R-loops modulate Trypanosome antigenic variation

Diversity generation systems employed by microbes are usually termed antigenic variation systems, and while there are many mechanisms used to promote the expression of various different forms of a gene product, many organisms have co-opted DNA recombination and repair factors to mediate specialized...

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Veröffentlicht in:	PLoS genetics 2018-12, Vol.14 (12), p.e1007809-e1007809
Hauptverfasser:	Prister, Lauren L, Seifert, H Steven
Format:	Artikel
Sprache:	eng
Schlagworte:	African trypanosomiasis Amyotrophic lateral sclerosis Antigenic Variation Antigens, Surface Biodiversity Biology and Life Sciences Deoxyribonucleic acid DNA DNA damage DNA repair DNA-directed RNA polymerase Enzymes Gene conversion Genes Genetic aspects Genetic variation Genomes Glycoproteins Immune Evasion Immunoglobulins Immunology Medicine and Health Sciences Mutation R-loops Recombination Research and analysis methods Ribonuclease H RNA polymerase Transcription activation Trypanosoma Trypanosoma - immunology Trypanosoma brucei Variant surface glycoprotein Variant Surface Glycoproteins, Trypanosoma - genetics Variation
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