BRCA1-BARD1 associate with the synaptonemal complex and pro-crossover factors and influence RAD-51 dynamics during Caenorhabditis elegans meiosis

During meiosis, the maternal and paternal homologous chromosomes must align along their entire length and recombine to achieve faithful segregation in the gametes. Meiotic recombination is accomplished through the formation of DNA double-strand breaks, a subset of which can mature into crossovers to...

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Veröffentlicht in:	PLoS genetics 2018-11, Vol.14 (11), p.e1007653-e1007653
Hauptverfasser:	Janisiw, Eva, Dello Stritto, Maria Rosaria, Jantsch, Verena, Silva, Nicola
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Biology Biology and Life Sciences BRCA1 protein BRCA1 Protein - genetics BRCA1 Protein - metabolism Breast Breast cancer Caenorhabditis elegans Caenorhabditis elegans - genetics Caenorhabditis elegans - metabolism Caenorhabditis elegans Proteins - genetics Caenorhabditis elegans Proteins - metabolism Cell division Chromosome Pairing Chromosomes Crossing over (Genetics) Deoxyribonucleic acid Disease susceptibility DNA DNA damage DNA repair Double-strand break repair Gametes Gametogenesis Genetic aspects Genetics Genomes Germ Cells - metabolism Ionizing radiation Laboratories Localization Medicine and Health Sciences Meiosis Meiosis - genetics Melanocyte stimulating hormone Multiprotein Complexes - metabolism Nematodes Observations Ovarian cancer Parenting Perutz, Max Physiological aspects Prophase Protein Binding Protein Transport Proteins Rad51 Recombinase - genetics Rad51 Recombinase - metabolism Recombinase Recombination Research and Analysis Methods Synaptonemal complex Synaptonemal Complex - metabolism Worms
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