Innovative digital technologies for quality assurance of diagnosis of human African trypanosomiasis
The diagnostic algorithm for HAT involves two steps: first, a screening by an antibody detection test such as the card agglutination test for trypanosomiasis (CATT)/T.b. gambiense or a Rapid Diagnostic Test (RDT) to identify suspects, followed by a set of confirmation tests, usually the direct micro...
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| Veröffentlicht in: | PLoS neglected tropical diseases 2018-09, Vol.12 (9), p.e0006664-e0006664 |
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| creator | Hasker, Epco Kwete, Jean Inocencio da Luz, Raquel Mpanya, Alain Bebronne, Nicolas Makabuza, Jacquies Claeys, Yves Ilunga, Jérémie Lejon, Veerle Mumba Ngoyi, Dieudonné Büscher, Philippe Boelaert, Marleen Miaka, Erick Mwamba |
| description | The diagnostic algorithm for HAT involves two steps: first, a screening by an antibody detection test such as the card agglutination test for trypanosomiasis (CATT)/T.b. gambiense or a Rapid Diagnostic Test (RDT) to identify suspects, followed by a set of confirmation tests, usually the direct microscopic examination of lymph node puncture aspirate and/or Giemsa-stained thick blood film, followed by a concentration method on blood such as the microhematocrit centrifugation technique (mHCT) or the mini-Anion Exchange Centrifugation Technique (mAECT) (Fig 1). The same limitations that apply to storing slides would apply to proficiency panels being sent out by a reference lab. Because of these obvious constraints, HAT control programs have so far only focused on IQA. [...]it may happen that false negative slides do occur, and depending on the threshold chosen in the LQAS approach, a certain number of false negatives may be accepted [6]. [...]QA in HAT diagnostics is needed and is technically feasible. |
| doi_str_mv | 10.1371/journal.pntd.0006664 |
| format | Article |
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The same limitations that apply to storing slides would apply to proficiency panels being sent out by a reference lab. Because of these obvious constraints, HAT control programs have so far only focused on IQA. [...]it may happen that false negative slides do occur, and depending on the threshold chosen in the LQAS approach, a certain number of false negatives may be accepted [6]. [...]QA in HAT diagnostics is needed and is technically feasible.</description><identifier>ISSN: 1935-2735</identifier><identifier>ISSN: 1935-2727</identifier><identifier>EISSN: 1935-2735</identifier><identifier>DOI: 10.1371/journal.pntd.0006664</identifier><identifier>PMID: 30212459</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>African trypanosomiasis ; Agglutination ; Agglutination tests ; Algorithms ; Analysis ; Anion exchange ; Anion exchanging ; Anions ; Antibodies ; Biology and Life Sciences ; Blood ; Blood levels ; Centrifugation ; Centrifuging ; Control programs ; Detection ; Diagnosis ; Diagnostic systems ; Disease control ; Engineering and Technology ; International organizations ; Lymph ; Lymph nodes ; Medical diagnostic software ; Medical laboratories ; Medicine ; Medicine and Health Sciences ; Microscopy ; Parasitology ; Policy Platform ; Public health ; Quality assurance ; Quality control ; Research and Analysis Methods ; Tropical diseases ; Tuberculosis ; Vector-borne diseases</subject><ispartof>PLoS neglected tropical diseases, 2018-09, Vol.12 (9), p.e0006664-e0006664</ispartof><rights>COPYRIGHT 2018 Public Library of Science</rights><rights>2018 Hasker et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. 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| subjects | African trypanosomiasis Agglutination Agglutination tests Algorithms Analysis Anion exchange Anion exchanging Anions Antibodies Biology and Life Sciences Blood Blood levels Centrifugation Centrifuging Control programs Detection Diagnosis Diagnostic systems Disease control Engineering and Technology International organizations Lymph Lymph nodes Medical diagnostic software Medical laboratories Medicine Medicine and Health Sciences Microscopy Parasitology Policy Platform Public health Quality assurance Quality control Research and Analysis Methods Tropical diseases Tuberculosis Vector-borne diseases |
| title | Innovative digital technologies for quality assurance of diagnosis of human African trypanosomiasis |
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