher's exact tests were employed to evaluate the association between CVL, dog clinical signs and infestation with other parasites. Cartographic outputs were made and Moran's I indices were calculated as spatial autocorrelation indicators. CVL prevalence rates were 26.18% in 2014 and 17.50% in 2018. No associations were established in environmental models, but dog age and repellent use were significant when running 2014 dog models. Clinical models showed significant associations between seropositive dogs and ophthalmological, dermal signs and onychogryphosis in 2014. In 2018, only adenomegaly was associated. The results of global Moran´s I were not significant but regarding local analysis, six sites in 2014 and one in 2018 presented autocorrelation with neighboring sites. The decrease in CVL prevalence may be associated to transmission stabilization, which could explain the lack of associations with dog-related variables. Further, spatial distribution of CVL is a poor evidence for design of transmission control measures but could be important in case of intensive parasite circulation or when the first autochthonous cases appear. For control success, sensitivity of diagnostic methods, political will and adequate material resources remain critical. Modeling of multiple variables will be required to identify factors that drive disease stabilization/destabilization. |
| doi_str_mv | 10.1371/journal.pone.0219395 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_2252704486</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A592311634</galeid><doaj_id>oai_doaj_org_article_2fa1d5b893a0499595f694ea453936fd</doaj_id><sourcerecordid>A592311634</sourcerecordid><originalsourceid>FETCH-LOGICAL-c692t-81a7a6614f0398a0041310a224ad5e16a080b17ad92145575e6c08760e9e8b0f3</originalsourceid><addsrcrecordid>eNqNk02L1EAQhoMo7rr6D0QDguhhxv5Id9IehGHxY2BhQUcPXpqapJL0kKTH7mR1_72dnewykT1IDt1Unnor9aYqip5TsqQ8pe92dnAdNMu97XBJGFVciQfRaTjZQjLCHx7dT6In3u8IETyT8nF0wilLpUj5afRz89vkGA9BJYa4Ny2-jzc1xntnK4femxC3ZZxDZzqMr4zP0UETN2h83YYgeONjE3K7eOUq7PqAhXtu-uun0aMSGo_PpvMs-v7p4-b8y-Li8vP6fHWxyKVi_SKjkIKUNCkJVxkQklBOCTCWQCGQSiAZ2dIUCsVoIkQqUOYkSyVBhdmWlPwsennQ3TfW68kWrxkTLCVJkslArA9EYWGn98604K61BaNvAtZVGlxv8gY1K4EWYpspDiRRSihRSpUgJIIrLssiaH2Yqg3bFos8tBwMmYnO33Sm1pW90qFFKjkNAm8mAWd_Deh73Y6uNg10aIeb7-YsY4qO6Kt_0Pu7m6gKQgOmK22om4-ieiUU42PZJFDLe6jwFNiaPMxQaUJ8lvB2lhCYHv_0FQze6_W3r__PXv6Ys6-P2Bqh6Wtvm6EPo-bnYHIAc2e9d1jemUyJHlfg1g09roCeViCkvTj-QXdJtzPP_wJpC_6q</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2252704486</pqid></control><display><type>article</type><title>Twice upon a time: The progression of canine visceral leishmaniasis in an Argentinean city</title><source>Public Library of Science (PLoS) Journals Open Access</source><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><creator>Lamattina, Daniela ; Berrozpe, Pablo Eduardo ; Casas, Natalia ; Moya, Sofía Lorian ; Giuliani, Magalí Gabriela ; Costa, Sebastián Andrés ; Arrabal, Juan Pablo ; Martínez, Mariela Florencia ; Rivero, María Romina ; Salas, Martín ; Humeres, Cristian Alejandro ; Liotta, Domingo Javier ; Meichtry, María Belén ; Salomón, Oscar Daniel</creator><creatorcontrib>Lamattina, Daniela ; Berrozpe, Pablo Eduardo ; Casas, Natalia ; Moya, Sofía Lorian ; Giuliani, Magalí Gabriela ; Costa, Sebastián Andrés ; Arrabal, Juan Pablo ; Martínez, Mariela Florencia ; Rivero, María Romina ; Salas, Martín ; Humeres, Cristian Alejandro ; Liotta, Domingo Javier ; Meichtry, María Belén ; Salomón, Oscar Daniel</creatorcontrib><description>Canine Visceral Leishmaniasis (CVL) prevalence, spatial distribution and associated factors were assessed in four locations in Iguazú department in 2014 and in Puerto Iguazú city again in 2018. The city areas were divided into a grid of 400x400m cells. All cells were sampled in 2014 and a random subsampling was developed in 2018. In each cell, five dogs clustered in a 'critical scenario' (prone to have vectors) were sampled. A rapid immunochromatographic dipstick was used to detect antibodies against Leishmania infantum, confirming by lymph node smears observation and PCR. For Puerto Iguazú, Generalized Linear Models (GLMs) were constructed considering environmental, dog and clinical variables. Pearson's Chi square and Fisher's exact tests were employed to evaluate the