Implications of environmental and pathogen-specific determinants on clinical presentations and disease outcome in melioidosis patients
Melioidosis is gaining recognition as an emerging infectious disease with diverse clinical manifestations and high-case fatality rates worldwide. However, the molecular epidemiology of the disease outside the endemic regions such as northeast part of Thailand and northern Australia remains unclear....
Gespeichert in:
| Veröffentlicht in: | PLoS neglected tropical diseases 2019-05, Vol.13 (5), p.e0007312 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 5 |
| container_start_page | e0007312 |
| container_title | PLoS neglected tropical diseases |
| container_volume | 13 |
| creator | Shaw, Tushar Tellapragada, Chaitanya Kamath, Asha Kalwaje Eshwara, Vandana Mukhopadhyay, Chiranjay |
| description | Melioidosis is gaining recognition as an emerging infectious disease with diverse clinical manifestations and high-case fatality rates worldwide. However, the molecular epidemiology of the disease outside the endemic regions such as northeast part of Thailand and northern Australia remains unclear.
Clinical data and B. pseudomallei isolates obtained from 199 culture-confirmed cases of melioidosis diagnosed during 2006-2016 in South India were used to elucidate the host and pathogen specific variable virulence determinants associated with clinical presentations and disease outcome. Further, we determined the temporal variations and the influence of ecological factors on B.pseudomallei Lipopolysaccharide (LPS) genotypes causing infections. Severe forms of the disease were observed amongst 169 (85%) patients. Renal dysfunction and infection due to B.pseudomallei harboring BimABm variant had significant associations with severe forms of the disease. Diabetes mellitus, septicemic melioidosis and infection due to LPSB genotype were independent risk factors for mortality. LPSB (74%) and LPSA (20.6%) were the prevalent genotypes causing infections. Both genotypes demonstrated temporal variations and had significant correlations with rainfall and humidity.
Our study findings suggest that the pathogen specific virulence traits under the influence of ecological factors are the key drivers for geographical variations in the molecular epidemiology of melioidosis. |
| doi_str_mv | 10.1371/journal.pntd.0007312 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_2252318776</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A587702354</galeid><doaj_id>oai_doaj_org_article_787982d3bcb449cb8108e1142bede8e6</doaj_id><sourcerecordid>A587702354</sourcerecordid><originalsourceid>FETCH-LOGICAL-c624t-c64e172c77ed6d4f6858343f5ddcaf51904e34e8ed077a14699472b664ba98cb3</originalsourceid><addsrcrecordid>eNptkt-K1DAUxoso7rr6BqIFQfZmxvxrk94sLIuuAwve6HVIk9OZDGlSk3bBF_C5TXe6y4wshTQkv-_LOYevKN5jtMaU4y_7MEWv3Hrwo1kjhDjF5EVxjhtarQin1cuj_VnxJqU9QlVTCfy6OKMYNZg06Lz4u-kHZ7UabfCpDF0J_t7G4Hvwo3Kl8qYc1LgLW_CrNIC2ndWlgRFib73yY9b4Ujvrs4crhwhpFh7cZrGxCVSCMkyjDj2U1pc9OBusCcmm2dtmQXpbvOqUS_Bu-V8Uv759_XnzfXX343Zzc3230jVhY14ZYE4052Bqw7paVIIy2lXGaNVVuEEMKAMBBnGuMKubhnHS1jVrVSN0Sy-KjwffwYUklxEmSUhFKBac15nYHAgT1F4O0fYq_pFBWflwEOJWqjha7UBywRtBDG11y1ijW4GRAIwZacHkGmavq-W1qe3B6NxpVO7E9PTG253chntZV1RgIbLB5WIQw-8J0ih7mzQ4pzyEaa47V81qjElGP_2HPt_dQm1VbsD6LuR39Wwqr6tMIEIrlqn1M1T-DPRWBw-dzecngs9Hgh0oN-5ScNNDDk5BdgB1DClF6J6GgZGcY_1YtZxjLZdYZ9mH40E-iR5zTP8Bx_T3RQ</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2252318776</pqid></control><display><type>article</type><title>Implications of environmental and pathogen-specific determinants on clinical presentations and disease outcome in melioidosis patients</title><source>MEDLINE</source><source>Directory of Open Access Journals - May need to register for free articles</source><source>PubMed Central Open Access</source><source>Public Library of Science (PLoS)(OpenAccess)</source><source>PubMed Central</source><source>EZB Electronic Journals Library</source><creator>Shaw, Tushar ; Tellapragada, Chaitanya ; Kamath, Asha ; Kalwaje Eshwara, Vandana ; Mukhopadhyay, Chiranjay</creator><contributor>Poonawala, Husain</contributor><creatorcontrib>Shaw, Tushar ; Tellapragada, Chaitanya ; Kamath, Asha ; Kalwaje Eshwara, Vandana ; Mukhopadhyay, Chiranjay ; Poonawala, Husain</creatorcontrib><description>Melioidosis is gaining recognition as an emerging infectious disease with diverse clinical manifestations and high-case fatality rates worldwide. However, the molecular epidemiology of the disease outside the endemic regions such as northeast part of Thailand and northern Australia remains unclear.
