The arginine sensing and transport binding sites are distinct in the human pathogen Leishmania

The intracellular protozoan parasite Leishmania donovani causes human visceral leishmaniasis. Intracellular L. donovani that proliferate inside macrophage phagolysosomes compete with the host for arginine, creating a situation that endangers parasite survival. Parasites have a sensor that upon argin...

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Veröffentlicht in:	PLoS neglected tropical diseases 2019-04, Vol.13 (4), p.e0007304-e0007304
Hauptverfasser:	Pawar, Harsh, Puri, Madhu, Fischer Weinberger, Renana, Madhubala, Rentala, Zilberstein, Dan
Format:	Artikel
Sprache:	eng
Schlagworte:	Amastigotes Amino Acid Transport Systems, Basic - genetics Amino Acid Transport Systems, Basic - metabolism Amino acids Arginine Arginine - analogs & derivatives Arginine - metabolism Binding Sites Biological Transport Biology Biology and Life Sciences Cell culture Deprivation Gene Expression Regulation Genetic aspects Health aspects Humans Infections Intracellular Kinases Leishmania Leishmania donovani - genetics Leishmania donovani - metabolism Leishmaniasis Life sciences Ligands Macrophages Macrophages - parasitology Medicine and Health Sciences Metabolism Observations Parasites Parasitic diseases Pathogens Penicillin Pentamidine Phagolysosomes Phagosomes - parasitology Physical Sciences Polyamines Promastigotes Protein binding Proteins Protozoa Protozoan Proteins - genetics Protozoan Proteins - metabolism Research and Analysis Methods Sensors Survival THP-1 Cells Transport Transport proteins Trends Tropical diseases Vector-borne diseases Virulence (Microbiology) Visceral leishmaniasis
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