association between CVL, dog clinical signs and infestation with other parasites. Cartographic outputs were made and Moran's I indices were calculated as spatial autocorrelation indicators. CVL prevalence rates were 26.18% in 2014 and 17.50% in 2018. No associations were established in environmental models, but dog age and repellent use were significant when running 2014 dog models. Clinical models showed significant associations between seropositive dogs and ophthalmological, dermal signs and onychogryphosis in 2014. In 2018, only adenomegaly was associated. The results of global Moran´s I were not significant but regarding local analysis, six sites in 2014 and one in 2018 presented autocorrelation with neighboring sites. The decrease in CVL prevalence may be associated to transmission stabilization, which could explain the lack of associations with dog-related variables. Further, spatial distribution of CVL is a poor evidence for design of transmission control measures but could be important in case of intensive parasite circulation or when the first autochthonous cases appear. For control success, sensitivity of diagnostic methods, political will and adequate material resources remain critical. Modeling of multiple variables will be required to identify factors that drive disease stabilization/destabilization.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0219395</identifier><identifier>PMID: 31276573</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Animals ; Antibodies ; Autocorrelation ; Biology and Life Sciences ; Brazil - epidemiology ; Cartography ; Chi square analysis ; Chi-square test ; Cities ; Destabilization ; Development and progression ; Diagnostic systems ; Disease Progression ; Distribution ; Dog diseases ; Dog Diseases - diagnosis ; Dog Diseases - epidemiology ; Dog Diseases - parasitology ; Dogs ; Ecosystems ; EDTA ; Environment models ; Environmental modeling ; Epidemiology ; Geography, Medical ; Infestation ; Leishmania infantum ; Leishmaniasis ; Leishmaniasis, Visceral - veterinary ; Lymph nodes ; Medicine and Health Sciences ; Parasites ; Parasitic diseases ; People and places ; Prevalence ; Risk factors ; Sentinel surveillance ; Skin ; Spatial distribution ; Stabilization ; Statistical models ; Trends ; Vector-borne diseases ; Vectors ; Visceral leishmaniasis</subject><ispartof>PloS one, 2019-07, Vol.14 (7), p.e0219395-e0219395</ispartof><rights>COPYRIGHT 2019 Public Library of Science</rights><rights>2019 Lamattina et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2019 Lamattina et al 2019 Lamattina et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-81a7a6614f0398a0041310a224ad5e16a080b17ad92145575e6c08760e9e8b0f3</citedby><cites>FETCH-LOGICAL-c692t-81a7a6614f0398a0041310a224ad5e16a080b17ad92145575e6c08760e9e8b0f3</cites><orcidid>0000-0002-4441-0234 ; 0000-0002-5926-8234 ; 0000-0001-7255-748X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6611631/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6611631/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79342,79343</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31276573$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lamattina, Daniela</creatorcontrib><creatorcontrib>Berrozpe, Pablo Eduardo</creatorcontrib><creatorcontrib>Casas, Natalia</creatorcontrib><creatorcontrib>Moya, Sofía Lorian</creatorcontrib><creatorcontrib>Giuliani, Magalí Gabriela</creatorcontrib><creatorcontrib>Costa, Sebastián Andrés</creatorcontrib><creatorcontrib>Arrabal, Juan Pablo</creatorcontrib><creatorcontrib>Martínez, Mariela Florencia</creatorcontrib><creatorcontrib>Rivero, María Romina</creatorcontrib><creatorcontrib>Salas, Martín</creatorcontrib><creatorcontrib>Humeres, Cristian Alejandro</creatorcontrib><creatorcontrib>Liotta, Domingo Javier</creatorcontrib><creatorcontrib>Meichtry, María Belén</creatorcontrib><creatorcontrib>Salomón, Oscar Daniel</creatorcontrib><title>Twice upon a time: The progression of canine visceral leishmaniasis in an Argentinean city</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Canine Visceral Leishmaniasis (CVL) prevalence, spatial distribution and associated factors were assessed in four locations in Iguazú department in 2014 and in Puerto Iguazú city again in 2018. The city areas were divided into a grid of 