HIV-1 envelope glycan modifications that permit neutralization by germline-reverted VRC01-class broadly neutralizing antibodies

Broadly neutralizing antibody (bnAb) induction is a high priority for effective HIV-1 vaccination. VRC01-class bnAbs that target the CD4 binding site (CD4bs) of trimeric HIV-1 envelope (Env) glycoprotein spikes are particularly attractive to elicit because of their extraordinary breadth and potency...

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Veröffentlicht in:	PLoS pathogens 2018-11, Vol.14 (11), p.e1007431-e1007431
Hauptverfasser:	LaBranche, Celia C, McGuire, Andrew T, Gray, Matthew D, Behrens, Shay, Kwong, Peter D, Chen, Xuejun, Zhou, Tongqing, Sattentau, Quentin J, Peacock, James, Eaton, Amanda, Greene, Kelli, Gao, Hongmei, Tang, Haili, Perez, Lautaro G, Saunders, Kevin O, Mascola, John R, Haynes, Barton F, Stamatatos, Leonidas, Montefiori, David C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Antibodies Antibodies, Monoclonal - immunology Antibodies, Neutralizing - immunology Antigens B-Lymphocytes - immunology Binding Sites Biology and Life Sciences Broadly Neutralizing Antibodies Cancer CD4 antigen CD4 Antigens - immunology Clonal deletion env Gene Products, Human Immunodeficiency Virus - immunology Epitopes - immunology Gene deletion Gene mutations Genetic aspects Glycan Glycoproteins Glycosylation HIV HIV (Viruses) HIV Antibodies - immunology HIV Envelope Protein gp120 - immunology HIV Infections - immunology HIV Seropositivity HIV-1 - immunology Human immunodeficiency virus Humans Immunoglobulins Immunology Infectious diseases Lymphocytes B Medical research Medicine Medicine and Health Sciences Mutation N-glycans Neutralization Neutralizing Polysaccharides Polysaccharides - immunology Polysaccharides - metabolism Receptors Research and analysis methods Supervision Surgery Trimers Vaccination Vaccines Viral antibodies Virology Viruses
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