Apolipoprotein E is an HIV-1-inducible inhibitor of viral production and infectivity in macrophages

Apolipoprotein E (ApoE) belongs to a class of cellular proteins involved in lipid metabolism. ApoE is a polymorphic protein produced primarily in macrophages and astrocytes. Different isoforms of ApoE have been associated with susceptibility to various diseases including Alzheimer's and cardiov...

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Veröffentlicht in:	PLoS pathogens 2018-11, Vol.14 (11), p.e1007372-e1007372
Hauptverfasser:	Siddiqui, Rokeya, Suzu, Shinya, Ueno, Mikinori, Nasser, Hesham, Koba, Ryota, Bhuyan, Farzana, Noyori, Osamu, Hamidi, Sofiane, Sheng, Guojun, Yasuda-Inoue, Mariko, Hishiki, Takayuki, Sukegawa, Sayaka, Miyagi, Eri, Strebel, Klaus, Matsushita, Shuzo, Shimotohno, Kunitada, Ariumi, Yasuo
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired immune deficiency syndrome Adult AIDS Alzheimer's disease Amino acids Antigen presentation Antiviral activity Apolipoprotein E Apolipoproteins Apolipoproteins - metabolism Apolipoproteins E - metabolism Apolipoproteins E - physiology Astrocytes Biology and Life Sciences Cardiovascular diseases CD4-Positive T-Lymphocytes - metabolism Cell surface Cellular proteins Deoxyribonucleic acid Disease susceptibility DNA DNA damage env Gene Products, Human Immunodeficiency Virus - metabolism Gene Expression Regulation - genetics Genes Glycoprotein gp160 Heart diseases HEK293 Cells Heparan sulfate Hepatitis Hepatitis C HIV HIV Envelope Protein gp120 - metabolism HIV Envelope Protein gp41 - metabolism HIV Infections - metabolism HIV Infections - prevention & control HIV-1 - metabolism Human immunodeficiency virus Humans Infection Infections Infectious diseases Infectivity Inhibitors Isoforms Kinases Life cycles Lipid metabolism Lipids Lipoproteins Localization Lysosomes Macrophages Macrophages - metabolism Macrophages - virology Male Medicine and Health Sciences Metabolism Monocytes Overexpression Pathogenesis Protein turnover Proteins Research and analysis methods Supervision T cells Up-Regulation Veterinary medicine Viral diseases Virus Replication - genetics Virus Replication - physiology
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