Clinical data and B. pseudomallei isolates obtained from 199 culture-confirmed cases of melioidosis diagnosed during 2006-2016 in South India were used to elucidate the host and pathogen specific variable virulence determinants associated with clinical presentations and disease outcome. Further, we determined the temporal variations and the influence of ecological factors on B.pseudomallei Lipopolysaccharide (LPS) genotypes causing infections. Severe forms of the disease were observed amongst 169 (85%) patients. Renal dysfunction and infection due to B.pseudomallei harboring BimABm variant had significant associations with severe forms of the disease. Diabetes mellitus, septicemic melioidosis and infection due to LPSB genotype were independent risk factors for mortality. LPSB (74%) and LPSA (20.6%) were the prevalent genotypes causing infections. Both genotypes demonstrated temporal variations and had significant correlations with rainfall and humidity.
Our study findings suggest that the pathogen specific virulence traits under the influence of ecological factors are the key drivers for geographical variations in the molecular epidemiology of melioidosis.</description><identifier>ISSN: 1935-2735</identifier><identifier>ISSN: 1935-2727</identifier><identifier>EISSN: 1935-2735</identifier><identifier>DOI: 10.1371/journal.pntd.0007312</identifier><identifier>PMID: 31091290</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Analysis ; Biology and Life Sciences ; Burkholderia pseudomallei - classification ; Burkholderia pseudomallei - genetics ; Burkholderia pseudomallei - isolation & purification ; Burkholderia pseudomallei - pathogenicity ; Care and treatment ; Case studies ; Child ; Communicable diseases ; Diabetes ; Diabetes mellitus ; Earth Sciences ; Ecological effects ; Ecology and Environmental Sciences ; Environment ; Environmental factors ; Environmental impact ; Epidemiology ; Female ; Genes ; Genetic diversity ; Genotype ; Genotypes ; Geographical variations ; Higher education ; Humans ; Humidity ; India - epidemiology ; Infection ; Infections ; Infectious diseases ; Lipopolysaccharides ; Male ; Medicine and Health Sciences ; Melioidosis ; Melioidosis - epidemiology ; Melioidosis - microbiology ; Microbiology ; Middle Aged ; Mitogens ; Molecular Epidemiology ; Motility ; Outcome and process assessment (Medical care) ; Pathogens ; People and Places ; Pseudomonas infections ; Public health ; Rain ; Rainfall ; Renal function ; Risk analysis ; Risk factors ; Temporal variations ; Tropical diseases ; Virulence ; Virulence (Microbiology) ; Young Adult</subject><ispartof>PLoS neglected tropical diseases, 2019-05, Vol.13 (5), p.e0007312</ispartof><rights>COPYRIGHT 2019 Public Library of Science</rights><rights>2019 Shaw et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2019 Shaw et al 2019 Shaw et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c624t-c64e172c77ed6d4f6858343f5ddcaf51904e34e8ed077a14699472b664ba98cb3</citedby><cites>FETCH-LOGICAL-c624t-c64e172c77ed6d4f6858343f5ddcaf51904e34e8ed077a14699472b664ba98cb3</cites><orcidid>0000-0002-0117-5369 ; 0000-0003-0402-1143</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6538188/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6538188/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2095,2914,23846,27903,27904,53770,53772,79347,79348</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31091290$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Poonawala, Husain</contributor><creatorcontrib>Shaw, Tushar</creatorcontrib><creatorcontrib>Tellapragada, Chaitanya</creatorcontrib><creatorcontrib>Kamath, Asha</creatorcontrib><creatorcontrib>Kalwaje Eshwara, Vandana</creatorcontrib><creatorcontrib>Mukhopadhyay, Chiranjay</creatorcontrib><title>Implications of environmental and pathogen-specific determinants on clinical presentations and disease outcome in melioidosis patients</title><title>PLoS neglected tropical diseases</title><addtitle>PLoS Negl Trop Dis</addtitle><description>Melioidosis is gaining recognition as an emerging infectious disease with diverse clinical manifestations and high-case fatality rates worldwide. However, the molecular epidemiology of the disease outside the endemic regions such as northeast part of Thailand and northern Australia remains unclear.
