Zika virus infection at mid-gestation results in fetal cerebral cortical injury and fetal death in the olive baboon

Zika virus (ZIKV) infection during pregnancy in humans is associated with an increased incidence of congenital anomalies including microcephaly as well as fetal death and miscarriage and collectively has been referred to as Congenital Zika Syndrome (CZS). Animal models for ZIKV infection in pregnanc...

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Veröffentlicht in:	PLoS pathogens 2019-01, Vol.15 (1), p.e1007507-e1007507
Hauptverfasser:	Gurung, Sunam, Reuter, Nicole, Preno, Alisha, Dubaut, Jamie, Nadeau, Hugh, Hyatt, Kimberly, Singleton, Krista, Martin, Ashley, Parks, W Tony, Papin, James F, Myers, Dean A
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animal models Animals Baboons Biology and life sciences Brain Brain - pathology Cerebral cortex Cerebral Cortex - injuries Cerebral Cortex - pathology Cerebral Cortex - virology Congenital anomalies Congenital defects Conjunctivitis Cord blood Cortex (frontal) Dark money Death Disease Models, Animal Diseases and pests Drug dosages Female Fetal Death Fetal Diseases - pathology Fetus - virology Fetuses Fibers Genetic disorders Gestation Gynecology Health aspects Health sciences Hypoxia Immunoglobulin G Immunoglobulin M Infection Infections Infectious Disease Transmission, Vertical Inflammation Inflammatory response Interleukin 1 Interleukin 15 Interleukin 16 Interleukin 2 Interleukin 6 Interleukin 7 Medicine and Health Sciences Microcephaly Microencephaly Microglia Migration Miscarriage Mortality Mosquitoes Neuronal-glial interactions Neurons Obstetrics Papio anubis Papio anubis - microbiology Papio anubis - virology Pathogenesis Pathology Placenta Placenta - virology Pregnancy Pregnancy Complications, Infectious - virology Pregnant women Primates Prognosis Rash Ribonucleic acid Risk factors RNA Supervision Tissues Vector-borne diseases Viremia Viruses West Nile virus Zika virus Zika Virus - genetics Zika Virus - pathogenicity Zika virus infection Zika Virus Infection - pathology Zika Virus Infection - virology
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