EspH is a hypervirulence factor for Mycobacterium marinum and essential for the secretion of the ESX-1 substrates EspE and EspF

The pathogen Mycobacterium tuberculosis employs a range of ESX-1 substrates to manipulate the host and build a successful infection. Although the importance of ESX-1 secretion in virulence is well established, the characterization of its individual components and the role of individual substrates is...

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Veröffentlicht in:	PLoS pathogens 2018-08, Vol.14 (8), p.e1007247-e1007247
Hauptverfasser:	Phan, Trang H, van Leeuwen, Lisanne M, Kuijl, Coen, Ummels, Roy, van Stempvoort, Gunny, Rubio-Canalejas, Alba, Piersma, Sander R, Jiménez, Connie R, van der Sar, Astrid M, Houben, Edith N G, Bitter, Wilbert
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bacterial Proteins - genetics Bacterial Proteins - metabolism Biology and Life Sciences Cell culture Cell surface Cells, Cultured Clonal deletion Defects Disease control E coli Embryo, Nonmammalian Genetic aspects Granuloma Infections Laboratories Larva Larvae Medicine and Health Sciences Mice Mutants Mycobacterium marinum Mycobacterium marinum - genetics Mycobacterium marinum - metabolism Mycobacterium marinum - pathogenicity Mycobacterium tuberculosis Pathogens Phagocytes Phenotypes Physiological aspects Proteins RAW 264.7 Cells Research and Analysis Methods Secretion Sheep Substrates Supervision Tuberculosis Type VII Secretion Systems - genetics Type VII Secretion Systems - metabolism Virulence Virulence (Microbiology) Virulence - genetics Virulence Factors - genetics Virulence Factors - physiology Zebrafish Zebrafish - embryology Zebrafish - growth & development
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