Clinical data and B. pseudomallei isolates obtained from 199 culture-confirmed cases of melioidosis diagnosed during 2006-2016 in South India were used to elucidate the host and pathogen specific variable virulence determinants associated with clinical presentations and disease outcome. Further, we determined the temporal variations and the influence of ecological factors on B.pseudomallei Lipopolysaccharide (LPS) genotypes causing infections. Severe forms of the disease were observed amongst 169 (85%) patients. Renal dysfunction and infection due to B.pseudomallei harboring BimABm variant had significant associations with severe forms of the disease. Diabetes mellitus, septicemic melioidosis and infection due to LPSB genotype were independent risk factors for mortality. LPSB (74%) and LPSA (20.6%) were the prevalent genotypes causing infections. Both genotypes demonstrated temporal variations and had significant correlations with rainfall and humidity.
Our study findings suggest that the pathogen specific virulence traits under the influence of ecological factors are the key drivers for geographical variations in the molecular epidemiology of melioidosis.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Analysis</subject><subject>Biology and Life Sciences</subject><subject>Burkholderia pseudomallei - classification</subject><subject>Burkholderia pseudomallei - genetics</subject><subject>Burkholderia pseudomallei - isolation & purification</subject><subject>Burkholderia pseudomallei - pathogenicity</subject><subject>Care and treatment</subject><subject>Case studies</subject><subject>Child</subject><subject>Communicable diseases</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Earth Sciences</subject><subject>Ecological effects</subject><subject>Ecology and Environmental Sciences</subject><subject>Environment</subject><subject>Environmental factors</subject><subject>Environmental impact</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Genes</subject><subject>Genetic diversity</subject><subject>Genotype</subject><subject>Genotypes</subject><subject>Geographical variations</subject><subject>Higher education</subject><subject>Humans</subject><subject>Humidity</subject><subject>India - epidemiology</subject><subject>Infection</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Lipopolysaccharides</subject><subject>Male</subject><subject>Medicine and Health Sciences</subject><subject>Melioidosis</subject><subject>Melioidosis - epidemiology</subject><subject>Melioidosis - microbiology</subject><subject>Microbiology</subject><subject>Middle Aged</subject><subject>Mitogens</subject><subject>Molecular Epidemiology</subject><subject>Motility</subject><subject>Outcome and process assessment (Medical care)</subject><subject>Pathogens</subject><subject>People and Places</subject><subject>Pseudomonas infections</subject><subject>Public health</subject><subject>Rain</subject><subject>Rainfall</subject><subject>Renal function</subject><subject>Risk analysis</subject><subject>Risk factors</subject><subject>Temporal variations</subject><subject>Tropical diseases</subject><subject>Virulence</subject><subject>Virulence (Microbiology)</subject><subject>Young Adult</subject><issn>1935-2735</issn><issn>1935-2727</issn><issn>1935-2735</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>DOA</sourceid><recordid>eNptkt-K1DAUxoso7rr6BqIFQfZmxvxrk94sLIuuAwve6HVIk9OZDGlSk3bBF_C5TXe6y4wshTQkv-_LOYevKN5jtMaU4y_7MEWv3Hrwo1kjhDjF5EVxjhtarQin1cuj_VnxJqU9QlVTCfy6OKMYNZg06Lz4u-kHZ7UabfCpDF0J_t7G4Hvwo3Kl8qYc1LgLW_CrNIC2ndWlgRFib73yY9b4Ujvrs4crhwhpFh7cZrGxCVSCMkyjDj2U1pc9OBusCcmm2dtmQXpbvOqUS_Bu-V8Uv759_XnzfXX343Zzc3230jVhY14ZYE4052Bqw7paVIIy2lXGaNVVuEEMKAMBBnGuMKubhnHS1jVrVSN0Sy-KjwffwYUklxEmSUhFKBac15nYHAgT1F4O0fYq_pFBWflwEOJWqjha7UBywRtBDG11y1ijW4GRAIwZacHkGmavq-W1qe3B6NxpVO7E9PTG253chntZV1RgIbLB5WIQw-8J0ih7mzQ4pzyEaa47V81qjElGP_2HPt_dQm1VbsD6LuR39Wwqr6tMIEIrlqn1M1T-DPRWBw-dzecngs9Hgh0oN-5ScNNDDk5BdgB1DClF6J6GgZGcY_1YtZxjLZdYZ9mH40E-iR5zTP8Bx_T3RQ</recordid><startdate>20190501</startdate><enddate>20190501</enddate><creator>Shaw, Tushar</creator><creator>Tellapragada, Chaitanya</creator><creator>Kamath, Asha</creator><creator>Kalwaje Eshwara, Vandana</creator><creator>Mukhopadhyay, Chiranjay</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7SS</scope><scope>7T2</scope><scope>7T7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>F1W</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>H95</scope><scope>H97</scope><scope>K9.