Multiple components of the nuclear pore complex interact with the amino-terminus of MX2 to facilitate HIV-1 restriction

Human myxovirus resistance 2 (MX2/MXB) is an interferon-induced post-entry inhibitor of human immunodeficiency virus type-1 (HIV-1) infection. While the precise mechanism of viral inhibition remains unclear, MX2 is localized to the nuclear envelope, and blocks the nuclear import of viral cDNAs. The...

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Veröffentlicht in:	PLoS pathogens 2018-11, Vol.14 (11), p.e1007408-e1007408
Hauptverfasser:	Dicks, Matthew D J, Betancor, Gilberto, Jimenez-Guardeño, Jose M, Pessel-Vivares, Lucie, Apolonia, Luis, Goujon, Caroline, Malim, Michael H
Format:	Artikel
Sprache:	eng
Schlagworte:	Active Transport, Cell Nucleus Amino acids Antiviral activity Antiviral agents Antiviral Agents - metabolism Arginine beta Karyopherins - metabolism Binding sites Biological response modifiers Biology Biology and Life Sciences CD4 antigen Cell lines Coding Depletion Fluorescence Fluorescence microscopy Funding Glycine HEK293 Cells HeLa Cells HIV HIV Infections - metabolism HIV Infections - virology HIV-1 - physiology Host-Pathogen Interactions Human immunodeficiency virus Humans Immunology Immunoprecipitation Imports Infection Infections Infectious diseases Interferon Interferons - metabolism Localization Lymphocytes Lymphocytes T Machinery and equipment Medicine and Health Sciences Microscopy Mutation Myxovirus Resistance Proteins - genetics Myxovirus Resistance Proteins - metabolism Nuclear Envelope - metabolism Nuclear Pore - metabolism Nuclear Pore - physiology Nuclear Pore Complex Proteins - metabolism Nuclear transport Nucleoporins Phenylalanine Proteins Research and Analysis Methods RNA RNA-mediated interference Screening T cells Virus Replication Viruses Yeast Yeasts
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