A bispecific immunotweezer prevents soluble PrP oligomers and abolishes prion toxicity

Antibodies to the prion protein, PrP, represent a promising therapeutic approach against prion diseases but the neurotoxicity of certain anti-PrP antibodies has caused concern. Here we describe scPOM-bi, a bispecific antibody designed to function as a molecular prion tweezer. scPOM-bi combines the c...

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Veröffentlicht in:	PLoS pathogens 2018-10, Vol.14 (10), p.e1007335-e1007335
Hauptverfasser:	Bardelli, Marco, Frontzek, Karl, Simonelli, Luca, Hornemann, Simone, Pedotti, Mattia, Mazzola, Federica, Carta, Manfredi, Eckhardt, Valeria, D'Antuono, Rocco, Virgilio, Tommaso, González, Santiago F, Aguzzi, Adriano, Varani, Luca
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer's disease Animals Antibodies Antibodies, Bispecific - immunology Antibodies, Bispecific - pharmacology Binding sites Biology and Life Sciences Bispecific antibodies Cells, Cultured Cerebellum Cerebellum - immunology Complementarity Complementarity Determining Regions - immunology Creutzfeldt-Jakob disease Immunoglobulins Immunotherapy Medicine and Health Sciences Mice Mice, Transgenic Neurodegeneration Neuropathology Neuroprotection Neurotoxicity Oligomers Physical Sciences Prion Diseases - immunology Prion Diseases - therapy Prion protein Prion Proteins - immunology Prions Prions - immunology Prions - toxicity Proteins Research and Analysis Methods Toxicity
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