</scope><scope>L.G</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-0117-5369</orcidid><orcidid>https://orcid.org/0000-0003-0402-1143</orcidid></search><sort><creationdate>20190501</creationdate><title>Implications of environmental and pathogen-specific determinants on clinical presentations and disease outcome in melioidosis patients</title><author>Shaw, Tushar ; Tellapragada, Chaitanya ; Kamath, Asha ; Kalwaje Eshwara, Vandana ; Mukhopadhyay, Chiranjay</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c624t-c64e172c77ed6d4f6858343f5ddcaf51904e34e8ed077a14699472b664ba98cb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Analysis</topic><topic>Biology and Life Sciences</topic><topic>Burkholderia pseudomallei - classification</topic><topic>Burkholderia pseudomallei - genetics</topic><topic>Burkholderia pseudomallei - isolation & purification</topic><topic>Burkholderia pseudomallei - pathogenicity</topic><topic>Care and treatment</topic><topic>Case studies</topic><topic>Child</topic><topic>Communicable diseases</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Earth Sciences</topic><topic>Ecological effects</topic><topic>Ecology and Environmental Sciences</topic><topic>Environment</topic><topic>Environmental factors</topic><topic>Environmental impact</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Genes</topic><topic>Genetic diversity</topic><topic>Genotype</topic><topic>Genotypes</topic><topic>Geographical variations</topic><topic>Higher education</topic><topic>Humans</topic><topic>Humidity</topic><topic>India - epidemiology</topic><topic>Infection</topic><topic>Infections</topic><topic>Infectious diseases</topic><topic>Lipopolysaccharides</topic><topic>Male</topic><topic>Medicine and Health Sciences</topic><topic>Melioidosis</topic><topic>Melioidosis - epidemiology</topic><topic>Melioidosis - microbiology</topic><topic>Microbiology</topic><topic>Middle Aged</topic><topic>Mitogens</topic><topic>Molecular Epidemiology</topic><topic>Motility</topic><topic>Outcome and process assessment (Medical care)</topic><topic>Pathogens</topic><topic>People and Places</topic><topic>Pseudomonas infections</topic><topic>Public health</topic><topic>Rain</topic><topic>Rainfall</topic><topic>Renal function</topic><topic>Risk analysis</topic><topic>Risk factors</topic><topic>Temporal variations</topic><topic>Tropical diseases</topic><topic>Virulence</topic><topic>Virulence (Microbiology)</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shaw, Tushar</creatorcontrib><creatorcontrib>Tellapragada, Chaitanya</creatorcontrib><creatorcontrib>Kamath, Asha</creatorcontrib><creatorcontrib>Kalwaje Eshwara, Vandana</creatorcontrib><creatorcontrib>Mukhopadhyay, Chiranjay</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 3: Aquatic Pollution & Environmental Quality</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>Directory of Open Access Journals - May need to register for free articles</collection><jtitle>PLoS neglected tropical diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shaw, Tushar</au><au>Tellapragada, Chaitanya</au><au>Kamath, Asha</au><au>Kalwaje Eshwara, Vandana</au><au>Mukhopadhyay, Chiranjay</au><au>Poonawala, Husain</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Implications of environmental and pathogen-specific determinants on clinical presentations and disease outcome in melioidosis patients</atitle><jtitle>PLoS neglected tropical diseases</jtitle><addtitle>PLoS Negl Trop Dis</addtitle><date>2019-05-01</date><risdate>2019</risdate><volume>13</volume><issue>5</issue><spage>e0007312</spage><pages>e0007312-</pages><issn>1935-2735</issn><issn>1935-2727</issn><eissn>1935-2735</eissn><abstract>Melioidosis is gaining recognition as an emerging infectious disease with diverse clinical manifestations and high-case fatality rates worldwide. However, the molecular epidemiology of the disease outside the endemic regions such as northeast part of Thailand and northern Australia remains unclear.
