LANA oligomeric architecture is essential for KSHV nuclear body formation and viral genome maintenance during latency

The molecular basis for the formation of functional, higher-ordered macro-molecular domains is not completely known. The Kaposi's Sarcoma-Associated Herpesvirus (KSHV) genome forms a super-molecular domain structure during latent infection that is strictly dependent on the DNA binding of the vi...

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Veröffentlicht in:	PLoS pathogens 2019-01, Vol.15 (1), p.e1007489-e1007489
Hauptverfasser:	De Leo, Alessandra, Deng, Zhong, Vladimirova, Olga, Chen, Horng-Shen, Dheekollu, Jayaraju, Calderon, Abram, Myers, Kenneth A, Hayden, James, Keeney, Frederick, Kaufer, Benedikt B, Yuan, Yan, Robertson, Erle, Lieberman, Paul M
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens Architecture Binding Binding sites Biology and Life Sciences Cell cycle Cell division Cellular proteins Chromatin Chromosomes Daxx protein Deoxyribonucleic acid DNA Domains Epigenetics Gene expression Genetic engineering Genomes Genomics Herpesviruses Infection Infections Kaposi's sarcoma Kaposis sarcoma Latency Latent infection Medicine and Health Sciences Methods Microscopy Molecular structure Mutants Oligomerization Oligomers Proteins Risk factors Sarcoma Stem cells Transcription Virology
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