A missense variant in FTCD is associated with arsenic metabolism and toxicity phenotypes in Bangladesh

Inorganic arsenic (iAs) is a carcinogen, and exposure to iAs via food and water is a global public health problem. iAs-contaminated drinking water alone affects >100 million people worldwide, including ~50 million in Bangladesh. Once absorbed into the blood stream, most iAs is converted to mono-m...

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Veröffentlicht in:	PLoS genetics 2019-03, Vol.15 (3), p.e1007984
Hauptverfasser:	Pierce, Brandon L, Tong, Lin, Dean, Samantha, Argos, Maria, Jasmine, Farzana, Rakibuz-Zaman, Muhammad, Sarwar, Golam, Islam, Md Tariqul, Shahriar, Hasan, Islam, Tariqul, Rahman, Mahfuzar, Yunus, Md, Lynch, Vincent J, Oglesbee, Devin, Graziano, Joseph H, Kibriya, Muhammad G, Gamble, Mary V, Ahsan, Habibul
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Alleles Amino acids Ammonia-Lyases - genetics Ammonia-Lyases - physiology Arsenic Arsenic - metabolism Arsenic - toxicity Arsenic compounds Arsenic Poisoning Arsenite Arsenite methyltransferase Bangladesh Biology and Life Sciences Cancer Carbon Carbon cycle Carcinogens Cardiovascular disease Codons Diabetes Drinking behavior Drinking water Efficiency Environmental Exposure Environmental health Enzymes Epidemiology Excretion Female Folic acid Folic Acid - metabolism Funding Gene frequency Gene Frequency - genetics Genetic aspects Genetic diversity Genetic variation Genetics Genomes Glutamate Formimidoyltransferase - genetics Glutamate Formimidoyltransferase - physiology Health sciences Histidine Humans Linkage disequilibrium Longitudinal studies Male Medicine and Health Sciences Metabolism Metabolites Methylation Methyltransferases - genetics Methyltransferases - metabolism Multifunctional Enzymes Mutation, Missense Odds Ratio Phenotype Phenotypes Physical Sciences Physiological aspects Polymorphism, Single Nucleotide - genetics Population studies Protein turnover Public health Risk Factors Single-nucleotide polymorphism Skin Skin diseases Skin Diseases - chemically induced Skin Diseases - genetics Toxicity Transferases Urine Valine Vitamin B Water Water Pollutants, Chemical
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