Broadly resistant HIV-1 against CD4-binding site neutralizing antibodies

Recently identified broadly neutralizing antibodies (bnAbs) show great potential for clinical interventions against HIV-1 infection. However, resistant strains may impose substantial challenges. Here, we report on the identification and characterization of a panel of HIV-1 strains with broad and pot...

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Veröffentlicht in:	PLoS pathogens 2019-06, Vol.15 (6), p.e1007819
Hauptverfasser:	Zhou, Panpan, Wang, Han, Fang, Mengqi, Li, Yangyang, Wang, Hua, Shi, Shasha, Li, Zihao, Wu, Jiapeng, Han, Xiaoxu, Shi, Xuanling, Shang, Hong, Zhou, Tongqing, Zhang, Linqi
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired immune deficiency syndrome AIDS Analysis Antibodies Antibodies, Neutralizing - genetics Antibodies, Neutralizing - immunology Antigenic determinants Binding sites Biology Biology and Life Sciences Care and treatment CD4 antigen CD4 Antigens - genetics CD4 Antigens - immunology Cell Line Cell surface Collaboration Disease prevention Epitopes Epitopes - genetics Epitopes - immunology Glycoprotein gp120 Glycoproteins HIV HIV Antibodies - genetics HIV Antibodies - immunology HIV Envelope Protein gp120 - genetics HIV Envelope Protein gp120 - immunology HIV infections HIV-1 - genetics HIV-1 - immunology Human immunodeficiency virus Humans Immunoglobulins Immunology Infection Infectious diseases Laboratories Medical diagnosis Medicine Medicine and Health Sciences Mutagenesis Mutation Neutralizing Outcome and process assessment (Medical care) Prevention Research and Analysis Methods Site-directed mutagenesis Trimers Vaccines Viruses
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