Clinical data and B. pseudomallei isolates obtained from 199 culture-confirmed cases of melioidosis diagnosed during 2006-2016 in South India were used to elucidate the host and pathogen specific variable virulence determinants associated with clinical presentations and disease outcome. Further, we determined the temporal variations and the influence of ecological factors on B.pseudomallei Lipopolysaccharide (LPS) genotypes causing infections. Severe forms of the disease were observed amongst 169 (85%) patients. Renal dysfunction and infection due to B.pseudomallei harboring BimABm variant had significant associations with severe forms of the disease. Diabetes mellitus, septicemic melioidosis and infection due to LPSB genotype were independent risk factors for mortality. LPSB (74%) and LPSA (20.6%) were the prevalent genotypes causing infections. Both genotypes demonstrated temporal variations and had significant correlations with rainfall and humidity.
Our study findings suggest that the pathogen specific virulence traits under the influence of ecological factors are the key drivers for geographical variations in the molecular epidemiology of melioidosis.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>31091290</pmid><doi>10.1371/journal.pntd.0007312</doi><orcidid>https://orcid.org/0000-0002-0117-5369</orcidid><orcidid>https://orcid.org/0000-0003-0402-1143</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1935-2735 |
| ispartof | PLoS neglected tropical diseases, 2019-05, Vol.13 (5), p.e0007312 |
| issn | 1935-2735 1935-2727 1935-2735 |
| language | eng |
| recordid | cdi_plos_journals_2252318776 |
| source | MEDLINE; Directory of Open Access Journals - May need to register for free articles; PubMed Central Open Access; Public Library of Science (PLoS)(OpenAccess); PubMed Central; EZB Electronic Journals Library |
| subjects | Adolescent Adult Aged Aged, 80 and over Analysis Biology and Life Sciences Burkholderia pseudomallei - classification Burkholderia pseudomallei - genetics Burkholderia pseudomallei - isolation & purification Burkholderia pseudomallei - pathogenicity Care and treatment Case studies Child Communicable diseases Diabetes Diabetes mellitus Earth Sciences Ecological effects Ecology and Environmental Sciences Environment Environmental factors Environmental impact Epidemiology Female Genes Genetic diversity Genotype Genotypes Geographical variations Higher education Humans Humidity India - epidemiology Infection Infections Infectious diseases Lipopolysaccharides Male Medicine and Health Sciences Melioidosis Melioidosis - epidemiology Melioidosis - microbiology Microbiology Middle Aged Mitogens Molecular Epidemiology Motility Outcome and process assessment (Medical care) Pathogens People and Places Pseudomonas infections Public health Rain Rainfall Renal function Risk analysis Risk factors Temporal variations Tropical diseases Virulence Virulence (Microbiology) Young Adult |
| title | Implications of environmental and pathogen-specific determinants on clinical presentations and disease outcome in melioidosis patients |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-22T14%3A53%3A03IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Implications%20of%20environmental%20and%20pathogen-specific%20determinants%20on%20clinical%20presentations%20and%20disease%20outcome%20in%20melioidosis%20patients&rft.jtitle=PLoS%20neglected%20tropical%20diseases&rft.au=Shaw,%20Tushar&rft.date=2019-05-01&rft.volume=13&rft.issue=5&rft.spage=e0007312&rft.pages=e0007312-&rft.issn=1935-2735&rft.eissn=1935-2735&rft_id=info:doi/10.1371/journal.pntd.0007312&rft_dat=%3Cgale_plos_%3EA587702354%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2252318776&rft_id=info:pmid/31091290&rft_galeid=A587702354&rft_doaj_id=oai_doaj_org_article_787982d3bcb449cb8108e1142bede8e6&rfr_iscdi=true |