Distinct evolutionary dynamics of horizontal gene transfer in drug resistant and virulent clones of Klebsiella pneumoniae

Klebsiella pneumoniae has emerged as an important cause of two distinct public health threats: multi-drug resistant (MDR) healthcare-associated infections and drug susceptible community-acquired invasive infections. These pathotypes are generally associated with two distinct subsets of K. pneumoniae...

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Veröffentlicht in:	PLoS genetics 2019-04, Vol.15 (4), p.e1008114-e1008114
Hauptverfasser:	Wyres, Kelly L, Wick, Ryan R, Judd, Louise M, Froumine, Roni, Tokolyi, Alex, Gorrie, Claire L, Lam, Margaret M C, Duchêne, Sebastián, Jenney, Adam, Holt, Kathryn E
Format:	Artikel
Sprache:	eng
Schlagworte:	Antimicrobial agents Bacterial Capsules - genetics Bacterial Capsules - metabolism Bacteriophages - genetics Biochemistry Bioinformatics Biotechnology Cloning CRISPR Cross Infection - drug therapy Cross Infection - microbiology Disease susceptibility Drug resistance Drug Resistance, Bacterial - genetics Drug Resistance, Multiple, Bacterial - genetics Epidemics Epidemiology Evolution Evolution, Molecular Evolutionary genetics Gene transfer Gene Transfer, Horizontal Genes Genetic aspects Genetic research Genetic transformation Genetic Variation Genome, Bacterial Genomes Genomics Hospitals Humans Infection Infections Infectious diseases Klebsiella Klebsiella Infections - drug therapy Klebsiella Infections - microbiology Klebsiella pneumoniae Klebsiella pneumoniae - drug effects Klebsiella pneumoniae - genetics Klebsiella pneumoniae - pathogenicity Lipopolysaccharides - biosynthesis Lipopolysaccharides - genetics Models, Genetic Molecular biology Multidrug resistance Natural history Phages Phylogenetics Plasmids Plasmids - genetics Pneumonia Polysaccharides Public health Recombination Virulence Virulence (Microbiology) Virulence - genetics
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