Plasma membrane architecture protects Candida albicans from killing by copper

The ability to resist copper toxicity is important for microbial pathogens to survive attack by innate immune cells. A sur7Δ mutant of the fungal pathogen Candida albicans exhibits decreased virulence that correlates with increased sensitivity to copper, as well as defects in other stress responses...

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Veröffentlicht in:	PLoS genetics 2019-01, Vol.15 (1), p.e1007911
Hauptverfasser:	Douglas, Lois M, Konopka, James B
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Antimicrobial agents Biology and Life Sciences Blood lipids Brain Candida Candida albicans Candida albicans - drug effects Candida albicans - genetics Candida albicans - pathogenicity Candidiasis - drug therapy Candidiasis - genetics Candidiasis - microbiology CDPdiacylglycerol-Serine O-Phosphatidyltransferase - genetics Cell Membrane Cell membranes Cell Wall - drug effects Cell Wall - genetics Copper Copper (Metal) Copper - chemistry Copper - therapeutic use Cortex Defects Endocytosis - drug effects Genetic screening Genetic testing Humans Hyphae - drug effects Hyphae - genetics Hyphae - pathogenicity Hypothesis testing Immune system Immunity, Innate - drug effects Immunity, Innate - genetics Infections Lipids Localization Medicine and Health Sciences Membrane lipids Membrane Proteins - genetics Membrane trafficking Membranes Metallothionein Metallothionein - genetics Microbial drug resistance Morphogenesis Morphogenesis - drug effects Morphogenesis - genetics Muscle proteins Pathogenic microorganisms Pathogens Peptides Phosphatidylethanolamine Phosphatidylserine Phospholipids Physical Sciences Physiological aspects Plant lipids Plasma Plasma membranes Proteins Research and Analysis Methods Toxicity Transcription factors Virulence Virulence (Microbiology) Yeast
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