400x400m cells. All cells were sampled in 2014 and a random subsampling was developed in 2018. In each cell, five dogs clustered in a 'critical scenario' (prone to have vectors) were sampled. A rapid immunochromatographic dipstick was used to detect antibodies against Leishmania infantum, confirming by lymph node smears observation and PCR. For Puerto Iguazú, Generalized Linear Models (GLMs) were constructed considering environmental, dog and clinical variables. Pearson's Chi square and Fisher's exact tests were employed to evaluate the association between CVL, dog clinical signs and infestation with other parasites. Cartographic outputs were made and Moran's I indices were calculated as spatial autocorrelation indicators. CVL prevalence rates were 26.18% in 2014 and 17.50% in 2018. No associations were established in environmental models, but dog age and repellent use were significant when running 2014 dog models. Clinical models showed significant associations between seropositive dogs and ophthalmological, dermal signs and onychogryphosis in 2014. In 2018, only adenomegaly was associated. The results of global Moran´s I were not significant but regarding local analysis, six sites in 2014 and one in 2018 presented autocorrelation with neighboring sites. The decrease in CVL prevalence may be associated to transmission stabilization, which could explain the lack of associations with dog-related variables. Further, spatial distribution of CVL is a poor evidence for design of transmission control measures but could be important in case of intensive parasite circulation or when the first autochthonous cases appear. For control success, sensitivity of diagnostic methods, political will and adequate material resources remain critical. Modeling of multiple variables will be required to identify factors that drive disease stabilization/destabilization.</description><subject>Animals</subject><subject>Antibodies</subject><subject>Autocorrelation</subject><subject>Biology and Life Sciences</subject><subject>Brazil - epidemiology</subject><subject>Cartography</subject><subject>Chi square analysis</subject><subject>Chi-square test</subject><subject>Cities</subject><subject>Destabilization</subject><subject>Development and progression</subject><subject>Diagnostic systems</subject><subject>Disease Progression</subject><subject>Distribution</subject><subject>Dog diseases</subject><subject>Dog Diseases - diagnosis</subject><subject>Dog Diseases - epidemiology</subject><subject>Dog Diseases - parasitology</subject><subject>Dogs</subject><subject>Ecosystems</subject><subject>EDTA</subject><subject>Environment models</subject><subject>Environmental modeling</subject><subject>Epidemiology</subject><subject>Geography, Medical</subject><subject>Infestation</subject><subject>Leishmania infantum</subject><subject>Leishmaniasis</subject><subject>Leishmaniasis, Visceral - veterinary</subject><subject>Lymph nodes</subject><subject>Medicine and Health Sciences</subject><subject>Parasites</subject><subject>Parasitic diseases</subject><subject>People and places</subject><subject>Prevalence</subject><subject>Risk factors</subject><subject>Sentinel surveillance</subject><subject>Skin</subject><subject>Spatial distribution</subject><subject>Stabilization</subject><subject>Statistical models</subject><subject>Trends</subject><subject>Vector-borne diseases</subject><subject>Vectors</subject><subject>Visceral leishmaniasis</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNk02L1EAQhoMo7rr6D0QDguhhxv5Id9IehGHxY2BhQUcPXpqapJL0kKTH7mR1_72dnewykT1IDt1Unnor9aYqip5TsqQ8pe92dnAdNMu97XBJGFVciQfRaTjZQjLCHx7dT6In3u8IETyT8nF0wilLpUj5afRz89vkGA9BJYa4Ny2-jzc1xntnK4femxC3ZZxDZzqMr4zP0UETN2h83YYgeONjE3K7eOUq7PqAhXtu-uun0aMSGo_PpvMs-v7p4-b8y-Li8vP6fHWxyKVi_SKjkIKUNCkJVxkQklBOCTCWQCGQSiAZ2dIUCsVoIkQqUOYkSyVBhdmWlPwsennQ3TfW68kWrxkTLCVJkslArA9EYWGn98604K61BaNvAtZVGlxv8gY1K4EWYpspDiRRSihRSpUgJIIrLssiaH2Yqg3bFos8tBwMmYnO33Sm1pW90qFFKjkNAm8mAWd_Deh73Y6uNg10aIeb7-YsY4qO6Kt_0Pu7m6gKQgOmK22om4-ieiUU42PZJFDLe6jwFNiaPMxQaUJ8lvB2lhCYHv_0FQze6_W3r__PXv6Ys6-P2Bqh6Wtvm6EPo-bnYHIAc2e9d1jemUyJHlfg1g09roCeViCkvTj-QXdJtzPP_wJpC_6q</recordid><startdate>20190705</startdate><enddate>20190705</enddate><creator>Lamattina, Daniela</creator><creator>Berrozpe, Pablo Eduardo</creator><creator>Casas, Natalia</creator><creator>Moya, Sofía