Ancestral origin of ApoE ε4 Alzheimer disease risk in Puerto Rican and African American populations

The ApoE ε4 allele is the most significant genetic risk factor for late-onset Alzheimer disease. The risk conferred by ε4, however, differs across populations, with populations of African ancestry showing lower ε4 risk compared to those of European or Asian ancestry. The cause of this heterogeneity...

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Veröffentlicht in:	PLoS genetics 2018-12, Vol.14 (12), p.e1007791
Hauptverfasser:	Rajabli, Farid, Feliciano, Briseida E, Celis, Katrina, Hamilton-Nelson, Kara L, Whitehead, Patrice L, Adams, Larry D, Bussies, Parker L, Manrique, Clara P, Rodriguez, Alejandra, Rodriguez, Vanessa, Starks, Takiyah, Byfield, Grace E, Sierra Lopez, Carolina B, McCauley, Jacob L, Acosta, Heriberto, Chinea, Angel, Kunkle, Brian W, Reitz, Christiane, Farrer, Lindsay A, Schellenberg, Gerard D, Vardarajan, Badri N, Vance, Jeffery M, Cuccaro, Michael L, Martin, Eden R, Haines, Jonathan L, Byrd, Goldie S, Beecham, Gary W, Pericak-Vance, Margaret A
Format:	Artikel
Sprache:	eng
Schlagworte:	African Americans Aged Aged, 80 and over Aging Alleles Alzheimer Disease - genetics Alzheimer's disease Apolipoprotein E Apolipoprotein E4 - genetics Apolipoproteins Biology and Life Sciences Black or African American - genetics Case-Control Studies Consortia Departments Environmental factors Epidemiology Female Funding Gene Frequency Generalized linear models Genetic diversity Genetic factors Genetic Variation Genetics Genetics, Population Genome-Wide Association Study Genomes Genomics Genotypes Hispanic or Latino - genetics Humans Male Medicine Medicine and Health Sciences Neurodegenerative diseases Neurology People and places Population genetics Principal components analysis Psychiatry Puerto Rico - ethnology Risk Factors Surgeons
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