Limited HIV-2 reservoirs in central-memory CD4 T-cells associated to CXCR6 co-receptor expression in attenuated HIV-2 infection

The low pathogenicity and replicative potential of HIV-2 are still poorly understood. We investigated whether HIV-2 reservoirs might follow the peculiar distribution reported in models of attenuated HIV-1/SIV infections, i.e. limited infection of central-memory CD4 T lymphocytes (TCM). Antiretrovira...

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Veröffentlicht in:	PLoS pathogens 2019-05, Vol.15 (5), p.e1007758-e1007758
Hauptverfasser:	Samri, Assia, Charpentier, Charlotte, Diallo, Mariama Sadjo, Bertine, Mélanie, Even, Sophie, Morin, Véronique, Oudin, Anne, Parizot, Christophe, Collin, Gilles, Hosmalin, Anne, Cheynier, Rémi, Thiébaut, Rodolphe, Matheron, Sophie, Collin, Fideline, Zoorob, Rima, Brun-Vézinet, Françoise, Autran, Brigitte
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired immune deficiency syndrome Activation Adaptive immunology Adult Aged AIDS Antiretroviral agents Attenuation Biology and Life Sciences Carrier Proteins - genetics Carrier Proteins - metabolism Case-Control Studies CCR5 protein CD4 antigen CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - metabolism CD4-Positive T-Lymphocytes - virology CD8 antigen Cell surface Cells, Cultured Cytometry Deoxyribonucleic acid DNA Female Flow cytometry Funding Gene expression Genetic aspects Hepatitis HIV HIV infections HIV Infections - immunology HIV Infections - metabolism HIV Infections - virology HIV tests HIV-2 - genetics HIV-2 - immunology Human health and pathology Human immunodeficiency virus Humans Immunologic Memory - immunology Immunological memory Immunology Infection Infections Infectious diseases Leukocytes (mononuclear) Leukocytes, Mononuclear - immunology Leukocytes, Mononuclear - metabolism Leukocytes, Mononuclear - virology Life Sciences Lymphocytes Lymphocytes T Male Medicine and Health Sciences Memory cells Microbiology and Parasitology Middle Aged Monocytes Pathogenicity Pathogens Peripheral blood mononuclear cells Receptors Receptors, CXCR6 - genetics Receptors, CXCR6 - metabolism Simian immunodeficiency virus Supervision Surface markers T cells Transcriptome Virology
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