Lorian</creator><creator>Giuliani, Magalí Gabriela</creator><creator>Costa, Sebastián Andrés</creator><creator>Arrabal, Juan Pablo</creator><creator>Martínez, Mariela Florencia</creator><creator>Rivero, María Romina</creator><creator>Salas, Martín</creator><creator>Humeres, Cristian Alejandro</creator><creator>Liotta, Domingo Javier</creator><creator>Meichtry, María Belén</creator><creator>Salomón, Oscar Daniel</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-4441-0234</orcidid><orcidid>https://orcid.org/0000-0002-5926-8234</orcidid><orcidid>https://orcid.org/0000-0001-7255-748X</orcidid></search><sort><creationdate>20190705</creationdate><title>Twice upon a time: The progression of canine visceral leishmaniasis in an Argentinean city</title><author>Lamattina, Daniela ; Berrozpe, Pablo Eduardo ; Casas, Natalia ; Moya, Sofía Lorian ; Giuliani, Magalí Gabriela ; Costa, Sebastián Andrés ; Arrabal, Juan Pablo ; Martínez, Mariela Florencia ; Rivero, María Romina ; Salas, Martín ; Humeres, Cristian Alejandro ; Liotta, Domingo Javier ; Meichtry, María Belén ; Salomón, Oscar Daniel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-81a7a6614f0398a0041310a224ad5e16a080b17ad92145575e6c08760e9e8b0f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Animals</topic><topic>Antibodies</topic><topic>Autocorrelation</topic><topic>Biology and Life Sciences</topic><topic>Brazil - epidemiology</topic><topic>Cartography</topic><topic>Chi square analysis</topic><topic>Chi-square test</topic><topic>Cities</topic><topic>Destabilization</topic><topic>Development and progression</topic><topic>Diagnostic systems</topic><topic>Disease Progression</topic><topic>Distribution</topic><topic>Dog diseases</topic><topic>Dog Diseases - diagnosis</topic><topic>Dog Diseases - epidemiology</topic><topic>Dog Diseases - parasitology</topic><topic>Dogs</topic><topic>Ecosystems</topic><topic>EDTA</topic><topic>Environment models</topic><topic>Environmental modeling</topic><topic>Epidemiology</topic><topic>Geography, Medical</topic><topic>Infestation</topic><topic>Leishmania infantum</topic><topic>Leishmaniasis</topic><topic>Leishmaniasis, Visceral - veterinary</topic><topic>Lymph nodes</topic><topic>Medicine and Health Sciences</topic><topic>Parasites</topic><topic>Parasitic diseases</topic><topic>People and places</topic><topic>Prevalence</topic><topic>Risk factors</topic><topic>Sentinel surveillance</topic><topic>Skin</topic><topic>Spatial distribution</topic><topic>Stabilization</topic><topic>Statistical models</topic><topic>Trends</topic><topic>Vector-borne diseases</topic><topic>Vectors</topic><topic>Visceral leishmaniasis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lamattina, Daniela</creatorcontrib><creatorcontrib>Berrozpe, Pablo Eduardo</creatorcontrib><creatorcontrib>Casas, Natalia</creatorcontrib><creatorcontrib>Moya, Sofía Lorian</creatorcontrib><creatorcontrib>Giuliani, Magalí Gabriela</creatorcontrib><creatorcontrib>Costa, Sebastián Andrés</creatorcontrib><creatorcontrib>Arrabal, Juan Pablo</creatorcontrib><creatorcontrib>Martínez, Mariela Florencia</creatorcontrib><creatorcontrib>Rivero, María Romina</creatorcontrib><creatorcontrib>Salas, Martín</creatorcontrib><creatorcontrib>Humeres, Cristian Alejandro</creatorcontrib><creatorcontrib>Liotta, Domingo Javier</creatorcontrib><creatorcontrib>Meichtry, María Belén</creatorcontrib><creatorcontrib>Salomón, Oscar Daniel</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection (ProQuest)</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lamattina, Daniela</au><au>Berrozpe, Pablo Eduardo</au><au>Casas, Natalia</au><au>Moya, Sofía Lorian</au><au>Giuliani, Magalí Gabriela</au><au>Costa, Sebastián Andrés</au><au>Arrabal, Juan Pablo</au><au>Martínez, Mariela Florencia</au><au>Rivero, María Romina</au><au>Salas, Martín</au><au>Humeres, Cristian Alejandro</au><au>Liotta, Domingo Javier</au><au>Meichtry, María Belén</au><au>Salomón, Oscar Daniel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Twice upon a time: The progression of canine visceral leishmaniasis in an Argentinean city</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2019-07-05</date><risdate>2019</risdate><volume>14</volume><issue>7</issue><spage>e0219395</spage><epage>e0219395</epage><pages>e0219395-e0219395</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Canine