Macrophage activation by IFN-γ triggers restriction of phagosomal copper from intracellular pathogens

Copper toxicity and copper limitation can both be effective host defense mechanisms against pathogens. Tolerance of high copper by fungi makes toxicity as a defense mechanism largely ineffective against fungal pathogens. A forward genetic screen for Histoplasma capsulatum mutant yeasts unable to rep...

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Veröffentlicht in:	PLoS pathogens 2018-11, Vol.14 (11), p.e1007444
Hauptverfasser:	Shen, Qian, Beucler, Matthew J, Ray, Stephanie C, Rappleye, Chad A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptive immunity Animals Antiporters - metabolism Attenuation Biology and Life Sciences Cation Transport Proteins - metabolism Cell activation Cell Line Copper Copper - metabolism Copper - toxicity CTR3 gene Defense mechanisms Deoxyribonucleic acid DNA Fungi Gene expression Genetic screening Histoplasma - immunology Histoplasma - metabolism Histoplasmosis Histoplasmosis - metabolism Immune response Immune system Immunity Immunological tolerance Infections Innate immunity Interferon-gamma - metabolism Intracellular Iron Iron - metabolism Macrophage Activation - physiology Macrophages Medicine and Health Sciences Mice Mice, Inbred C57BL Mutation Pathogens Phagocytes Phagosomes Phagosomes - metabolism Physical sciences Proteins Salmonella Switches Toxicity Transcription Tuberculosis Yeast Yeasts γ-Interferon
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