Visceral Leishmaniasis (CVL) prevalence, spatial distribution and associated factors were assessed in four locations in Iguazú department in 2014 and in Puerto Iguazú city again in 2018. The city areas were divided into a grid of 400x400m cells. All cells were sampled in 2014 and a random subsampling was developed in 2018. In each cell, five dogs clustered in a 'critical scenario' (prone to have vectors) were sampled. A rapid immunochromatographic dipstick was used to detect antibodies against Leishmania infantum, confirming by lymph node smears observation and PCR. For Puerto Iguazú, Generalized Linear Models (GLMs) were constructed considering environmental, dog and clinical variables. Pearson's Chi square and Fisher's exact tests were employed to evaluate the association between CVL, dog clinical signs and infestation with other parasites. Cartographic outputs were made and Moran's I indices were calculated as spatial autocorrelation indicators. CVL prevalence rates were 26.18% in 2014 and 17.50% in 2018. No associations were established in environmental models, but dog age and repellent use were significant when running 2014 dog models. Clinical models showed significant associations between seropositive dogs and ophthalmological, dermal signs and onychogryphosis in 2014. In 2018, only adenomegaly was associated. The results of global Moran´s I were not significant but regarding local analysis, six sites in 2014 and one in 2018 presented autocorrelation with neighboring sites. The decrease in CVL prevalence may be associated to transmission stabilization, which could explain the lack of associations with dog-related variables. Further, spatial distribution of CVL is a poor evidence for design of transmission control measures but could be important in case of intensive parasite circulation or when the first autochthonous cases appear. For control success, sensitivity of diagnostic methods, political will and adequate material resources remain critical. Modeling of multiple variables will be required to identify factors that drive disease stabilization/destabilization.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>31276573</pmid><doi>10.1371/journal.pone.0219395</doi><tpages>e0219395</tpages><orcidid>https://orcid.org/0000-0002-4441-0234</orcidid><orcidid>https://orcid.org/0000-0002-5926-8234</orcidid><orcidid>https://orcid.org/0000-0001-7255-748X</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2019-07, Vol.14 (7), p.e0219395-e0219395 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_2252704486 |
| source | Public Library of Science (PLoS) Journals Open Access; MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Animals Antibodies Autocorrelation Biology and Life Sciences Brazil - epidemiology Cartography Chi square analysis Chi-square test Cities Destabilization Development and progression Diagnostic systems Disease Progression Distribution Dog diseases Dog Diseases - diagnosis Dog Diseases - epidemiology Dog Diseases - parasitology Dogs Ecosystems EDTA Environment models Environmental modeling Epidemiology Geography, Medical Infestation Leishmania infantum Leishmaniasis Leishmaniasis, Visceral - veterinary Lymph nodes Medicine and Health Sciences Parasites Parasitic diseases People and places Prevalence Risk factors Sentinel surveillance Skin Spatial distribution Stabilization Statistical models Trends Vector-borne diseases Vectors Visceral leishmaniasis |
| title | Twice upon a time: The progression of canine visceral leishmaniasis in an Argentinean city |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-08T02%3A02%3A41IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Twice%20upon%20a%20time:%20The%20progression%20of%20canine%20visceral%20leishmaniasis%20in%20an%20Argentinean%20city&rft.jtitle=PloS%20one&rft.au=Lamattina,%20Daniela&rft.date=2019-07-05&rft.volume=14&rft.issue=7&rft.spage=e0219395&rft.epage=e0219395&rft.pages=e0219395-e0219395&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0219395&rft_dat=%3Cgale_plos_%3EA592311634%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2252704486&rft_id=info:pmid/31276573&rft_galeid=A592311634&rft_doaj_id=oai_doaj_org_article_2fa1d5b893a0499595f694ea453936fd&rfr_iscdi=true |